Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

(2015) Tomoyoshi Yamano et al.   IMMUNITY

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

(2015) David M. Richards et al.   JOURNAL OF IMMUNOLOGY

Osteoprotegerin-Mediated Homeostasis of Rank+Thymic Epithelial Cells Does Not Limit Foxp3+Regulatory T Cell Development

(2015) Nicholas I. McCarthy et al.   JOURNAL OF IMMUNOLOGY

Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition

(2015) Brian M Weist et al.   NATURE IMMUNOLOGY

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

Love Is in the Aire: mTECs Share Their Assets

(2014) Bruno Kyewski et al.   IMMUNITY

Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

(2014) Nobuko Akiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymic Emigration: When and How T Cells Leave Home

(2014) M. A. Weinreich et al.   JOURNAL OF IMMUNOLOGY

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

The same self-peptide selects conventional and regulatory CD4+ T cells with identical antigen receptors

(2014) Lukasz Wojciech et al.   Nature Communications

Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance

(2013) Chunyan Wu et al.   Autophagy

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

(2013) Xuguang Tai et al.   IMMUNITY

Medullary thymic epithelial cell depletion leads to autoimmune hepatitis

(2013) Anthony J. Bonito et al.   JOURNAL OF CLINICAL INVESTIGATION

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of APC Types Involved in CD4 Tolerance and Regulatory T Cell Generation Using Reaggregated Thymic Organ Cultures

(2013) L. Guerri et al.   JOURNAL OF IMMUNOLOGY

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

(2012) R. T. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

Control of central and peripheral tolerance by Aire

(2011) Todd C. Metzger et al.   IMMUNOLOGICAL REVIEWS

Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity

(2011) A. Giangreco et al.   JOURNAL OF IMMUNOLOGY

A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease

(2011) J. R. Killebrew et al.   JOURNAL OF IMMUNOLOGY

Diversity of TCRs on Natural Foxp3+ T Cells in Mice Lacking Aire Expression

(2010) D. Daniely et al.   JOURNAL OF IMMUNOLOGY

Functional Redundancy between Thymic CD8 + and Sirp + Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins

(2010) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus

(2010) E. Roman et al.   JOURNAL OF IMMUNOLOGY

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

Aire

(2009) Diane Mathis et al.   Annual Review of Immunology

TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes

(2009) Monica W.L. Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

(2009) JiChu Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial Contribution of Thymic Sirp + Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner

(2009) T. Baba et al.   JOURNAL OF IMMUNOLOGY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg

(2008) Richard J. DiPaolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

(2008) Maria A. Curotto de Lafaille et al.   IMMUNITY

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

Foxp3+regulatory T cells maintain immune homeostasis in the skin

(2008) Jan C. Dudda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

(2008) J. Villasenor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

(2008) J. Derbinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology