Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 10, Pages 4105-4111Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2000989
Keywords
-
Categories
Funding
- Research Foundation-Flanders
- Ghent University (GOA, BOF)
- Janssen Research and Development, a Division of Janssen Pharmaceutica NV
Ask authors/readers for more resources
Fluorinated pyrazoles bearing additional functional groups that allow further functionalization are of considerable interest as building blocks in medicinal chemistry. The developed synthetic strategy for new 3-amino-4-fluoropyrazoles consists of a monofluorination of beta-methylthio-beta-enaminoketones using 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor) toward the corresponding monofluorinated enaminoketones, followed by condensation with different hydrazines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available