Molecular analysis of circulating tumour cells—biology and biomarkers
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Title
Molecular analysis of circulating tumour cells—biology and biomarkers
Authors
Keywords
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Journal
Nature Reviews Clinical Oncology
Volume 11, Issue 3, Pages 129-144
Publisher
Springer Nature
Online
2014-01-21
DOI
10.1038/nrclinonc.2013.253
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Note: Only part of the references are listed.- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
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- (2013) Yi Liu et al. BMC CANCER
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- (2013) D J E Peeters et al. BRITISH JOURNAL OF CANCER
- Tumor Dissemination: An EMT Affair
- (2013) Jean Paul Thiery et al. CANCER CELL
- Circulating tumor cells as therapy-related biomarkers in cancer patients
- (2013) Tobias M. Gorges et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs
- (2013) Francesco Fabbri et al. CANCER LETTERS
- Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
- (2013) E. Heitzer et al. CANCER RESEARCH
- Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes
- (2013) Maki Kurokawa et al. CANCER SCIENCE
- Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
- (2013) Dan A. Landau et al. CELL
- Personalized Cancer Medicine: Molecular Diagnostics, Predictive biomarkers, and Drug Resistance
- (2013) D Gonzalez de Castro et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Detection of Circulating Tumor Cells Harboring a Unique ALK Rearrangement in ALK-Positive Non–Small-Cell Lung Cancer
- (2013) Emma Pailler et al. JOURNAL OF CLINICAL ONCOLOGY
- Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells
- (2013) Maria Chimonidou et al. MOLECULAR CANCER RESEARCH
- Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
- (2013) Helen Schneck et al. Molecular Oncology
- Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
- (2013) Muhammed Murtaza et al. NATURE
- Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
- (2013) Irène Baccelli et al. NATURE BIOTECHNOLOGY
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- (2013) Emily Crowley et al. Nature Reviews Clinical Oncology
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- (2013) Leticia De Mattos-Arruda et al. Nature Reviews Clinical Oncology
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- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer
- (2013) Alice T. Shaw et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2013) Sarah-Jane Dawson et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2013) Thierry Voet et al. NUCLEIC ACIDS RESEARCH
- SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance
- (2013) Soyoung Lim et al. PLoS One
- Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
- (2013) X. Ni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer
- (2013) Chun-Liang Chen et al. PROSTATE
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- (2013) M. Yu et al. SCIENCE
- Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells
- (2013) E. Ozkumur et al. Science Translational Medicine
- The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis
- (2013) L. Zhang et al. Science Translational Medicine
- ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma
- (2012) M. Ilie et al. ANNALS OF ONCOLOGY
- Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor
- (2012) T. J. N. Hiltermann et al. ANNALS OF ONCOLOGY
- Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials
- (2012) François-Clément Bidard et al. CANCER AND METASTASIS REVIEWS
- Intratumor Heterogeneity: Evolution through Space and Time
- (2012) C. Swanton CANCER RESEARCH
- The Genetic Basis for Cancer Treatment Decisions
- (2012) Janet E. Dancey et al. CELL
- Evaluation of Circulating Tumor Cells and Circulating Tumor DNA in Non-Small Cell Lung Cancer: Association with Clinical Endpoints in a Phase II Clinical Trial of Pertuzumab and Erlotinib
- (2012) E. A. Punnoose et al. CLINICAL CANCER RESEARCH
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- (2012) L. A. Byers et al. CLINICAL CANCER RESEARCH
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- (2012) C. Gasch et al. CLINICAL CHEMISTRY
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- (2012) Mohid S. Khan et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2011) A Lecharpentier et al. BRITISH JOURNAL OF CANCER
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- (2011) Lot A. Devriese et al. CANCER TREATMENT REVIEWS
- Quantitative Detection of EGFR Mutations in Circulating Tumor DNA Derived from Lung Adenocarcinomas
- (2011) K. Taniguchi et al. CLINICAL CANCER RESEARCH
- Circulating tumor cells: approaches to isolation and characterization
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- (2011) Hisae Iinuma et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2011) Matthew G. Krebs et al. JOURNAL OF CLINICAL ONCOLOGY
- Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches
- (2011) Matthew G. Krebs et al. Journal of Thoracic Oncology
- Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP)
- (2011) Hui-Sung Moon et al. LAB ON A CHIP
- Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
- (2011) Caicun Zhou et al. LANCET ONCOLOGY
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- (2011) A. J. Armstrong et al. MOLECULAR CANCER RESEARCH
- Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells
- (2011) J. M. Stewart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
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- (2010) C. M. Bateman et al. BLOOD
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- (2010) L M Flores et al. BRITISH JOURNAL OF CANCER
- Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine
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- (2010) E. Rossi et al. CLINICAL CANCER RESEARCH
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- (2010) Y. Jiang et al. CLINICAL CHEMISTRY
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- (2010) Jaco Kraan et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
- (2010) Wendy De Roock et al. LANCET ONCOLOGY
- Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis
- (2010) Qicheng Zhao et al. Molecular Cancer
- Genetic variegation of clonal architecture and propagating cells in leukaemia
- (2010) Kristina Anderson et al. NATURE
- Genome remodelling in a basal-like breast cancer metastasis and xenograft
- (2010) Li Ding et al. NATURE
- Distant metastasis occurs late during the genetic evolution of pancreatic cancer
- (2010) Shinichi Yachida et al. NATURE
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- (2010) Richard L. Schilsky NATURE REVIEWS DRUG DISCOVERY
- Malignant cells facilitate lung metastasis by bringing their own soil
- (2010) D. G. Duda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
- (2010) S. L. Stott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays
- (2010) A.-E. Saliba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer
- (2010) S. L. Stott et al. Science Translational Medicine
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- (2009) Joost F. Swennenhuis et al. CYTOMETRY PART A
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- (2009) Peter R. C. Gascoyne et al. ELECTROPHORESIS
- Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients
- (2009) Janice Lu et al. INTERNATIONAL JOURNAL OF CANCER
- EMT: When epithelial cells decide to become mesenchymal-like cells
- (2009) Raghu Kalluri JOURNAL OF CLINICAL INVESTIGATION
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2009) Ultan McDermott et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2009) Nikolaos Xenidis et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2009) Gursah Kats-Ugurlu et al. JOURNAL OF PATHOLOGY
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- (2009) Fuchou Tang et al. NATURE METHODS
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- (2009) Tony S. Mok et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) A. H. Talasaz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) K. S. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) C. Gjerdrum et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) Kunihiko Hiraiwa et al. ANNALS OF SURGICAL ONCOLOGY
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- (2008) Adam L Asare et al. BMC GENOMICS
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- (2008) T. Tsuji et al. CANCER RESEARCH
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- (2008) Sendurai A. Mani et al. CELL
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- (2008) A. Soltermann et al. CLINICAL CANCER RESEARCH
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- (2008) Steven J. Cohen et al. JOURNAL OF CLINICAL ONCOLOGY
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