Journal
GREEN CHEMISTRY
Volume 17, Issue 2, Pages 842-847Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc02028f
Keywords
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Funding
- Ministry of Science and Technological Development of the Republic of Serbia [172016]
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A green, simple and highly efficient method for the synthesis of pyrazole-3-carboxylates and 3,5-disubstituted pyrazoles by cyclization of 4-aryl(hetaryl, alkyl)-2,4-diketoesters and 1,3-diketones with semicarbazide hydrochloride under on water conditions has been developed. This method also does not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.
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