Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer

Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy

(2015) Carolina Bizama et al.   CANCER TREATMENT REVIEWS

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

The multifaceted regulation and functions of PKM2 in tumor progression

(2014) Zongwei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Aspects on gallbladder cancer in 2014

(2014) Åke Andrén-Sandberg et al.   CURRENT OPINION IN GASTROENTEROLOGY

Activators of PKM2 in cancer metabolism

(2014) Steven L Warner et al.   Future Medicinal Chemistry

Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor Growth by Promoting Angiogenesis

(2014) Liangwei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression patterns of three regulation enzymes in glycolysis in esophageal squamous cell carcinoma: association with survival

(2014) Wenfeng Li et al.   MEDICAL ONCOLOGY

Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression

(2013) Ivan Nemazanyy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer

(2013) J. Li et al.   Clinical & Translational Oncology

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer

(2013) Maolan Li et al.   TUMOR BIOLOGY

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

(2012) Oh-Hyung Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma

(2012) Chengguo Wang et al.   Diagnostic Pathology

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

(2012) Michael S. Goldberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells

(2012) Zhujun Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells

(2012) Wenjuan Li et al.   MOLECULAR CARCINOGENESIS

The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

(2010) Stephen B. Edge et al.   ANNALS OF SURGICAL ONCOLOGY

Management of Gallbladder Cancer

(2010) Shiva Jayaraman et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect

(2009) C. V. Dang   Science Signaling

Surgical Management of Gallbladder Cancer

(2009) Srinevas K. Reddy et al.   Surgical Oncology Clinics of North America

Gallbladder cancer

(2008) Stavros Gourgiotis et al.   AMERICAN JOURNAL OF SURGERY

Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling

(2008) Thian-Sze Wong et al.   INTERNATIONAL JOURNAL OF CANCER