How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Computational model of the fathead minnow hypothalamic–pituitary–gonadal axis: Incorporating protein synthesis in improving predictability of responses to endocrine active chemicals

(2016) Miyuki Breen et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

(2016) Justin G. Teeguarden et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics

(2016) Karen H. Watanabe et al.   PLoS One

Large-Scale Predictive Drug Safety: From Structural Alerts to Biological Mechanisms

(2015) Ricard Garcia-Serna et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

(2015) Julie K. Buick et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Linking mechanistic toxicology to population models in forecasting recovery from chemical stress: A case study from Jackfish Bay, Ontario, Canada

(2015) David H. Miller et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Evaluation of combinations ofin vitrosensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization

(2015) Morihiko Hirota et al.   JOURNAL OF APPLIED TOXICOLOGY

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

(2015) Osamu Takenouchi et al.   JOURNAL OF APPLIED TOXICOLOGY

Prediction of human population responses to toxic compounds by a collaborative competition

(2015) Federica Eduati et al.   NATURE BIOTECHNOLOGY

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

(2015) Edward J. Perkins et al.   TOXICOLOGICAL SCIENCES

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

(2015) M.E. (Bette) Meek et al.   TOXICOLOGY

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

(2015) Kerstin Reisinger et al.   TOXICOLOGY IN VITRO

Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

(2015) Annie Lumen et al.   Frontiers in Pharmacology

Inter-species prediction of protein phosphorylation in the sbv IMPROVER species translation challenge

(2014) M. Biehl et al.   BIOINFORMATICS

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

(2014) Kahn Rhrissorrakrai et al.   BIOINFORMATICS

Applying machine learning techniques for ADME-Tox prediction: a review

(2014) Vinícius Gonçalves Maltarollo et al.   Expert Opinion on Drug Metabolism & Toxicology

Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

(2014) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

(2014) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

(2013) Reuben Thomas et al.   PLoS One

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

(2013) M.E. (Bette) Meek et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling

(2013) Miyuki Breen et al.   TOXICOLOGICAL SCIENCES

Evaluation of Iodide Deficiency in the Lactating Rat and Pup Using a Biologically Based Dose-Response Model*

(2013) Jeffrey W. Fisher et al.   TOXICOLOGICAL SCIENCES

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification

(2012) P. Meyer et al.   BIOINFORMATICS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Upstream adverse effects in risk assessment: A model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans

(2012) Amber Wise et al.   ENVIRONMENTAL RESEARCH

Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans

(2012) Fred Parham et al.   ENVIRONMENTAL RESEARCH

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone

(2011) Zhenhong Li et al.   BMC Systems Biology

A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish

(2011) Zhenhong Li et al.   CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES

Verification of systems biology research in the age of collaborative competition

(2011) Pablo Meyer et al.   NATURE BIOTECHNOLOGY

Impact of Low-Level Thyroid Hormone Disruption Induced by Propylthiouracil on Brain Development and Function

(2011) Mary E. Gilbert   TOXICOLOGICAL SCIENCES

Allergic contact dermatitis: A commentary on the relationship between T lymphocytes and skin sensitising potency

(2011) Ian Kimber et al.   TOXICOLOGY

Systems biology: Leading the revolution in ecotoxicology

(2010) Natàlia Garcia-Reyero et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose–response assessment for nongenotoxic carcinogens

(2010) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Determining Epidermal Disposition Kinetics for Use in an Integrated Nonanimal Approach to Skin Sensitization Risk Assessment

(2010) Michael Davies et al.   TOXICOLOGICAL SCIENCES

Thyroid disrupting chemicals: mechanisms and mixtures

(2008) Kevin M. Crofton   INTERNATIONAL JOURNAL OF ANDROLOGY

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH