Central Role of Metabolism in Endothelial Cell Function and Vascular Disease

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase

(2017) Nuria Villalba et al.   JOURNAL OF NEUROTRAUMA

Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

(2016) Rudo F. Mapanga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Genetic defects in the hexosamine and sialic acid biosynthesis pathway

(2016) Anke P. Willems et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of fatty acid synthase is protective in pulmonary hypertension

(2016) Neetu Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway

(2016) Concepción Peiró et al.   Cardiovascular Diabetology

New insights: A role for O-GlcNAcylation in diabetic complications

(2016) Sherket B. Peterson et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

(2016) Lei Yuan et al.   Nature Communications

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma

(2015) Tao Ma et al.   ANGIOGENESIS

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

(2015) Alexander Scholz et al.   Annals of the New York Academy of Sciences

l -Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats

(2015) Paweł Bogdański et al.   BIOMEDICINE & PHARMACOTHERAPY

Endothelial Metabolism Driving Angiogenesis

(2015) Anna Rita Cantelmo et al.   CANCER JOURNAL

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

(2015) E. A. Lee et al.   CANCER RESEARCH

Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake

(2015) G. Coppiello et al.   CIRCULATION

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Glycocalyx injury in adults with nephrotic syndrome: Association with endothelial function

(2015) Francisco Thiago Santos Salmito et al.   CLINICA CHIMICA ACTA

Glutamine treatment attenuates hyperglycemia-induced mitochondrial stress and apoptosis in umbilical vein endothelial cells

(2015) SZ Safi et al.   Clinics

Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy

(2015) David J. Ramsey et al.   Current Diabetes Reports

Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition. Diabetes 2015;64:200–212

(2015) Hu Huang et al.   DIABETES

Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease

(2015) Giovanni G. Camici et al.   EUROPEAN HEART JOURNAL

Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?

(2015) P. Poredos et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels

(2015) O. Kovamees et al.   JOURNAL OF INTERNAL MEDICINE

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Angiogenesis Revisited: An Overlooked Role of Endothelial Cell Metabolism in Vessel Sprouting

(2015) Saar Vandekeere et al.   MICROCIRCULATION

Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability

(2015) Francesca Patella et al.   MOLECULAR & CELLULAR PROTEOMICS

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis

(2015) Luiza A. Rabelo et al.   Oxidative Medicine and Cellular Longevity

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

(2015) Levy A. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR PROLIFERATIVE DIABETIC RETINOPATHY

(2015) Matthew P. Simunovic et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Endothelial Surface Glycocalyx Can Regulate Flow-Induced Nitric Oxide Production in Microvessels In Vivo

(2015) Wanyi Yen et al.   PLoS One

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

(2014) Airi Jo-Watanabe et al.   AGING CELL

l-Arginine and its metabolites in kidney and cardiovascular disease

(2014) Ada Popolo et al.   AMINO ACIDS

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential

(2014) Clément d’Audigier et al.   ANGIOGENESIS

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Endothelial Cell–Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection

(2014) Lampson M. Fan et al.   CIRCULATION

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy

(2014) Rafael Simó et al.   DIABETES CARE

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

(2014) J. Goveia et al.   EMBO Molecular Medicine

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

(2014) D. O. Croci et al.   GLYCOBIOLOGY

Glycobiology of ocular angiogenesis

(2014) A. I. Markowska et al.   GLYCOBIOLOGY

Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism

(2014) Peter Stapor et al.   JOURNAL OF CELL SCIENCE

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

(2014) Hana Kolářová et al.   MEDIATORS OF INFLAMMATION

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

(2014) Tobias Deuse et al.   NATURE

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Emerging roles of post-translational modifications in signal transduction and angiogenesis

(2014) Nader Rahimi et al.   PROTEOMICS

Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity

(2013) Rajamma Mathew   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative stress in angiogenesis and vascular disease

(2013) Y.-W. Kim et al.   BLOOD

Heterogeneity of tumor endothelial cells

(2013) Kyoko Hida et al.   CANCER SCIENCE

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice

(2013) Bart JM Eskens et al.   Cardiovascular Diabetology

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

(2013) Christian Rask-Madsen et al.   Cell Metabolism

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Novel links among peroxiredoxins, endothelial dysfunction, and severity of atherosclerosis in type 2 diabetic patients with peripheral atherosclerotic disease

(2013) Eman El Eter et al.   CELL STRESS & CHAPERONES

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis

(2013) Peter Fraisl   EXPERIMENTAL CELL RESEARCH

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Glomerular Endothelial Cell Injury and Damage Precedes That of Podocytes in Adriamycin-Induced Nephropathy

(2013) Yu Bo Yang Sun et al.   PLoS One

The vascular endothelium in diabetes—a therapeutic target?

(2013) Kieren J. Mather   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Control of vessel sprouting by genetic and metabolic determinants

(2013) Guy Eelen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Unlocking the biology of RAGE in diabetic microvascular complications

(2013) Michaele B. Manigrasso et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

VEGF and Notch in Tip and Stalk Cell Selection

(2013) R. Blanco et al.   Cold Spring Harbor Perspectives in Medicine

Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction

(2013) Jochen Steppan et al.   Frontiers in Immunology

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury

(2012) Rowan F. van Golen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities

(2012) Stefany B. A. Cau et al.   Frontiers in Physiology

Vascular Aging: Facts and Factors

(2012) Ana P. Dantas et al.   Frontiers in Physiology

Mechanisms Involved in the Aging-Induced Vascular Dysfunction

(2012) Mariam El Assar et al.   Frontiers in Physiology

The Roles of Peroxidase and Phospholipase A2 Activities of Peroxiredoxin 6 in Protecting Pulmonary Microvascular Endothelial Cells Against Peroxidative Stress

(2011) Yu-Chin Lien et al.   ANTIOXIDANTS & REDOX SIGNALING

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

(2011) T Kurosu et al.   BRITISH JOURNAL OF CANCER

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

PIGF Knockout Delays Brain Vessel Growth and Maturation upon Systemic Hypoxic Challenge

(2011) Moises Freitas-Andrade et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish

(2011) S Camus et al.   ONCOGENE

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Age-related changes in endothelial function and blood flow regulation

(2011) Noboru Toda   PHARMACOLOGY & THERAPEUTICS

Placental Growth Factor Contributes to Micro-Vascular Abnormalization and Blood-Retinal Barrier Breakdown in Diabetic Retinopathy

(2011) Laura Kowalczuk et al.   PLoS One

O -GlcNAc Signaling in the Cardiovascular System

(2010) Gladys A. Ngoh et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

(2010) L. N. Broekhuizen et al.   DIABETOLOGIA

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets

(2009) P. Vizan et al.   CARCINOGENESIS

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells

(2008) Bai Luo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model

(2008) Wanfen Xiong et al.   ATHEROSCLEROSIS

Premature senescence of human endothelial cells induced by inhibition of glutaminase

(2008) Hermann Unterluggauer et al.   BIOGERONTOLOGY

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY