Article
Biochemical Research Methods
Pallavi Shinde, Ashwini Shinde, Srabani Kar, Kavitha Illath, Moeto Nagai, Fan-Gang Tseng, Tuhin Subhra Santra
Summary: This study presents a novel and efficient technique for cell patterning and precise delivery of biomolecules into cells. It achieves highly efficient cell patterns and uniform transfection of biomolecules, making it a promising tool for therapeutics and diagnostics.
Review
Chemistry, Analytical
Ziyu Chen, Jeong-Bong Lee
Summary: SU-8, an epoxy-based negative-tone photoresist, has been widely used in fabricating biomedical devices. Despite its not complete biocompatibility, existing surface modification techniques can minimize biofouling. With proper treatments and surface modifications, SU-8 can be a unique choice for biomedical device fabrication.
Review
Chemistry, Multidisciplinary
Coralie Greant, Bo van Durme, Jasper van Hoorick, Sandra van Vlierberghe
Summary: Multiphoton lithography (MPL) is a powerful and useful tool for creating complex 2D and 3D micro- and nanostructures with high spatial resolution. This technology has gained significant interest in tissue engineering and medical device manufacturing due to its ability to generate sophisticated structures not achievable through traditional printing methods. This review discusses the use of two-photon photoinitiators (PIs) and photoreactive biomaterials in biomedical applications and provides an overview of MPL's applications in tissue engineering, biomedical devices, and photodynamic therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Automation & Control Systems
A. P. Ajay, Amitava DasGupta, Dhiman Chatterjee
Summary: Transdermal drug delivery using hollow microneedles is made possible by the use of a single-step spin coating process to achieve the desired thickness of a biocompatible photopolymer, SU-8, while using UV lithography to create a monolithic microneedle array. The fabricated microneedles exhibit robust mechanical properties and low resistance to fluid flow, making them suitable for drug delivery applications.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Mahsa Lotfi Marchoubeh, Samuel J. Cobb, Miguel Abrego Tello, Mengjia Hu, Andrea Jaquins-Gerstl, Elaine M. Robbins, Julie V. Macpherson, Adrian C. Michael, Ingrid Fritsch
Summary: The SU-8 probe with an array of nine individually addressable gold microband electrodes was used for detecting low concentrations of chemicals and studying biological tissues. The probe, flexible but sharp, could be inserted into soft tissue without noticeable damage. Redox cycling using adjacent electrodes allowed signal amplification without background subtraction, providing information on electrochemical mechanisms and kinetics. Detection limits for specific compounds were successfully obtained.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Pooria Golvari, Stephen M. Kuebler
Summary: This review surveys the advances in fabricating functional microdevices using multi-photon lithography (MPL) with the SU-8 material system, focusing on the progress made in the last five years and discussing methods for improving resolution and functionalizing structures after fabrication.
Article
Engineering, Manufacturing
Jia Deng, Lan Jiang, Bing Si, Huimin Zhou, Jingyan Dong, Pual Cohen
Summary: The study demonstrated the effectiveness of ultrasonic vibration assisted AFM-based nanomachining in fabricating 3D master nanotemplates for 3D soft lithography. The quality and reusability of the master nanotemplates were investigated, and the quality of the PDMS patterns was assessed by quantifying the volume differences using an automatic imaging registration algorithm.
JOURNAL OF MANUFACTURING PROCESSES
(2021)
Article
Chemistry, Physical
George H. Major, Sean C. Chapman, Jeffrey T. Chapman, Joshua I. Wheeler, Shiladitya Chatterjee, Cody V. Cushman, Daniel H. Ess, Matthew R. Linford
Summary: SU-8 is an important, epoxy-based, negative photoresist that can create high aspect ratio features. Spectroscopic ellipsometry (SE) is a nondestructive analytical technique that can be performed in the open air. In this study, different models were used to fit the SE measurement data of SU-8, with the B-spline model showing the lowest mean squared error. Additionally, time-dependent density functional theory (TD-DFT) modeling was found to be consistent with the measured optical function of SU-8.
SURFACE AND INTERFACE ANALYSIS
(2021)
Article
Physics, Multidisciplinary
T. Salpavaara, T. Joki, A. Skogberg, M. T. Calejo, J. Lekkala, S. Narkilahti, P. Kallio
Summary: This study developed microfabricated porous membranes to facilitate innervation in 3D cell culture models. Through experiments, it was found that the new membranes could support the growth of human pluripotent stem cell (hPSC)-derived neurons, leading to the formation of dense neural networks.
JOURNAL OF PHYSICS COMMUNICATIONS
(2021)
Proceedings Paper
Materials Science, Characterization & Testing
Ali Hosseinpour Shafaghi, Basit Abdul, Rayan Bajwa, Farid Sayar Irani, Murat Kaya Yapici
Summary: This paper presents the design and fabrication of SU-8 based thermal bimorph actuators that have fast response and low power consumption, making them suitable for underwater applications.
2023 SYMPOSIUM ON DESIGN, TEST, INTEGRATION & PACKAGING OF MEMS/MOEMS, DTIP
(2023)
Article
Chemistry, Physical
David R. Myers, Yongzhi Qiu, Meredith E. Fay, Michael Tennenbaum, Daniel Chester, Jonas Cuadrado, Yumiko Sakurai, Jong Baek, Reginald Tran, Jordan C. Ciciliano, Byungwook Ahn, Robert G. Mannino, Silvia T. Bunting, Carolyn Bennett, Michael Briones, Alberto Fernandez-Nieves, Michael L. Smith, Ashley C. Brown, Todd Sulchek, Wilbur A. Lam
Article
Multidisciplinary Sciences
Meredith E. Fay, David R. Myers, Amit Kumar, Cory T. Turbyfield, Rebecca Byler, Kaci Crawford, Robert G. Mannino, Alvin Laohapant, Erika A. Tyburski, Yumiko Sakurai, Michael J. Rosenbluth, Neil A. Switz, Todd A. Sulchek, Michael D. Graham, Wilbur A. Lam
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biotechnology & Applied Microbiology
Reginald Tran, David R. Myers, Gabriela Denning, Jordan E. Shields, Allison M. Lytle, Hommood Alrowais, Yongzhi Qiu, Yumiko Sakurai, William C. Li, Oliver Brand, Joseph M. Le Doux, H. Trent Spencer, Christopher B. Doering, Wilbur A. Lam
Article
Multidisciplinary Sciences
Yongzhi Qiu, Sheng Tong, Linlin Zhang, Yumiko Sakurai, David R. Myers, Lin Hong, Wilbur A. Lam, Gang Bao
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Yumiko Sakurai, Elaissa T. Hardy, Byungwook Ahn, Reginald Tran, Meredith E. Fay, Jordan C. Ciciliano, Robert G. Mannino, David R. Myers, Yongzhi Qiu, Marcus A. Carden, W. Hunter Baldwin, Shannon L. Meeks, Gary E. Gilbert, Shawn M. Jobe, Wilbur A. Lam
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
David R. Myers, Alexander Weiss, Margo R. Rollins, Wilbur A. Lam
SCIENTIFIC REPORTS
(2017)
Review
Hematology
Evelyn Kendall Williams, Oluwamayokun Oshinowo, Abhijit Ravindran, Wilbur A. Lam, David R. Myers
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2019)
Article
Multidisciplinary Sciences
Robert G. Mannino, David R. i Myers, Erika A. Tyburski, Christina Caruso, Jeanne Boudreaux, Traci Leong, G. D. Clifford, Wilbur A. Lam
NATURE COMMUNICATIONS
(2018)
Review
Nanoscience & Nanotechnology
Yongzhi Qiu, David R. Myers, Wilbur A. Lam
NATURE REVIEWS MATERIALS
(2019)
Article
Cell Biology
Oluwamayokun Oshinowo, Tamara Lambert, Yumiko Sakurai, Renee Copeland, Caroline E. Hansen, Wilbur A. Lam, David R. Myers
Article
Multidisciplinary Sciences
Ashkan Ojaghi, Gabriel Carrazana, Christina Caruso, Asad Abbas, David R. Myers, Wilbur A. Lam, Francisco E. Robles
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Yueyi Sun, Oluwamayokun Oshinowo, David R. Myers, Wilbur A. Lam, Alexander Alexeev
Summary: Blood clot contraction plays a crucial role in wound healing and hemostasis. This study investigates the relationship between single platelet forces and macroscopic clot forces, providing insights into blood disorders associated with bleeding and thrombosis. The findings contribute to the development of platelet-based biomaterials and facilitate the understanding of clotting mechanisms.
Article
Biochemical Research Methods
P. Delgado, O. Oshinowo, M. E. Fay, C. A. Luna, A. Dissanayaka, P. Dorbala, A. Ravindran, L. Shen, D. R. Myers
Summary: Integrating microfluidic mixers into lab-on-a-chip devices is challenging but important. The presented universal dry-film microfluidic mixing sticker can retrofit pre-existing microfluidics and maintain high performance. It utilizes laser-cut silicone-adhesive-coated polymer sheets to create complex designs that can be adhered to various surfaces, allowing easy assembly of the traditional F-mixer and a novel spiral F-mixer. The technology has numerous applications in point-of-care devices, microphysiological systems, and biomedical research.
Article
Engineering, Biomedical
Muhymin Islam, Abhishek Raj, Brynn McFarland, Hannah Maxine Brink, Jordan Ciciliano, Meredith Fay, David Richard Myers, Christopher Flowers, Edmund K. Waller, Wilbur Lam, Alexander Alexeev, Todd Sulchek
APL BIOENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Caroline E. Hansen, David R. Myers, W. Hunter Baldwin, Yumiko Sakurai, Shannon L. Meeks, L. Andrew Lyon, Wilbur A. Lam