Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

Retrogenic Modeling of Experimental Allergic Encephalomyelitis Associates T Cell Frequency but Not TCR Functional Affinity with Pathogenicity

(2014) R. Alli et al.   JOURNAL OF IMMUNOLOGY

Induction of Anergy by Antibody Blockade of TCR in Myelin Oligodendrocyte Glycoprotein-Specific Cells

(2014) H. A. Wasserman et al.   JOURNAL OF IMMUNOLOGY

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1

(2014) H. A. Wasserman et al.   JOURNAL OF IMMUNOLOGY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

(2011) K. Adachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity

(2010) Magali Irla et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2

(2010) J. W. Leavenworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8+ T Cell Responses to a Viral Escape Mutant Epitope: Active Suppression via Altered SHP-1 Activity

(2009) F. J. Schnell et al.   JOURNAL OF IMMUNOLOGY

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

(2009) E. Landais et al.   JOURNAL OF IMMUNOLOGY

Manipulating Antigenic Ligand Strength to Selectively Target Myelin-Reactive CD4+ T Cells in EAE

(2009) Joseph J. Sabatino et al.   Journal of Neuroimmune Pharmacology

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis

(2009) Gurumoorthy Krishnamoorthy et al.   NATURE MEDICINE

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

(2008) Matthew A. Williams et al.   IMMUNITY