Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex
Authors
Keywords
-
Journal
Frontiers in Endocrinology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-12-14
DOI
10.3389/fendo.2017.00351
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
- (2017) Karen Cerosaletti et al. JOURNAL OF IMMUNOLOGY
- Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells
- (2017) Thomas Lee et al. JOURNAL OF IMMUNOLOGY
- CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage
- (2017) Yannick F. Fuchs et al. Scientific Reports
- Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
- (2016) Aaron W. Michels et al. DIABETES
- Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes
- (2016) Meghan L. Marré et al. JOURNAL OF AUTOIMMUNITY
- Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
- (2016) David K. Cole et al. JOURNAL OF CLINICAL INVESTIGATION
- Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice
- (2016) Ningwen Tai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rapid identification and expression of human TCRs in retrogenic mice
- (2016) Maran L. Sprouse et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
- (2016) Jenny Aurielle B Babon et al. NATURE MEDICINE
- Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
- (2016) T. Delong et al. SCIENCE
- Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
- (2016) Jiqiang Lin et al. Nature Communications
- Low-affinity CD4+ T cells are major responders in the primary immune response
- (2016) Ryan J. Martinez et al. Nature Communications
- Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
- (2016) Thomas Lee et al. Jove-Journal of Visualized Experiments
- Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance
- (2015) Hiroyuki Takaba et al. CELL
- The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes
- (2015) Aleksandar D. Kostic et al. Cell Host & Microbe
- Immunoproteomic Profiling of Anti-Viral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
- (2015) Xiaofang Bian et al. DIABETES
- T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity
- (2015) Ryan W. Nelson et al. IMMUNITY
- A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes
- (2015) Tiffany C. Scharschmidt et al. IMMUNITY
- Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes
- (2015) Wong Yu et al. IMMUNITY
- Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes
- (2015) Rocky L. Baker et al. JOURNAL OF IMMUNOLOGY
- High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4+T Cells
- (2015) Anne Eugster et al. JOURNAL OF IMMUNOLOGY
- Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
- (2015) S. Yang et al. SCIENCE
- Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes
- (2014) Vimukthi Pathiraja et al. DIABETES
- Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
- (2014) J. W. McGinty et al. DIABETES
- TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential
- (2014) Maria Bettini et al. JOURNAL OF IMMUNOLOGY
- The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function
- (2014) Kristin A Hogquist et al. NATURE IMMUNOLOGY
- Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC
- (2014) Stephen P Persaud et al. NATURE IMMUNOLOGY
- Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
- (2014) Y. Ito et al. SCIENCE
- Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
- (2013) M. van Lummel et al. DIABETES
- Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression
- (2013) M. Galgani et al. DIABETES
- T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens
- (2013) Judith N. Mandl et al. IMMUNITY
- Gender Bias in Autoimmunity Is Influenced by Microbiota
- (2013) Leonid Yurkovetskiy et al. IMMUNITY
- Chromogranin A is a T cell antigen in human type 1 diabetes
- (2013) Peter A. Gottlieb et al. JOURNAL OF AUTOIMMUNITY
- Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes
- (2013) James F. Mohan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner
- (2013) Q. He et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice
- (2013) R. L. Baker et al. JOURNAL OF IMMUNOLOGY
- Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
- (2013) J. G. M. Markle et al. SCIENCE
- Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease
- (2013) Oskar Skog et al. Current Opinion in Endocrinology Diabetes and Obesity
- MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity
- (2013) Sue Tsai et al. Frontiers in Immunology
- Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
- (2012) G. M. Alkemade et al. DIABETES
- Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
- (2012) T. Delong et al. DIABETES
- Fecal Microbiota Composition Differs Between Children With -Cell Autoimmunity and Those Without
- (2012) M. C. de Goffau et al. DIABETES
- T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice
- (2012) Matthew L. Bettini et al. IMMUNOLOGY
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
- (2012) Ken T. Coppieters et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Self-reactive human CD4 T cell clones form unusual immunological synapses
- (2012) David A. Schubert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics
- (2012) Kristen M. Rosenthal et al. PLoS One
- Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice
- (2012) Wendy W. J. Unger et al. PLoS One
- T cell-driven initiation and propagation of autoimmune diabetes
- (2011) Maria Bettini et al. CURRENT OPINION IN IMMUNOLOGY
- CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes
- (2011) Kathryn Haskins et al. CURRENT OPINION IN IMMUNOLOGY
- Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk
- (2011) E. Bonifacio et al. DIABETES
- A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
- (2011) Linda Wooldridge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC
- (2011) Dhruv K. Sethi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses
- (2011) Joseph J. Sabatino et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
- (2011) James F. Mohan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
- (2011) Tom L. Van Belle et al. PHYSIOLOGICAL REVIEWS
- Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
- (2011) B. Calderon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
- (2011) F. Crawford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulitis in human type 1 diabetes
- (2011) Peter In't Veld Islets
- Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes
- (2010) Terri C. Thayer et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin
- (2010) I Durinovic-Belló et al. GENES AND IMMUNITY
- Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?
- (2010) Xunrong Luo et al. IMMUNITY
- Prediction and Pathogenesis in Type 1 Diabetes
- (2010) Anette-G. Ziegler et al. IMMUNITY
- T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes
- (2010) Jeffrey Babad et al. IMMUNOLOGY
- Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
- (2010) James F Mohan et al. NATURE IMMUNOLOGY
- In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation
- (2010) J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
- (2010) B. D. Stadinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
- (2010) John P. Driver et al. Seminars in Immunopathology
- AIRE in the thymus and beyond
- (2009) James M Gardner et al. CURRENT OPINION IN IMMUNOLOGY
- Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes
- (2009) F. S. Wong et al. DIABETES
- Thymus-specific deletion of insulin induces autoimmune diabetes
- (2009) Yong Fan et al. EMBO JOURNAL
- T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous Event
- (2009) Greig P. Lennon et al. IMMUNITY
- Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8.NODAbo transgenic mice
- (2009) Veena Taneja et al. JOURNAL OF AUTOIMMUNITY
- TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes
- (2009) Monica W.L. Leung et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genetics of Type 1A Diabetes
- (2009) Patrick Concannon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glutamic Acid Decarboxylase-Derived Epitopes with Specific Domains Expand CD4+CD25+ Regulatory T Cells
- (2009) Guojiang Chen et al. PLoS One
- Analysis of islet inflammation in human type 1 diabetes
- (2008) A. Willcox et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes
- (2008) J. M. Wenzlau et al. DIABETES
- On the Pathogenicity of Autoantigen-Specific T-Cell Receptors
- (2008) A. R. Burton et al. DIABETES
- HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families
- (2008) H. Erlich et al. DIABETES
- Primer: Immunity and Autoimmunity
- (2008) M. Pietropaolo et al. DIABETES
- CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
- (2008) Ania Skowera et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells
- (2008) Rodolfo José Chaparro et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Conserved T cell receptor -chain induces insulin autoantibodies
- (2008) M. Kobayashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice
- (2008) F. Menconi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice
- (2007) John A. Gebe et al. JOURNAL OF AUTOIMMUNITY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now