Recent lab-on-chip developments for novel drug discovery

Droplets and Bubbles in Microfluidic Devices

(2016) Shelley Lynn Anna   Annual Review of Fluid Mechanics

Screening applications in drug discovery based on microfluidic technology

(2016) P. Eribol et al.   Biomicrofluidics

Recent advances in lab-on-a-chip for biosensing applications

(2016) Josiane P. Lafleur et al.   BIOSENSORS & BIOELECTRONICS

Cell stretching devices as research tools: engineering and biological considerations

(2016) Harshad Kamble et al.   LAB ON A CHIP

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

(2016) Shinuo Weng et al.   NATURE MATERIALS

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Multiscale and Multimaterial Fabrication: The Challenge Ahead

(2016) Nam-Trung Nguyen   Micromachines

A Microchip for High-Throughput Axon Growth Drug Screening

(2016) Hyun Kim et al.   Micromachines

Stacked Integration of MEMS on LSI

(2016) Masayoshi Esashi et al.   Micromachines

Programmable Laser-Assisted Surface Microfabrication on a Poly(Vinyl Alcohol)-Coated Glass Chip with Self-Changing Cell Adhesivity for Heterotypic Cell Patterning

(2015) Yi-Chen Li et al.   ACS Applied Materials & Interfaces

Artefacts at the liquid interface and their impact in miniaturized biochemical assay

(2015) Brett Litten et al.   Biomicrofluidics

Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform

(2015) Christina Cortez-Jugo et al.   Biomicrofluidics

Monodisperse aqueous microspheres encapsulating high concentration ofl-ascorbic acid: insights of preparation and stability evaluation from straight-through microchannel emulsification

(2015) Nauman Khalid et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Successes and future outlook for microfluidics-based cardiovascular drug discovery

(2015) Joanna Skommer et al.   Expert Opinion on Drug Discovery

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Drug delivery into microneedle-porated nails from nanoparticle reservoirs

(2015) Wing Sin Chiu et al.   JOURNAL OF CONTROLLED RELEASE

High-throughput mapping of brain-wide activity in awake and drug-responsive vertebrates

(2015) Xudong Lin et al.   LAB ON A CHIP

Ultrasonic welding for fast bonding of self-aligned structures in lab-on-a-chip systems

(2015) K. Kistrup et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

Microscale technology and biocatalytic processes: opportunities and challenges for synthesis

(2015) Roland Wohlgemuth et al.   TRENDS IN BIOTECHNOLOGY

Formulation characteristics of triacylglycerol oil-in-water emulsions loaded with ergocalciferol using microchannel emulsification

(2015) Nauman Khalid et al.   RSC Advances

Recent developments in multilayered polymeric particles – from fabrication techniques to therapeutic formulations

(2015) Sampa Saha et al.   Journal of Materials Chemistry B

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

(2014) Michael Werner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Integrated Array of Microfluidic Oxygenators as a Neonatal Lung Assist Device: In Vitro Characterization and In Vivo Demonstration

(2014) Niels Rochow et al.   ARTIFICIAL ORGANS

Electrical cell counting process characterization in a microfluidic impedance cytometer

(2014) Umer Hassan et al.   BIOMEDICAL MICRODEVICES

Monodisperse W/O/W emulsions encapsulating l-ascorbic acid: Insights on their formulation using microchannel emulsification and stability studies

(2014) Nauman Khalid et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Therapeutic applications of hydrogels in oral drug delivery

(2014) Lindsey A Sharpe et al.   Expert Opinion on Drug Delivery

Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

(2014) Yue Shao et al.   Integrative Biology

Chemically induced synaptic activity between mixed primary hippocampal co-cultures in a microfluidic system

(2014) Graham Robertson et al.   Integrative Biology

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

(2014) Jacquelyn A Brown et al.   Journal of Neuroinflammation

Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips

(2014) A. Ruiz et al.   LAB ON A CHIP

A functional microengineered model of the human splenon-on-a-chip

(2014) L. G. Rigat-Brugarolas et al.   LAB ON A CHIP

Biomimetic Microfluidic Device for in Vitro Antihypertensive Drug Evaluation

(2014) Lei Li et al.   MOLECULAR PHARMACEUTICS

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

(2014) Cheri Y. Li et al.   TISSUE ENGINEERING PART A

Commercialization of microfluidic devices

(2014) Lisa R. Volpatti et al.   TRENDS IN BIOTECHNOLOGY

Lab-on-a-chip technologies for stem cell analysis

(2014) Peter Ertl et al.   TRENDS IN BIOTECHNOLOGY

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

(2013) Goran T. Vladisavljević et al.   ADVANCED DRUG DELIVERY REVIEWS

Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

(2013) Nam-Trung Nguyen et al.   ADVANCED DRUG DELIVERY REVIEWS

A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition

(2013) Fabrice Gielen et al.   ANALYTICAL CHEMISTRY

3D-printed devices for continuous-flow organic chemistry

(2013) Vincenza Dragone et al.   Beilstein Journal of Organic Chemistry

Parallel generation of uniform fine droplets at hundreds of kilohertz in a flow-focusing module

(2013) David Bardin et al.   Biomicrofluidics

Microfluidic culture models to study the hydrodynamics of tumor progression and therapeutic response

(2013) Cara Buchanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption

(2013) Si Hyeon Kim et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Rapid fabrication of nickel molds for prototyping embossed plastic microfluidic devices

(2013) Richard Novak et al.   LAB ON A CHIP

Engineering microfluidic concentration gradient generators for biological applications

(2013) Alicia G. G. Toh et al.   Microfluidics and Nanofluidics

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

(2013) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors Associated with Multiple FDA Review Cycles and Approval Phase Times

(2012) Joseph A. DiMasi et al.   DRUG INFORMATION JOURNAL

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

(2012) G. T. Vladisavljević et al.   Microfluidics and Nanofluidics

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

(2012) Sang-Hyug Park et al.   PLoS One

First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip

(2012) R. Farra et al.   Science Translational Medicine

Gradient-Regulated Hydrogel for Interface Tissue Engineering: Steering Simultaneous Osteo/Chondrogenesis of Stem Cells on a Chip

(2012) Xuetao Shi et al.   Advanced Healthcare Materials

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

(2012) David R. Myers et al.   Jove-Journal of Visualized Experiments

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Applications of electrowetting-based digital microfluidics in clinical diagnostics

(2011) Michael G Pollack et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Beyond PDMS: off-stoichiometry thiol–ene (OSTE) based soft lithography for rapid prototyping of microfluidic devices

(2011) Carl Fredrik Carlborg et al.   LAB ON A CHIP

High-resolution dose-response screening using droplet-based microfluidics

(2011) O. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Droplet microfluidics with magnetic beads: a new tool to investigate drug–protein interactions

(2010) Dario Lombardi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Body-on-a chip: Using microfluidic systems to predict human responses to drugs

(2010) Michael L. Shuler et al.   PURE AND APPLIED CHEMISTRY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biofabrication of a three-dimensional liver micro-organ as anin vitrodrug metabolism model

(2010) Robert Chang et al.   Biofabrication

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Butyl Methacrylate Monolithic Column Prepared In-Situ on a Microfluidic Chip and its Applications

(2009) Yi Xu et al.   SENSORS

The challenge of selecting protein kinase assays for lead discovery optimization

(2008) Haiching Ma et al.   Expert Opinion on Drug Discovery

How to exploit the features of microfluidics technology

(2007)   LAB ON A CHIP

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS