Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD)

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Use of HPLC/UPLC-spectrophotometry for detection of formazan in in vitro Reconstructed human Tissue (RhT)-based test methods employing the MTT-reduction assay to expand their applicability to strongly coloured test chemicals

(2015) N. Alépée et al.   TOXICOLOGY IN VITRO

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

(2013) Els Adriaens et al.   ARCHIVES OF TOXICOLOGY

Second-phase validation study of short time exposure test for assessment of eye irritation potency of chemicals

(2013) Hajime Kojima et al.   TOXICOLOGY IN VITRO

The importance of understanding drivers of irritation in vivo for selection of chemicals used in the development and evaluation of in vitro eye irritation assays: Cosmetics Europe analysis

(2013) J. Barroso et al.   TOXICOLOGY LETTERS

Validation study of the Short Time Exposure (STE) test to assess the eye irritation potential of chemicals

(2011) Hitoshi Sakaguchi et al.   TOXICOLOGY IN VITRO

Porcine Corneal Ocular Reversibility Assay (PorCORA) predicts ocular damage and recovery for global regulatory agency hazard categories

(2011) Michelle Piehl et al.   TOXICOLOGY IN VITRO

Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification

(2009) Yutaka Takahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Novel cultured porcine corneal irritancy assay with reversibility endpoint

(2009) Michelle Piehl et al.   TOXICOLOGY IN VITRO

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

(2009) Laurie Scott et al.   TOXICOLOGY IN VITRO

Development of the short time exposure (STE) test: An in vitro eye irritation test using SIRC cells

(2008) Yutaka Takahashi et al.   TOXICOLOGY IN VITRO