Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

A powerful and flexible approach to the analysis of RNA sequence count data

(2011) Yi-Hui Zhou et al.   BIOINFORMATICS

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rare and Common Regulatory Variation in Population-Scale Sequenced Human Genomes

(2011) Stephen B. Montgomery et al.   PLoS Genetics

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Future Use of in Vitro Data in Risk Assessment to Set Human Exposure Standards: Challenging Problems and Familiar Solutions

(2010) Kenny S. Crump et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity

(2010) Alexander Sedykh et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Toxicogenetics: population-based testing of drug and chemical safety in mouse models

(2010) Ivan Rusyn et al.   PHARMACOGENOMICS

An enhanced tiered toxicity testing framework with triggers for assessing hazards and risks of commodity chemicals

(2010) Laura M. Plunkett et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In Vitro Screening for Population Variability in Chemical Toxicity

(2010) Shannon H. O'Shea et al.   TOXICOLOGICAL SCIENCES

Cirhin up-regulates a canonical NF-κB element through strong interaction with Cirip/HIVEP1

(2009) Bin Yu et al.   EXPERIMENTAL CELL RESEARCH

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

(2009) A. H. Harrill et al.   GENOME RESEARCH

Molecular karyotyping in 17 patients and mutation screening in 41 patients with Kabuki syndrome

(2009) Hideo Kuniba et al.   JOURNAL OF HUMAN GENETICS

Thioredoxin and thioredoxin reductase influence estrogen receptor α-mediated gene expression in human breast cancer cells

(2009) Abhi K Rao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

Identification of Chemical Compounds that Induce HIF-1α Activity

(2009) Menghang Xia et al.   TOXICOLOGICAL SCIENCES

Characterization of Diversity in Toxicity Mechanism Using in Vitro Cytotoxicity Assays in Quantitative High Throughput Screening

(2008) Ruili Huang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Robert J. Kavlock et al.   RISK ANALYSIS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

(2008) Edwin Choy et al.   PLoS Genetics