Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis

(2014) Hong Jiang et al.   EXPERIMENTAL NEUROLOGY

VEGF and Angiopoietins Promote Inflammatory Cell Recruitment and Mature Blood Vessel Formation in Murine Sponge/Matrigel Model

(2014) Tharsika Sinnathamby et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils

(2014) Lydia E. Haddad et al.   PLoS One

Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype

(2014) Samuel García et al.   PLoS One

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

(2014) Nicolò Rigamonti et al.   Cell Reports

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

(2013) Andrey Anisimov et al.   CIRCULATION

Angiopoietin signaling in the vasculature

(2013) Lauri Eklund et al.   EXPERIMENTAL CELL RESEARCH

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages

(2013) Seung Hyeok Seok et al.   MOLECULES AND CELLS

Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis

(2013) Young-Sool Hah et al.   ARTHRITIS RESEARCH & THERAPY

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

(2012) Karl H. Plate et al.   ACTA NEUROPATHOLOGICA

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis

(2012) Sarah Krausz et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

(2012) Jae Hong Im et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor associated macrophages and neutrophils in tumor progression

(2012) Maria R. Galdiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

(2012) Palanisamy Kanakaraj et al.   mAbs

Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury

(2012) Neng F. Kurniati et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiopoietin-2 promotes myeloid cell infiltration in a  2-integrin-dependent manner

(2011) A. Scholz et al.   BLOOD

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

(2011) H. Huang et al.   CLINICAL CANCER RESEARCH

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

(2011) Seth B. Coffelt et al.   JOURNAL OF IMMUNOLOGY

Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors

(2010) Seth B. Coffelt et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation

(2010) Jonas Fuxe et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease

(2010) Konstantinos A. Oikonomou et al.   INFLAMMATORY BOWEL DISEASES

Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease

(2010) J. Westra et al.   RHEUMATOLOGY

Angiopoietin-2 in experimental colitis

(2009) Vijay C. Ganta et al.   INFLAMMATORY BOWEL DISEASES

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of angiopoietin expression by bacterial lipopolysaccharide

(2008) Mahroo Mofarrahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohnʼs disease patients

(2007) Inés D. Pousa et al.   INFLAMMATORY BOWEL DISEASES