Arginine dependence of tumor cells: targeting a chink in cancer’s armor

Final results of phase II trial of pegylated arginine deiminase (ADI-PEG20) in metastatic melanoma (MM).

(2017) L. G. Feun et al.   JOURNAL OF CLINICAL ONCOLOGY

Chromatophagy: Autophagy goes nuclear and captures broken chromatin during arginine-starvation

(2015) Hsing-Jien Kung et al.   Autophagy

Endothelial Metabolism Driving Angiogenesis

(2015) Anna Rita Cantelmo et al.   CANCER JOURNAL

PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida

(2015) Long Zhang et al.   CANCER LETTERS

Targeting arginine metabolism pathway to treat arginine-dependent cancers

(2015) Fuming Qiu et al.   CANCER LETTERS

Metabolic control of the cell cycle

(2015) Joanna Kalucka et al.   CELL CYCLE

VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates AngiogenesisNovelty and Significance

(2015) Aránzazu Chamorro-Jorganes et al.   CIRCULATION RESEARCH

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors

(2015) B. K. Tomlinson et al.   CLINICAL CANCER RESEARCH

Metabolic pathway compartmentalization: an underappreciated opportunity?

(2015) Annalisa Zecchin et al.   CURRENT OPINION IN BIOTECHNOLOGY

Arginine deprivation in cancer therapy

(2015) Lynn G. Feun et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

(2015) Oula Khoury et al.   JOURNAL OF NEURO-ONCOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

(2015) Mitsuyo Ohmura et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

(2015) Niramol Savaraj et al.   Oncotarget

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling

(2014) Jiangbo Liu et al.   BMC CANCER

Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

(2014) Jennifer A McAlpine et al.   BMC CANCER

Recombinant arginine-degrading enzymes in metabolic anticancer therapy and bioanalytics

(2014) Oleh V. Stasyk et al.   CELL BIOLOGY INTERNATIONAL

The multifaceted activity of VEGF in angiogenesis – Implications for therapy responses

(2014) Stijn Moens et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

(2014) Anna Synakiewicz et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism

(2014) Peter Stapor et al.   JOURNAL OF CELL SCIENCE

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer

(2014) Rouzbeh Daylami et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

(2014) Naoharu Takano et al.   MOLECULAR CANCER RESEARCH

Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas

(2014) T Gelb et al.   ONCOGENE

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

(2014) N Cetinbas et al.   ONCOGENE

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

(2014) D Zhao et al.   ONCOGENE

Autophagy regulates tissue overgrowth in a context-dependent manner

(2014) E Pérez et al.   ONCOGENE

Amino Acids and Immune Response: A Role for Cysteine, Glutamine, Phenylalanine, Tryptophan and Arginine in T-cell Function and Cancer?

(2014) Angelos K. Sikalidis   PATHOLOGY & ONCOLOGY RESEARCH

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

(2014) Chun A. Changou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered Human Arginase I with Enhanced Activity and Stability Controls Hepatocellular and Pancreatic Carcinoma Xenografts

(2014) Evan S. Glazer et al.   Translational Oncology

Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells

(2014) Z Wang et al.   Cell Death & Disease

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

(2014) Melissa M. Phillips et al.   Cancer Research and Treatment

Control of the translational machinery by amino acids

(2013) Christopher G Proud   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS

(2013) Shawn Elms et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell proliferation, potassium channels, polyamines and their interactions: a mini review

(2013) Thomas M. Weiger et al.   AMINO ACIDS

Functional amino acids in nutrition and health

(2013) Guoyao Wu   AMINO ACIDS

Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells

(2013) Ziyu Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets

(2013) Jianzhou Cui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumor cell-mediated neovascularization and lymphangiogenesis contrive tumor progression and cancer metastasis

(2013) Zhifei Cao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

(2013) M. D. Allen et al.   CANCER RESEARCH

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

(2013) H.-Y. Huang et al.   CLINICAL CANCER RESEARCH

Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis

(2013) Peter Fraisl   EXPERIMENTAL CELL RESEARCH

Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase

(2013) Peter W. Szlosarek et al.   JOURNAL OF CLINICAL ONCOLOGY

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

(2013) Rita Tanios et al.   LEUKEMIA RESEARCH

Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence, and Glutamine Addiction

(2013) Yan Long et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy: A critical regulator of cellular metabolism and homeostasis

(2013) Stefan W. Ryter et al.   MOLECULES AND CELLS

Translation factors and ribosomal proteins control tumor onset and progression: how?

(2013) F Loreni et al.   ONCOGENE

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

(2013) S. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in tumour cell death

(2013) Robin L. Macintosh et al.   SEMINARS IN CANCER BIOLOGY

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

(2013) N Syed et al.   Cell Death & Disease

Leucine and mTORC1: a complex relationship

(2012) Kayleigh M. Dodd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary requirements of “nutritionally non-essential amino acids” by animals and humans

(2012) Guoyao Wu et al.   AMINO ACIDS

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

(2012) Rósula García-Navas et al.   Autophagy

A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells

(2012) Philippe Icard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

(2012) L G Feun et al.   BRITISH JOURNAL OF CANCER

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming

(2012) Shuo Qie et al.   CELL CYCLE

Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives

(2012) Patrick Raber et al.   IMMUNOLOGICAL INVESTIGATIONS

What Occurs by Replacing Mn2+ with Co2+ in Human Arginase I: First-Principles Computational Analysis

