Journal
MOLECULES
Volume 16, Issue 11, Pages 9340-9356Publisher
MDPI
DOI: 10.3390/molecules16119340
Keywords
alkyne; cyclocondensation; multi-component reaction; pyrazole; Sonogashira coupling
Funding
- Fonds der Chemischen Industrie
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A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 degrees C rapidly furnishes the title compounds in a one-pot fashion.
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