Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

A Curated Database of Rodent Uterotrophic Bioactivity

(2015) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Toxicokinetic Triage for Environmental Chemicals

(2015) John F. Wambaugh et al.   TOXICOLOGICAL SCIENCES

Defining Estrogenic Mechanisms of Bisphenol A Analogs through High Throughput Microscopy-Based Contextual Assays

(2014) Fabio Stossi et al.   CHEMISTRY & BIOLOGY

Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses

(2014) Daniel M. Rotroff et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

High Throughput Heuristics for Prioritizing Human Exposure to Environmental Chemicals

(2014) John F. Wambaugh et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

(2014) Ruili Huang et al.   Scientific Reports

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

(2013) Nisha S. Sipes et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells

(2013) Daniel M. Rotroff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

(2013) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rules for Identifying Potentially Reactive or Promiscuous Compounds

(2012) Robert F. Bruns et al.   JOURNAL OF MEDICINAL CHEMISTRY

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

The Use of Biochemical and Biophysical Tools for Triage of High-Throughput Screening Hits - A Case Study with Escherichia coli Phosphopantetheine Adenylyltransferase

(2010) J. Richard Miller et al.   Chemical Biology & Drug Design

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

(2010) Natasha Thorne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays

(2008) Douglas S. Auld et al.   ACS Chemical Biology