Article
Psychology, Clinical
Jutta Joormann, Samuel A. McLean, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, Paul Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Gregory Fermann, Lauren A. Hudak, Kamran Mohiuddin, Vishnu Murty, Meghan E. McGrath, John P. Haran, Jose Pascual, Mark Seamon, David A. Peak, Claire Pearson, Robert M. Domeier, Paulina Sergot, Roland Merchant, Leon D. Sanchez, Niels K. Rathlev, William F. Peacock, Steven E. Bruce, Deanna Barch, Diego A. Pizzagalli, Beatriz Luna, Steven E. Harte, Irving Hwang, Sue Lee, Nancy Sampson, Karestan C. Koenen, Kerry J. Ressler, Ronald C. Kessler
Summary: This is the first report on the association between trauma exposure and depression. The study found that the characteristics of motor vehicle collision (MVC) and peritraumatic symptoms are associated with 8-week depression, while peritraumatic symptoms are associated with 2-week depression. The findings suggest the possibility of diverse and complex underlying biological and psychological processes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Cassidy A. Gutner, Jiyoung Song, Caroline A. Canale, Michael K. Suvak, Scott D. Litwack, Barbara L. Niles, Shannon Wiltsey Stirman
Summary: This study compared the effectiveness of UP, PCT, and TAU in trauma-exposed veterans, finding that UP had promising advantages in reducing the number of comorbid diagnoses and significant decreases in self-reported anxiety and depression.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Anton Kurapov, Argyroula Kalaitzaki, Vladyslava Keller, Ivan Danyliuk, Tobias Kowatsch
Summary: This study aimed to investigate the impact of the ongoing war in Ukraine on the mental health of Ukrainians, focusing on war-induced trauma, disturbances in self-organization, post-traumatic stress disorder (PTSD), complex post-traumatic stress disorder (CPTSD), anxiety, stress, and depression. Data was collected from 703 participants 6 months after the full-scale invasion using a structured questionnaire. The study found that levels of depression and anxiety were relatively low, while stress and resilience were relatively high among Ukrainians affected by the war. However, those directly exposed to military actions, violence, or severe suffering had higher levels of anxiety, depression, stress, and trauma-related symptoms. The war experience varied by gender, age, and living conditions. Participants who stayed in Ukraine had significantly lower anxiety, depression, stress, and trauma-related symptoms compared to those who moved abroad. Anxiety, depression, stress, low resilience, and subjective satisfaction with living conditions were predictors of trauma-related symptoms, including PTSD and CPTSD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Clinical
Peter G. van der Velden, Carlo Contino, Ruud Muffels, Mara S. Verheijen, Marcel Das
Summary: Potentially traumatic events are associated with a higher risk of mental health problems and lack of emotional support. The impact of pre-and/or post-trauma financial problems on this risk is largely unknown. This study found that victims of traumatic events with persistent financial problems were more likely to experience anxiety, depression, and lack of emotional support, and were at a higher risk of probable PTSD. It suggests that victim services and healthcare professionals should screen for financial problems and provide appropriate support to aid recovery.
JOURNAL OF ANXIETY DISORDERS
(2023)
Article
Psychology, Clinical
Martin Robinson, Emily McGlinchey, George A. Bonanno, Eric Spikol, Cherie Armour
Summary: This study supports the proposed theory of resilience, the flexibility sequence, based on analysis of survey data from trauma-exposed individuals in the UK. It suggests that this pathway performs better in promoting resilience compared to using these skills/processes in isolation. Further research on the complex associations and feedback loops associated with this pathway is warranted.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychology, Clinical
Sonya B. Norman, Christy Capone, Kaitlyn E. Panza, Moira Haller, Brittany C. Davis, Paula P. Schnurr, M. Tracie Shea, Kendall Browne, Gregory J. Norman, Ariel J. Lang, Alexander C. Kline, Shahrokh Golshan, Carolyn B. Allard, Abigail Angkaw
Summary: This study compared the efficacy of two psychotherapies, TrIGR and SCT, for reducing trauma-related guilt. The results showed that TrIGR was more effective in reducing guilt, PTSD symptoms, and depressive symptoms compared to supportive therapy. TrIGR also had a higher likelihood of treatment response for PTSD and meaningful change in depression.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Charlotte Sonne, Erik Lykke Mortensen, Derrick Silove, Sabina Palic, Jessica Carlsson
Summary: The study found that the severity of initial symptoms and level of functioning in refugees are associated with treatment outcomes. Factors such as short time in host country, full-time occupation, young age, and family reunification status also influence symptom improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Yu Jin, Shicun Xu, Zhishan Hu, Jiaqi Li, Hui Li, Xiaofeng Wang, Xi Sun, Yuanyuan Wang
Summary: This study investigated the different effects of three forms of childhood trauma (emotional abuse, physical abuse, and sexual abuse) on potential psychopathological symptoms among college students. The findings showed that specific symptoms were disclosed across each trauma subgroup, which could aid in the classification and early intervention of mental disorders, ultimately promoting the psychological well-being of trauma survivors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Joseph Maffly-Kipp, Nikolett Eisenbeck, David F. Carreno, Joshua Hicks
Summary: This study found that mental health disparities are greater in countries with more severe COVID-19 outbreaks, with subjective SES, gender, and age as contributing factors. These findings are crucial for understanding the global impact of the ongoing pandemic and its implications for collective trauma.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Nursing
Emma Williamson, Anne Pipeva, Ali Brodrick, Adam Saradjian, Pauline Slade
Summary: The study evaluated the effectiveness of a Birth Trauma psychology clinic integrated into maternity services, with data showing significant reductions in symptoms of PTSD, anxiety, and negative mood among 114 postnatal women. The results suggest that the integrated clinic model is highly efficient and effective for women experiencing symptoms of PTSD following childbirth.
Article
Psychology, Clinical
K. S. Young, K. L. Purves, C. Hubel, M. R. Davies, K. N. Thompson, S. Bristow, G. Krebs, A. Danese, C. Hirsch, C. E. Parsons, E. Vassos, B. N. Adey, S. Bright, L. Hegemann, Y. T. Lee, G. Kalsi, D. Monssen, J. Mundy, A. J. Peel, C. Rayner, H. C. Rogers, A. Ter Kuile, C. Ward, K. York, Y. Lin, A. B. Palmos, U. Schmidt, D. Veale, T. R. Nicholson, T. A. Pollak, S. A. M. Stevelink, T. Moukhtarian, A. R. Martineau, H. Holt, B. Maughan, A. Al-Chalabi, K. Ray Chaudhuri, M. P. Richardson, J. R. Bradley, P. F. Chinnery, N. Kingston, S. Papadia, K. E. Stirrups, R. Linger, M. Hotopf, T. C. Eley, G. Breen
Summary: This study examines the impact of the COVID-19 pandemic on mental health and identifies key risk factors for worsening symptoms. The results show small decreases in depression and anxiety symptoms and increases in PTSD symptoms in prospective analyses. However, retrospective analyses demonstrate significant large increases in depression and anxiety symptoms, with 55% of participants reporting worsening mental health since the beginning of the pandemic. Worsening symptoms are associated with prior mental health diagnoses, female gender, young age, and unemployed/student status.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Siti Raudzah Ghazali, Yoke Yong Chen, Mardiana Mohamad, Lee Ping Yein, Zul Azlin Razali, Noraskin Pauzi, Alia Fadaliana Majani
Summary: This study provides significant understanding of the link between PTSD, depressive symptoms, and suicidal behavior among Malaysian university students. The results of the survey showed that at least 87% of the students had experienced lifetime trauma, 9.6% exhibited symptoms of PTSD, 15.5% exhibited depressive symptoms, and 12.9% reported having suicidal behavior.
