A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes

(2015) Fabian Alexander Grimm et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

(2015) Elisabet Berggren et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Building scientific confidence in the development and evaluation of read-across

(2015) G. Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Aligning the 3Rs with new paradigms in the safety assessment of chemicals

(2015) Natalie Burden et al.   TOXICOLOGY

Toxicogenomics in vitro as an alternative tool for safety evaluation of petroleum substances and PAHs with regard to prenatal developmental toxicity

(2015) Polyxeni Tsitou et al.   TOXICOLOGY IN VITRO

High-Content High-Throughput Assays for Characterizing the Viability and Morphology of Human iPSC-Derived Neuronal Cultures

(2014) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays

(2014) Yen Low et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Aryl Hydrocarbon Receptor Repressor and TiPARP (ARTD14) Use Similar, but also Distinct Mechanisms to Repress Aryl Hydrocarbon Receptor Signaling

(2014) Laura MacPherson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2

(2014) Caitlin W. Brown et al.   MOLECULAR CANCER RESEARCH

Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay

(2014) H. Benjamin Larman et al.   NUCLEIC ACIDS RESEARCH

The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an exemplary case study

(2014) Nicholas Ball et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish

(2014) F. Brette et al.   SCIENCE

Read-across approaches - misconceptions, promises and challenges ahead

(2014) Grace Patlewicz   ALTEX-Alternatives to Animal Experimentation

High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells

(2013) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Integrative Chemical–Biological Read-Across Approach for Chemical Hazard Classification

(2013) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Geologically distinct crude oils cause a common cardiotoxicity syndrome in developing zebrafish

(2013) Jee-Hyun Jung et al.   CHEMOSPHERE

Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

(2013) Mark Mercola et al.   CIRCULATION RESEARCH

Use of a Statistical Model to Predict the Potential for Repeated Dose and Developmental Toxicity of Dermally Administered Crude Oil and Relation to Reproductive Toxicity

(2013) Richard H. McKee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

The relationship between repeat-dose toxicity and aromatic-ring class profile of high-boiling petroleum substances

(2013) Randy N. Roth et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Use and validation of HT/HC assays to support 21st century toxicity evaluations

(2013) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the male and female reproductive toxicity of high-boiling petroleum substances

(2013) F. Jay Murray et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The relationship between developmental toxicity and aromatic-ring class profile of high-boiling petroleum substances

(2013) F. Jay Murray et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity

(2013) Oksana Sirenko et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

(2012) D. M. Reif et al.   BIOINFORMATICS

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data

(2012) Ivan Rusyn et al.   TOXICOLOGICAL SCIENCES

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker

(2011) Zhonglin Hao et al.   TUMOR BIOLOGY

The challenge of reproductive and developmental toxicology under REACH

(2008) Anthony R. Scialli   REGULATORY TOXICOLOGY AND PHARMACOLOGY