The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives

Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across

(2017) Fabian A. Grimm et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

(2016) Christopher A. Lipinski   ADVANCED DRUG DELIVERY REVIEWS

Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD)

(2016) João Barroso et al.   ARCHIVES OF TOXICOLOGY

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

(2016) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

(2016) Fabian A. Grimm et al.   GREEN CHEMISTRY

Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features

(2016) I. Tluczkiewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

In vitro screening for population variability in toxicity of pesticide-containing mixtures

(2015) Nour Abdo et al.   ENVIRONMENT INTERNATIONAL

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

(2015) Elisabet Berggren et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Prediction of human population responses to toxic compounds by a collaborative competition

(2015) Federica Eduati et al.   NATURE BIOTECHNOLOGY

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

A practical guidance for Cramer class determination

(2015) David W. Roberts et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment

(2015) Sneha Bhatia et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicokinetic Triage for Environmental Chemicals

(2015) John F. Wambaugh et al.   TOXICOLOGICAL SCIENCES

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment

(2015) Barbara A. Wetmore   TOXICOLOGY

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

(2015) Vinicius M. Alves et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

(2015) Vinicius M. Alves et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays

(2014) Yen Low et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Integrative Chemical–Biological Read-Across Approach for Chemical Hazard Classification

(2013) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants

(2013) Shengde Wu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of the Toxicity Forecasting Capability of EPA's ToxCast Phase I Data: Can ToxCast In Vitro Assays Predict Carcinogenicity?

(2013) ROMUALDO BENIGNI   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Use of category approaches, read-across and (Q)SAR: General considerations

(2013) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

(2012) D. M. Reif et al.   BIOINFORMATICS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

(2012) J. T. Fox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities

(2012) E. Fioravanzo et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data

(2012) Ivan Rusyn et al.   TOXICOLOGICAL SCIENCES

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

(2012) David J. Dix et al.   TOXICOLOGICAL SCIENCES

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

(2012) Eric F. Lock et al.   TOXICOLOGICAL SCIENCES

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

New Directions in Toxicity Testing

(2011) Daniel Krewski et al.   Annual Review of Public Health

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

(2011) Matthew T Martin et al.   BIOLOGY OF REPRODUCTION

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines

(2011) Kimiyo N. Yamamoto et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genetic toxicology in the 21st century: Reflections and future directions

(2011) Brinda Mahadevan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Predictingin vivosafety characteristics using physiochemical properties andin vitroassays

(2011) Nigel Greene et al.   Future Medicinal Chemistry

A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins

(2011) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

(2011) S.H. Doak et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Improvement of the Cramer classification for oral exposure using the database TTC RepDose – A strategy description

(2011) I. Tluczkiewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toward a Comprehensive Molecular Design Framework for Reduced Hazard

(2010) Adelina M. Voutchkova et al.   CHEMICAL REVIEWS

Computational Toxicology: Realizing the Promise of the Toxicity Testing 
in the 21st Century

(2010) Ivan Rusyn et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Future Use of in Vitro Data in Risk Assessment to Set Human Exposure Standards: Challenging Problems and Familiar Solutions

(2010) Kenny S. Crump et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Path to Personalized Medicine

(2010) Margaret A. Hamburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vitro Screening for Population Variability in Chemical Toxicity

(2010) Shannon H. O'Shea et al.   TOXICOLOGICAL SCIENCES

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity

(2009) M. Hewitt et al.   REPRODUCTIVE TOXICOLOGY

Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry

(2009) James S. MacDonald et al.   TOXICOLOGICAL SCIENCES

Quantitative and Mechanistic Read Across for Predicting the Skin Sensitization Potential of Alkenes Acting via Michael Addition

(2008) Steven James Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Toxicity Testing in the 21st Century: Bringing the Vision to Life

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES