Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4

(2014) Peter C. J. Schmeits et al.   Toxicology Research

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Endoplasmic reticulum stress with low-dose cyclosporine in frequently relapsing nephrotic syndrome

(2013) Taketsugu Hama et al.   PEDIATRIC NEPHROLOGY

Toxicogenomics-Based Identification of Mechanisms for Direct Immunotoxicity

(2013) Jia Shao et al.   TOXICOLOGICAL SCIENCES

Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis

(2013) Anne S. Kienhuis et al.   TOXICOLOGY LETTERS

Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission

(2013) Gabriel de Arriba et al.   TOXICOLOGY LETTERS

DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells

(2013) Peter C.J. Schmeits et al.   TOXICOLOGY LETTERS

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes

(2012) Mirjam M. Schaap et al.   ARCHIVES OF TOXICOLOGY

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics

(2012) Peter C.J. Schmeits et al.   TOXICOLOGY LETTERS

Cyclosporin A induces the unfolded protein response in keratinocytes

(2011) Michiko Hibino et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair

(2011) Christiane Kuschal et al.   EXPERIMENTAL DERMATOLOGY

Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow

(2011) Ş. Remzi Erdem et al.   LIFE SCIENCES

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

(2011) C. Magkoufopoulou et al.   MUTAGENESIS

Cyclosporine A–Induced Oxidative Stress in Human Renal Mesangial Cells: A Role for ERK 1/2 MAPK Signaling

(2011) Séin O’Connell et al.   TOXICOLOGICAL SCIENCES

Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis

(2011) Madhumohan R. Katika et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

(2010) Andrzej Galat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immunosuppressant Neurotoxicity in Rat Brain Models: Oxidative Stress and Cellular Metabolism

(2010) Jelena Klawitter et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The NRF2–heme oxygenase-1 system modulates cyclosporin A-induced epithelial–mesenchymal transition and renal fibrosis

(2010) Dong-ha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptomic Profile Indicative of Immunotoxic Exposure: In Vitro Studies in Peripheral Blood Mononuclear Cells

(2010) Kevin Hochstenbach et al.   TOXICOLOGICAL SCIENCES

The effects of deoxynivalenol on gene expression in the murine thymus

(2010) Sandra W.M. van Kol et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Suppression of NF- B by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response

(2009) S. Du et al.   JOURNAL OF IMMUNOLOGY

Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo

(2008) Keiko Ohga et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells

(2008) Z. Bar-Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening

(2007) Kirsten A. Baken et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY