Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

(2017) Karen Cerosaletti et al.   JOURNAL OF IMMUNOLOGY

Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells

(2017) Thomas Lee et al.   JOURNAL OF IMMUNOLOGY

CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage

(2017) Yannick F. Fuchs et al.   Scientific Reports

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes

(2016) Meghan L. Marré et al.   JOURNAL OF AUTOIMMUNITY

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

(2016) Ningwen Tai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid identification and expression of human TCRs in retrogenic mice

(2016) Maran L. Sprouse et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

(2016) Jiqiang Lin et al.   Nature Communications

Low-affinity CD4+ T cells are major responders in the primary immune response

(2016) Ryan J. Martinez et al.   Nature Communications

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

(2016) Thomas Lee et al.   Jove-Journal of Visualized Experiments

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance

(2015) Hiroyuki Takaba et al.   CELL

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Immunoproteomic Profiling of Anti-Viral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays

(2015) Xiaofang Bian et al.   DIABETES

T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

(2015) Ryan W. Nelson et al.   IMMUNITY

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes

(2015) Rocky L. Baker et al.   JOURNAL OF IMMUNOLOGY

High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4+T Cells

(2015) Anne Eugster et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

(2014) Vimukthi Pathiraja et al.   DIABETES

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

(2014) J. W. McGinty et al.   DIABETES

TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential

(2014) Maria Bettini et al.   JOURNAL OF IMMUNOLOGY

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

(2014) Kristin A Hogquist et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

(2014) Y. Ito et al.   SCIENCE

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

(2013) M. van Lummel et al.   DIABETES

Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

(2013) M. Galgani et al.   DIABETES

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

Chromogranin A is a T cell antigen in human type 1 diabetes

(2013) Peter A. Gottlieb et al.   JOURNAL OF AUTOIMMUNITY

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner

(2013) Q. He et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice

(2013) R. L. Baker et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease

(2013) Oskar Skog et al.   Current Opinion in Endocrinology Diabetes and Obesity

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity

(2013) Sue Tsai et al.   Frontiers in Immunology

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts

(2012) G. M. Alkemade et al.   DIABETES

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A

(2012) T. Delong et al.   DIABETES

Fecal Microbiota Composition Differs Between Children With  -Cell Autoimmunity and Those Without

(2012) M. C. de Goffau et al.   DIABETES

T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice

(2012) Matthew L. Bettini et al.   IMMUNOLOGY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

(2012) Kristen M. Rosenthal et al.   PLoS One

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

T cell-driven initiation and propagation of autoimmune diabetes

(2011) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes

(2011) Kathryn Haskins et al.   CURRENT OPINION IN IMMUNOLOGY

Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk

(2011) E. Bonifacio et al.   DIABETES

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

(2011) Dhruv K. Sethi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans

(2011) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

(2011) F. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes

(2010) Terri C. Thayer et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

(2010) I Durinovic-Belló et al.   GENES AND IMMUNITY

Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?

(2010) Xunrong Luo et al.   IMMUNITY

Prediction and Pathogenesis in Type 1 Diabetes

(2010) Anette-G. Ziegler et al.   IMMUNITY

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes

(2010) Jeffrey Babad et al.   IMMUNOLOGY

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

(2010) John P. Driver et al.   Seminars in Immunopathology

AIRE in the thymus and beyond

(2009) James M Gardner et al.   CURRENT OPINION IN IMMUNOLOGY

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

(2009) F. S. Wong et al.   DIABETES

Thymus-specific deletion of insulin induces autoimmune diabetes

(2009) Yong Fan et al.   EMBO JOURNAL

T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous Event

(2009) Greig P. Lennon et al.   IMMUNITY

Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8.NODAbo transgenic mice

(2009) Veena Taneja et al.   JOURNAL OF AUTOIMMUNITY

TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes

(2009) Monica W.L. Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glutamic Acid Decarboxylase-Derived Epitopes with Specific Domains Expand CD4+CD25+ Regulatory T Cells

(2009) Guojiang Chen et al.   PLoS One

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

(2008) J. M. Wenzlau et al.   DIABETES

On the Pathogenicity of Autoantigen-Specific T-Cell Receptors

(2008) A. R. Burton et al.   DIABETES

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

Primer: Immunity and Autoimmunity

(2008) M. Pietropaolo et al.   DIABETES

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

(2008) Ania Skowera et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells

(2008) Rodolfo José Chaparro et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Conserved T cell receptor  -chain induces insulin autoantibodies

(2008) M. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice

(2008) F. Menconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice

(2007) John A. Gebe et al.   JOURNAL OF AUTOIMMUNITY