(2012) Tiziana Marino et al.   INORGANIC CHEMISTRY

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

(2012) Patrick A. Ott et al.   INVESTIGATIONAL NEW DRUGS

Deprivation of arginine by recombinant human arginase in prostate cancer cells

(2012) Eddy C Hsueh et al.   Journal of Hematology & Oncology

Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia

(2012) K Morrow et al.   LEUKEMIA

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

(2012) Min You et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

(2012) Brian M. Polster   NEUROCHEMISTRY INTERNATIONAL

Upregulation of amino acid transporter expression induced by l-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanism

(2012) Jun-qiu Luo et al.   NUTRITION

Ambra1 at the crossroad between autophagy and cell death

(2012) G M Fimia et al.   ONCOGENE

Metabolic reprogramming of the tumor

(2012) L M R Ferreira et al.   ONCOGENE

The evolution of the TOR pathway and its role in cancer

(2012) E M Beauchamp et al.   ONCOGENE

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Arginine deprivation as a new treatment strategy for head and neck cancer

(2012) Cheng-Chih Huang et al.   ORAL ONCOLOGY

Amino acid sensing and regulation of mTORC1

(2012) Lijun Yan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

(2012) B Delage et al.   Cell Death & Disease

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells

(2012) Michael S. Kilberg et al.   Advances in Nutrition

Autophagic cell death: Loch Ness monster or endangered species?

(2011) Han-Ming Shen et al.   Autophagy

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

(2011) M P Kelly et al.   BRITISH JOURNAL OF CANCER

Apoptosis: why and how does it occur in biology?

(2011) Engin Ulukaya et al.   CELL BIOCHEMISTRY AND FUNCTION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Metabolic Flux and the Regulation of Mammalian Cell Growth

(2011) Jason W. Locasale et al.   Cell Metabolism

Targeting methionine auxotrophy in cancer: discovery & exploration

(2011) Vaidehi Agrawal et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming

(2011) C H Eng et al.   ONCOGENE

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

Agmatine (decarboxylated l-arginine): Physiological role and therapeutic potential

(2011) Gerhard J. Molderings et al.   PHARMACOLOGY & THERAPEUTICS

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Replacing Mn2+with Co2+in Human Arginase I Enhances Cytotoxicity towardl-Arginine Auxotrophic Cancer Cell Lines

(2010) Everett M. Stone et al.   ACS Chemical Biology

The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines

(2010) Min You et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pegylated arginase I: a potential therapeutic approach in T-ALL

(2010) C. P. Hernandez et al.   BLOOD

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

(2010) T-S Yang et al.   BRITISH JOURNAL OF CANCER

Cancer cell sensitivity to arginine deprivationin vitrois not determined by endogenous levels of arginine metabolic enzymes

(2010) Yaroslav P Bobak et al.   CELL BIOLOGY INTERNATIONAL

Mitochondrial control of caspase-dependent and -independent cell death

(2010) Ludivine A. Pradelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Arginine Deprivation, Autophagy, Apoptosis (AAA) for the Treatment of Melanoma

(2010) N. Savaraj et al.   CURRENT MOLECULAR MEDICINE

Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment

(2010) Aude Carreau et al.   EXPERIMENTAL CELL RESEARCH

Phase II Study of Pegylated Arginine Deiminase for Nonresectable and Metastatic Hepatocellular Carcinoma

(2010) Evan S. Glazer et al.   JOURNAL OF CLINICAL ONCOLOGY

Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma

(2010) E. Kobayashi et al.   MOLECULAR CANCER THERAPEUTICS

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

(2010) M Djavaheri-Mergny et al.   ONCOGENE

Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis

(2010) Tin-Lun Lam et al.   Pigment Cell & Melanoma Research

Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1

(2010) Evan S. Glazer et al.   SURGERY

l-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells

(2009) Bie Tan et al.   AMINO ACIDS

ADI, autophagy and apoptosis: Metabolic stress as a therapeutic option for prostate cancer

(2009) Randie H. Kim et al.   Autophagy

Arginine deiminase originating from Lactococcus lactis ssp. lactis American Type Culture Collection (ATCC) 7962 induces G1-phase cell-cycle arrest and apoptosis in SNU-1 stomach adenocarcinoma cells

(2009) Jong-Eun Kim et al.   BRITISH JOURNAL OF NUTRITION

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC)

(2009) Sam-Mui Tsui et al.   Cancer Cell International

Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest

(2009) T.L. Lam et al.   CANCER LETTERS

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

(2009) Linda J. Nicholson et al.   INTERNATIONAL JOURNAL OF CANCER

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1 /Sp4

(2009) W.-B. Tsai et al.   MOLECULAR CANCER THERAPEUTICS

Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation

(2008) S. S. Palii et al.   AMINO ACIDS

Arginine metabolism and nutrition in growth, health and disease

(2008) Guoyao Wu et al.   AMINO ACIDS

The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes

(2008) Eleonore S Köhler et al.   BMC DEVELOPMENTAL BIOLOGY

Arginine deiminase, a potential anti-tumor drug

(2008) Ye Ni et al.   CANCER LETTERS

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

(2008) Tawnya L. Bowles et al.   INTERNATIONAL JOURNAL OF CANCER

Perivascular nitric oxide gradients normalize tumor vasculature

(2008) Satoshi Kashiwagi et al.   NATURE MEDICINE

Role of arginine metabolism in immunity and immunopathology

(2007) Elisa Peranzoni et al.   IMMUNOBIOLOGY

Characterization of Arginine Decarboxylase in Rat Brain and Liver

(2003) S. Regunathan et al.   JOURNAL OF NEUROCHEMISTRY