4.5 Article

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

Journal

SYNTHESIS-STUTTGART
Volume 46, Issue 9, Pages 1254-1260

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1340840

Keywords

trifluoromethyl group; trifluoroacetyl group; fluorine; pyrazole; building blocks

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Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.

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