Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 8, Pages 1002-1009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op500102h
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- CNRS France
- Bayer S.A.S.
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The synthesis of 3,5-bis(fluoroalkyl)-pyrazoles as novel agrophores is described. Commercially available fluoroacetoacetates are treated with BF3-activated TFEDMA affording in a straightforward one-pot sequence pyrazole carboxylates in good yields and with excellent regioselectivity. The carboxylate intermediates have been converted into the corresponding pyrazolic acids and submitted to decarboxylation, affording valuable building blocks for the design of novel bioactive ingredients. The found process is suitable for scale up and preparation of compounds in kilogram quantity.
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