CURRENT PSYCHOLOGY
(2023)
Review
Medicine, General & Internal
Lauren P. Wadsworth, Inga Wessman, Andri Steinpor Bjornsson, Gudbjorg Jonsdottir, Sigurdur Yngvi Kristinsson
Summary: The mental health effects of cancer screening are uncertain, with conflicting literature indicating negative, neutral, and positive impacts. More randomized controlled trials are needed to study the mental health effects of cancer screening. The greater the negativity and life-threatening potential of the screening results, the stronger the mental health effects.
Article
Clinical Neurology
Chengqi Cao, Li Wang, Ruojiao Fang, Ping Liu, Yajie Bi, Shu Luo, Emma Grace, Miranda Olff
Summary: This study found that the prevalence of anxiety, depression, and PTSD symptoms was relatively high among adolescents in China, with family relationships and social support being the most important predictors for mental health outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Suzan Soydas, Geert E. Smid, Lonneke I. M. Lenferink, A. A. Manik J. Djelantik, Barbara Goodfellow, Rachel Wilson, Paul A. Boelen
Summary: The study identified three subgroups among violently bereaved individuals based on levels of distress and depression symptoms. Females and individuals with prior life stress experiences were distinguishing factors between these subgroups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Nathaniel G. Harnett, Jennifer S. Stevens, Negar Fani, Sanne J. H. van Rooij, Timothy D. Ely, Vasiliki Michopoulos, Lauren Hudak, Alex O. Rothbaum, Rebecca Hinrichs, Sterling J. Winters, Tanja Jovanovic, Barbara O. Rothbaum, Lisa D. Nickerson, Kerry J. Ressler
Summary: This study investigated the relationship between structural covariance networks (SCNs) and acute posttraumatic stress severity using multimodal magnetic resonance imaging. The results revealed a specific SCN pattern that was related to acute posttraumatic stress severity and changes in PTSD symptom severity over time. These findings provide insights into the neural mechanisms of acute posttraumatic stress and could potentially serve as neural markers for susceptibility to PTSD development.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Review
Clinical Neurology
Kerry J. Ressler, Sabina Berretta, Vadim Y. Bolshakov, Isabelle M. Rosso, Edward G. Meloni, Scott L. Rauch, William A. Carlezon
Summary: Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by maladaptive symptoms following exposure to severe trauma. The neurobiology of PTSD, including genetic factors and dysregulation of fear processes, has been extensively studied. Combining molecular-genetic approaches with a translational understanding of fear circuitry could lead to transformative advances in the diagnosis and treatment of PTSD.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Psychology, Clinical
Scott W. Delaney, Yllza Xerxa, Ryan L. Muetzel, Tonya White, Sebastien Haneuse, Kerry J. Ressler, Henning Tiemeier, Laura D. Kubzansky
Summary: The study suggests that positive prenatal family environments may have lasting benefits on white matter neurodevelopment in preadolescence, which can reduce the risk of behavior problems.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Abigail Powers, Cecilia A. Hinojosa, Jennifer S. Stevens, Brandon Harvey, Pascal Pas, Barbara O. Rothbaum, Kerry J. Ressler, Tanja Jovanovic, Sanne J. H. van Rooij
Summary: This study used functional magnetic resonance imaging (fMRI) to examine the predictive role of impaired reactive and proactive inhibition on the development of PTSD symptoms after acute trauma. The findings suggest that reduced activation in the right inferior frontal gyrus (rIFG) and ventromedial prefrontal cortex (vmPFC) during response inhibition may predict the development of PTSD symptoms six months after trauma exposure.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychiatry
Lauren A. M. Lebois, Nathaniel G. Harnett, Sanne J. H. van Rooij, Timothy D. Ely, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Caitlin Ravichandran, Nathalie M. Dumornay, Katherine E. Finegold, Sarah B. Hill, Julia B. Merker, Karlye A. Phillips, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Robert A. Swor, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Anna M. Chang, Claire Pearson, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Beatriz Luna, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Jennifer S. Stevens, Kerry J. Ressler
Summary: The study found that persistent dissociation after trauma can predict worse psychiatric outcomes, and the neural correlates of trauma-related dissociation may be potential targets for treatment engagement to prevent posttraumatic stress disorder.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Busra Tanriverdi, David F. Gregory, Thomas M. Olino, Timothy D. Ely, Nathaniel G. Harnett, Sanne J. H. van Rooij, Lauren A. M. Lebois, Antonia Seligowski, Tanja Jovanovic, Kerry J. Ressler, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Steven E. Harte, James M. Elliott, Samuel A. McLean, Ronald C. Kessler, Karestan C. Koenen, Jennifer S. Stevens, Vishnu P. Murty
Summary: Hippocampal impairments are associated with post-traumatic stress disorder (PTSD), particularly in individuals with increased threat sensitivity and arousal responses. This study found that individuals who showed high threat-related arousal had decreased hippocampal responses to threat, which were associated with PTSD symptoms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Evelina Sterina, Vasiliki Michopoulos, Sarah D. Linnstaedt, Thomas C. Neylan, Gari D. Clifford, Kelly F. Ethun, Adriana Lori, Aliza P. Wingo, Barbara O. Rothbaum, Kerry J. Ressler, Jennifer S. Stevens
Summary: This study found a negative correlation between the time of trauma and PTSD symptoms. Cortisol levels were not correlated with blood draw time, possibly due to the acute stress response masking the underlying circadian rhythm. There were also interactions between trauma time and the expression of certain genes that predicted PTSD symptoms.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychiatry
Nathaniel G. Harnett, Katherine E. Finegold, Lauren A. M. Lebois, Sanne J. H. van Rooij, Timothy D. Ely, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Lisa D. Nickerson, Kerry J. Ressler, Jennifer S. Stevens
Summary: The structural integrity of the ventral visual stream plays a significant role in the development of PTSD symptoms. The visual circuitry related to trauma memories may contribute to the re-experiencing of traumatic events and worsen PTSD symptoms over time. Evaluating the connectivity and activity within these networks can provide a better understanding of the underlying mechanisms of PTSD.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Siddhartha Kosaraju, Isaac Galatzer-Levy, Katharina Schultebraucks, Sterling Winters, Rebecca Hinrichs, Preethi J. Reddi, Jessica L. Maples-Keller, Lauren Hudak, Vasiliki Michopoulos, Tanja Jovanovic, Kerry J. Ressler, Jason W. Allen, Jennifer S. Stevens
Summary: This study examines the correlation between posttraumatic stress disorder (PTSD), mild traumatic brain injury (mTBI), and structural brain alterations. The results show a positive correlation between mTBI with loss of consciousness (LOC) during trauma and the likelihood of developing chronic PTSD symptoms. Furthermore, the interaction between mTBI with LOC and cortical thickness in the rostral anterior cingulate cortex (rACC) predicts subsequent chronic PTSD symptoms. These findings highlight the importance of understanding the role of mTBI in the context of PTSD for intervention and risk stratification.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Clinical Neurology
Grace E. Rowland, Yara Mekawi, Vasiliki Michopoulos, Abigail Powers, Negar Fani, Bekh Bradley, Kerry J. Ressler, Tanja Jovanovic, Jennifer S. Stevens
Summary: The study found that exposure to sexual trauma is associated with more severe PTSD symptoms, regardless of the developmental timing. However, survivors of sexual trauma do not have distinct symptom profiles compared to survivors of non-sexual trauma.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Adam X. Maihofer, Worrawat Engchuan, Guillaume Huguet, Marieke Klein, Jeffrey R. MacDonald, Omar Shanta, Bhooma Thiruvahindrapuram, Martineau Jean-louis, Zohra Saci, Sebastien Jacquemont, Stephen W. Scherer, Elizabeth Ketema, Allison E. Aiello, Ananda B. Amstadter, Esmina Avdibegovic, Dragan Babic, Dewleen G. Baker, Jonathan Bisson, Marco P. Boks, Elizabeth A. Bolger, Richard A. Bryant, Angela C. Bustamante, Jose Miguel Caldas-de-Almeida, Graca Cardoso, Jurgen Deckert, Douglas L. Delahanty, Katharina Domschke, Boadie W. Dunlop, Alma Dzubur-Kulenovic, Alexandra Evans, Norah C. Feeny, Carol E. Franz, Aarti Gautam, Elbert Geuze, Aferdita Goci, Rasha Hammamieh, Miro Jakovljevic, Marti Jett, Ian Jones, Milissa L. Kaufman, Ronald C. Kessler, Anthony P. King, William S. Kremen, Bruce R. Lawford, Lauren A. M. Lebois, Catrin Lewis, Israel Liberzon, Sarah D. Linnstaedt, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Matig R. Mavissakalian, Katie A. McLaughlin, Samuel A. McLean, Divya Mehta, Rebecca Mellor, Charles Phillip Morris, Seid Muhie, Holly K. Orcutt, Matthew Peverill, Andrew Ratanatharathorn, Victoria B. Risbrough, Albert Rizzo, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Kenneth J. Ruggiero, Bart P. F. Rutten, Dick Schijven, Julia S. Seng, Christina M. Sheerin, Michael A. Sorenson, Martin H. Teicher, Monica Uddin, Robert J. Ursano, Christiaan H. Vinkers, Joanne Voisey, Heike Weber, Sherry Winternitz, Miguel Xavier, Ruoting Yang, Ross McD Young, Lori A. Zoellner, Rany M. Salem, Richard A. Shaffer, Tianying Wu, Kerry J. Ressler, Murray B. Stein, Karestan C. Koenen, Jonathan Sebat, Caroline M. Nievergelt
Summary: This study investigates the association between copy number variation (CNV) and posttraumatic stress disorder (PTSD) symptoms. The findings suggest that neurodevelopmental CNV burden is related to the variation in PTSD symptoms. Furthermore, specific gene sets related to the function of the nervous system and brain show significant association with PTSD. However, no individual significant genes interrupted by CNV were identified, and the associations with gene pathways were no longer significant once neurodevelopmental disorder regions were removed. Further research with larger sample sizes and improved detection methods is needed to explore this relationship further.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Negar Fani, Leyla Eghbalzad, Nathaniel G. Harnett, Sierra E. Carter, Matthew Price, Jennifer S. Stevens, Kerry J. Ressler, Sanne J. H. van Rooij, Bekh Bradley
Summary: Racial discrimination is consistently associated with adverse brain health outcomes in Black women, specifically decreased gray matter thickness in the cingulate cortex.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Erin Hisey, Alicia Purkey, Yudong Gao, Kazi Hossain, Scott H. Soderling, Kerry J. Ressler
Summary: This study reveals the crucial role of the prefrontal cortex (PFC) and hippocampus in threat memory processing, particularly in modulating the gain of behavioral output during threat retrieval and encoding. The projection from the ventromedial PFC to the lateral entorhinal cortex (LEC) is found to be involved in this modulation. This finding provides potential targets for intervention in threat-related disorders.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Samantha A. Wong, Lauren A. M. Lebois, Timothy D. Ely, Sanne J. H. van Rooij, Steven E. Bruce, Vishnu P. Murty, Tanja Jovanovic, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey Jr, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Kerry J. Ressler, Jennifer S. Stevens, Nathaniel G. Harnett
Summary: Childhood trauma has a significant impact on white matter microstructure and future posttraumatic dysfunction. The internal capsule (IC) microstructure plays a crucial role in connecting childhood trauma with PTSD symptoms, while other white matter tracts do not show such mediation. This study highlights the importance of IC as a stable neural pathway between childhood trauma and PTSD symptoms.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Erin E. Hisey, Emma L. Fritsch, Emily L. Newman, Kerry J. Ressler, Brian D. Kangas, William A. A. Carlezon Jr
Summary: Early-life stress has long-lasting impacts on the brain, increasing the risk of psychiatric illnesses. By modeling human early-life stress in mice, researchers have identified biomarkers that are relevant to mood and anxiety disorders, which can potentially improve treatment and prevention strategies.
NEUROPSYCHOPHARMACOLOGY
(2023)
