Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset

(2015) Jason P. Berninger et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The potential of AOP networks for reproductive and developmental toxicity assay development

(2015) Dries Knapen et al.   REPRODUCTIVE TOXICOLOGY

Waterborne beclomethasone dipropionate affects the physiology of fish while its metabolite beclomethasone is not taken up

(2015) Bethanie M. Carney Almroth et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment

(2015) Miyoung Yoon et al.   TOXICOLOGY

An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessment, monitoring and advanced research

(2014) Daniel J. Caldwell et al.   CHEMOSPHERE

Quantitative Cross-Species Extrapolation between Humans and Fish: The Case of the Anti-Depressant Fluoxetine

(2014) Luigi Margiotta-Casaluci et al.   PLoS One

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

An evolutionarily conserved program of B-cell development and activation in zebrafish

(2013) D. M. Page et al.   BLOOD

Metabolic and Reproductive Effects of Relatively Low Concentrations of Beclomethasone Dipropionate, a Synthetic Glucocorticoid, on Fathead Minnows

(2013) Subramaniam Kugathas et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Progesterone Alters Global Transcription Profiles at Environmental Concentrations in Brain and Ovary of Female Zebrafish (Danio rerio)

(2013) Sara Zucchi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoid receptor signaling in health and disease

(2013) Mahita Kadmiel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mode of action of human pharmaceuticals in fish: The effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study

(2012) Luigi Margiotta-Casaluci et al.   AQUATIC TOXICOLOGY

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

Progress and promises in toxicogenomics in aquatic toxicology: Is technical innovation driving scientific innovation?

(2011) Karl Fent et al.   AQUATIC TOXICOLOGY

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone

(2011) Zhenhong Li et al.   BMC Systems Biology

Pharmacokinetics, Pharmacodynamics, and Comparative Bioavailability of Single, Oral 2-mg Doses of Dexamethasone Liquid and Tablet Formulations: A Randomized, Controlled, Crossover Study in Healthy Adult Volunteers

(2011) Christian Queckenberg et al.   CLINICAL THERAPEUTICS

Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development

(2011) Carlie A. LaLone et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

(2010) Karen H. Watanabe et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Reverse engineering adverse outcome pathways

(2010) Edward J. Perkins et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals

(2010) Beate I Escher et al.   Integrated Environmental Assessment and Management

Advancing environmental toxicology through chemical dosimetry: External exposures versus tissue residues

(2010) LS McCarty et al.   Integrated Environmental Assessment and Management

Exposure science and the U.S. EPA National Center for Computational Toxicology

(2008) Elaine A Cohen Hubal et al.   Journal of Exposure Science and Environmental Epidemiology

Genomic Signatures and Dose-Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES