Practical approaches to adverse outcome pathway development and weight-of-evidence evaluation as illustrated by ecotoxicological case studies

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

(2016) Justin G. Teeguarden et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A weight of evidence assessment approach for adverse outcome pathways

(2016) Zachary A. Collier et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Long-term exposure to fluoxetine reduces growth and reproductive potential in the dominant rocky intertidal mussel, Mytilus californianus

(2016) Joseph R. Peters et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Editor’s Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity

(2016) Carlie A. LaLone et al.   TOXICOLOGICAL SCIENCES

Comparison of Control of Pedal Sole Cilia in the Snails Lymnaea stagnalis appressa and Helisoma trivolvis

(2016) Roger D. Longley   BIOLOGICAL BULLETIN

Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers

(2015) Ping Gong et al.   Biomarkers in Medicine

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

The effects of antidepressants appear to be rapid and at environmentally relevant concentrations

(2015) Alex T. Ford et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos

(2015) Tara D. Raftery et al.   NEUROTOXICOLOGY AND TERATOLOGY

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The potential of AOP networks for reproductive and developmental toxicity assay development

(2015) Dries Knapen et al.   REPRODUCTIVE TOXICOLOGY

Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

(2015) Edward J. Perkins et al.   TOXICOLOGICAL SCIENCES

The Safety and Pharmacokinetics of Carprofen, Flunixin and Phenylbutazone in the Cape Vulture (Gyps coprotheres) following Oral Exposure

(2015) Tamsyn Fourie et al.   PLoS One

Cryptic and biochemical responses of young cuttlefish Sepia officinalis exposed to environmentally relevant concentrations of fluoxetine

(2014) Carole Di Poi et al.   AQUATIC TOXICOLOGY

Chronic fluoxetine exposure alters movement and burrowing in adult freshwater mussels

(2014) Peter D. Hazelton et al.   AQUATIC TOXICOLOGY

Diclofenac is toxic to the Steppe Eagle Aquila nipalensis: widening the diversity of raptors threatened by NSAID misuse in South Asia

(2014) ANIL K. SHARMA et al.   BIRD CONSERVATION INTERNATIONAL

Suspected flunixin poisoning of a wild Eurasian Griffon Vulture from Spain

(2014) Irene Zorrilla et al.   CONSERVATION BIOLOGY

Are Adverse Outcome Pathways Here to Stay?

(2014) Natàlia Garcia-Reyero   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Daphnia magna

(2014) Eri Sumiya et al.   Frontiers in Zoology

Chemical and protein structural basis for biological crosstalk between PPARα and COX enzymes

(2014) Ann E. Cleves et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Sex, epilepsy, and epigenetics

(2014) Irfan A. Qureshi et al.   NEUROBIOLOGY OF DISEASE

Sex dimorphism in seizure-controlling networks

(2014) Fillippo Sean Giorgi et al.   NEUROBIOLOGY OF DISEASE

T3DB: the toxic exposome database

(2014) David Wishart et al.   NUCLEIC ACIDS RESEARCH

Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals

(2014) T. H. Hutchinson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms

(2014) C. A. LaLone et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Avian scavengers and the threat from veterinary pharmaceuticals

(2014) R. J. Cuthbert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Effects of perinatal exposure to waterborne fluoxetine on memory processing in the cuttlefish Sepia officinalis

(2013) Carole Di Poi et al.   AQUATIC TOXICOLOGY

Behavioural and transcriptional changes in the amphipod Echinogammarus marinus exposed to two antidepressants, fluoxetine and sertraline

(2013) Maryline C. Bossus et al.   AQUATIC TOXICOLOGY

An exploratory investigation of various modes of action and potential adverse outcomes of fluoxetine in marine mussels

(2013) Silvia Franzellitti et al.   AQUATIC TOXICOLOGY

The biological effects of antidepressants on the molluscs and crustaceans: A review

(2013) Peter P. Fong et al.   AQUATIC TOXICOLOGY

The apparently very variable potency of the anti-depressant fluoxetine

(2013) J.P. Sumpter et al.   AQUATIC TOXICOLOGY

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of the insecticide fipronil on reproductive endocrinology in the fathead minnow

(2013) David C. Bencic et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish

(2013) Rakesh Kumar Banote et al.   EPILEPSY & BEHAVIOR

SMPDB 2.0: Big Improvements to the Small Molecule Pathway Database

(2013) Timothy Jewison et al.   NUCLEIC ACIDS RESEARCH

Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish

(2013) Anna Maria Siebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fluoxetine alters adult freshwater mussel behavior and larval metamorphosis

(2013) Peter D. Hazelton et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Study of potential toxic effects of acetylsalicylic acid upon short-term repeated oral administration in chickens

(2012) K. Mohan et al.   JOURNAL OF APPLIED ANIMAL RESEARCH

Sexual differences in serotonin distribution and induction of synchronous larval release by serotonin in the freshwater mussel Hyriopsis bialatus

(2012) Penjun Meechonkit et al.   JOURNAL OF MOLLUSCAN STUDIES

Antidepressants (venlafaxine and citalopram) cause foot detachment from the substrate in freshwater snails at environmentally relevant concentrations

(2012) Peter P. Fong et al.   MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics

(2012) Douglas G. Howe et al.   NUCLEIC ACIDS RESEARCH

NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms

(2012) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties

(2011) Ann M. Tarrant et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

An epidermis-specific chitin synthase CDNA in Choristoneura fumiferana: cloning, characterization, developmental and hormonal-regulated expression

(2010) Dinakar R. Ampasala et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

The toxicokinetics of ketoprofen in Gyps coprotheres: toxicity due to zero-order metabolism

(2010) V. Naidoo et al.   ARCHIVES OF TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Development of light response and GABAergic excitation-to-inhibition switch in zebrafish retinal ganglion cells

(2010) Rong-wei Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sublethal toxicity of commercial insecticide formulations and their active ingredients to larval fathead minnow (Pimephales promelas)

(2010) Sebastian Beggel et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen

(2009) V. Naidoo et al.   Biology Letters

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Diclofenac-induced biochemical and histopathological changes in white leghorn birds (Gallus domesticus)

(2009) KM Koley et al.   INDIAN JOURNAL OF PHARMACOLOGY

SMPDB: The Small Molecule Pathway Database

(2009) Alex Frolkis et al.   NUCLEIC ACIDS RESEARCH

Veterinary diclofenac threatens Africa’s endangered vulture species

(2009) V. Naidoo et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Nephrotoxic cell death by diclofenac and meloxicam

(2008) Lin Eng Ng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

APPARENT TOLERANCE OF TURKEY VULTURES (CATHARTES AURA) TO THE NON-STEROIDAL ANTI-INFLAMMATORY DRUG DICLOFENAC

(2008) Barnett A. Rattner et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Clumping behavior as a strategy against drilling predation: Implications for the fossil record

(2008) Michelle M. Casey et al.   JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY

Molecular basis of the catch state in molluscan smooth muscles: a catchy challenge

(2008) Stefan Galler   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Adaptations to host infection and larval parasitism in Unionoida

(2008) M. Christopher Barnhart et al.   JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY

The pharmacokinetics of meloxicam in vultures

(2008) V. NAIDOO et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Induction of supernumerary larval moulting in the tobacco hornworm Manduca sexta: interaction of bisacylhydrazine ecdysteroid agonists with endogenous Juvenile Hormone

(2008) STUART E. REYNOLDS et al.   PHYSIOLOGICAL ENTOMOLOGY

Estradiol and the Developing Brain

(2008) MARGARET M. McCARTHY   PHYSIOLOGICAL REVIEWS