Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner

(2015) Michael B. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression

(2015) Xiang Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis

(2015) Marie-Claude Durpès et al.   CARDIOVASCULAR RESEARCH

Removal of Abnormal MyofilamentO-GlcNAcylation Restores Ca2+Sensitivity in Diabetic Cardiac Muscle

(2015) Genaro A. Ramirez-Correa et al.   DIABETES

The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes

(2015) Martin Heier et al.   Diabetes & Vascular Disease Research

Decreased levels of soluble receptor for advanced glycation end-products in aortic valve calcification patients

(2015) H. Zheng et al.   GENETICS AND MOLECULAR RESEARCH

sRAGE, inflammation, and risk of atrial fibrillation: results from the Atherosclerosis Risk in Communities (ARIC) Study

(2015) Mahmoud Al Rifai et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

AKAP150 mobilizes cPKC-dependent cardiac glucotoxicity

(2014) Chao Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

(2014) Mark W. Sims et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Advanced Glycation End Products Promote Heart Failure Through Inducing the Immune Maturation of Dendritic Cells

(2014) Weiwei Cao et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Circulating Soluble Receptor for Advanced Glycation End Product Identifies Patients With Bicuspid Aortic Valve and Associated Aortopathies

(2014) Emanuela Branchetti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

(2014) Anna M.D. Watson et al.   ATHEROSCLEROSIS

The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta

(2014) Jamie Imbriolo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction

(2014) Jueun Hong et al.   BIOMATERIALS

Effects of Advanced Glycation End Products on Calcium Handling in Cardiomyocytes

(2014) Dewen Yan et al.   CARDIOLOGY

ROS signalling between endothelial cells and cardiac cells

(2014) M. Zhang et al.   CARDIOVASCULAR RESEARCH

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function

(2014) Masato Kajikawa et al.   DIABETES CARE

Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via ProteinO-GlcNAcylation

(2014) Davide Vigetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The detrimental effects of acute hyperglycemia on myocardial glucose uptake

(2014) Danzil Joseph et al.   LIFE SCIENCES

Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs

(2014) Arumugam Parthasarathy et al.   LIFE SCIENCES

Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein

(2014) Ting Zhang et al.   MOLECULAR BIOLOGY REPORTS

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G+ -Toxins

(2014) Feng Chen et al.   PLoS One

Receptor for Advanced Glycation End Products - Membrane Type1 Matrix Metalloproteinase Axis Regulates Tissue Factor Expression via RhoA and Rac1 Activation in High-Mobility Group Box-1 Stimulated Endothelial Cells

(2014) Koichi Sugimoto et al.   PLoS One

Detrimental effects of acute hyperglycaemia on the rat heart

(2013) R. F. Mapanga et al.   Acta Physiologica

PKCβ Promotes Vascular Inflammation and Acceleration of Atherosclerosis in Diabetic ApoE Null Mice

(2013) Linghua Kong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes

(2013) Kelly J. Hunt et al.   ATHEROSCLEROSIS

Relationship between Advanced Glycation End Products and Plaque Progression in Patients with Acute Coronary Syndrome: The JAPAN-ACS Sub-study

(2013) Yoshifumi Fukushima et al.   Cardiovascular Diabetology

Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification

(2013) Marcelle GA van Eupen et al.   Cardiovascular Diabetology

Advanced glycation end-products impair Na+/K+-ATPase activity in diabetic cardiomyopathy: Role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway

(2013) Qiong Yuan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Hyperglycemia-Induced Protein Kinase C  2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

(2013) S. Lei et al.   DIABETES

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

(2013) M. G. A. van Eupen et al.   DIABETOLOGIA

Plasma sRAGE and N-(carboxymethyl) lysine in patients with CHF and/or COPD

(2013) Piera Boschetto et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats

(2013) Kathryn J. Wright et al.   EXPERIMENTAL GERONTOLOGY

Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

(2013) Thorsten M. Leucker et al.   PLoS One

Skin Autofluorescence, a Non-Invasive Marker for AGE Accumulation, Is Associated with the Degree of Atherosclerosis

(2013) Martijn A. M. den Dekker et al.   PLoS One

Glyco-oxidation and cardiovascular complications in type 2 diabetes: a clinical update

(2012) Francesco Piarulli et al.   ACTA DIABETOLOGICA

The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury

(2012) Yi Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets

(2012) Peter A. Hecker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy

(2012) Eduardo S. Fricovsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

(2012) Sergio Raposeiras-Roubín et al.   Cardiovascular Diabetology

Inhibition of Protein Kinase C β Ameliorates Impaired Angiogenesis in Type I Diabetic Mice Complicating Myocardial Infarction

(2012) Akihiko Ikeda et al.   CIRCULATION JOURNAL

Increased DNA-Glycation in Type 2 Diabetic Patients: The Effect of Thiamine and Pyridoxine Therapy

(2012) F. Polizzi et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

(2012) Alba Naudi et al.   Experimental Diabetes Research

Exploring LeukocyteO-GlcNAcylation as a Novel Diagnostic Tool for the Earlier Detection of Type 2 Diabetes Mellitus

(2012) Clare Springhorn et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia

(2012) Ni-Huiping Son et al.   PLoS One

Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction

(2012) Rudo F. Mapanga et al.   PLoS One

Role of oxidative stress in diabetes-mediated vascular dysfunction: Unifying hypothesis of diabetes revisited

(2012) Stephen W. Schaffer et al.   VASCULAR PHARMACOLOGY

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

(2012) Wai Ho Tang et al.   Frontiers in Pharmacology

Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling

(2012) Allyson L. Kranstuber et al.   Frontiers in Physiology

The hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance

(2011) U. Rajamani et al.   Acta Physiologica

Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic Apolipoprotein E−/− Mice

(2011) Srinivasan Vedantham et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

(2011) Katalin Módis et al.   BIOCHEMICAL PHARMACOLOGY

NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1

(2011) Magali Balteau et al.   CARDIOVASCULAR RESEARCH

Association of soluble receptor for advanced glycation end-product with increasing central aortic stiffness in hypertensive patients

(2011) Se-Jung Yoon et al.   CORONARY ARTERY DISEASE

Total Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products as Predictive Biomarkers of Coronary Heart Disease Risk in Patients With Type 2 Diabetes: An Analysis From the CARDS Trial

(2011) H. M. Colhoun et al.   DIABETES

Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans

(2011) Terje Lund et al.   Diabetes & Vascular Disease Research

Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy

(2011) N. Rabbani et al.   DIABETES OBESITY & METABOLISM

Muscle Creatine Kinase Deficiency Triggers Both Actin Depolymerization and Desmin Disorganization by Advanced Glycation End Products in Dilated Cardiomyopathy

(2011) Nicolas Diguet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating soluble receptor for advanced glycation end product (sRAGE) and left ventricular hypertrophy in patients with chronic kidney disease (CKD)

(2011) D. Leonardis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Tribulosin protects rat hearts from ischemia/reperfusion injury

(2010) Shuang Zhang et al.   ACTA PHARMACOLOGICA SINICA

Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress

(2010) Wai Ho Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosis

(2010) Uthra Rajamani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity

(2010) Xiao-Liang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative stress: a key contributor to diabetic cardiomyopathyThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Madhu Khullar et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

(2010) N. Rabbani et al.   DIABETES

Glycated albumin, a precursor of advanced glycation end-products, up-regulates NADPH oxidase and enhances oxidative stress in human endothelial cells: molecular correlate of diabetic vasculopathy

(2010) Bruno K. Rodiño-Janeiro et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Aldose Reductase Regulates Vascular Smooth Muscle Cell Proliferation by Modulating G1/S Phase Transition of Cell Cycle

(2010) Ravinder Tammali et al.   ENDOCRINOLOGY

A PKC-β inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats

(2010) Liping Wei et al.   MICROVASCULAR RESEARCH

O-linked β-N-acetylglucosamine During Hyperglycemia Exerts Both Anti-Inflammatory and Pro-Oxidative Properties in the Endothelial System

(2010) Angana Gupta Rajapakse et al.   Oxidative Medicine and Cellular Longevity

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells

(2009) Andrew T Sage et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A PKC-β inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats

(2009) Liping Wei et al.   APOPTOSIS

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia

(2009) Cormac T. Taylor et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxisome proliferator-activated receptor-γ activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor

(2009) Sang-Hyun Ihm et al.   BASIC RESEARCH IN CARDIOLOGY

Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose

(2009) Laura Toma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural analyses of enzymes involved in the O-GlcNAc modification

(2009) Carlos Martinez-Fleites et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of protein O-linked β-N-acetylglucosamine in mediating cardiac stress responses

(2009) John C. Chatham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen

(2009) Kuo-Chu Chang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ischaemic preconditioning improves proteasomal activity and increases the degradation of  PKC during reperfusion

(2009) E. N. Churchill et al.   CARDIOVASCULAR RESEARCH

Protein Kinase Cα, but Not PKCβ or PKCγ, Regulates Contractility and Heart Failure Susceptibility

(2009) Qinghang Liu et al.   CIRCULATION RESEARCH

S100B Interaction With the Receptor for Advanced Glycation End Products (RAGE)

(2009) J.N. Tsoporis et al.   CIRCULATION RESEARCH

Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

(2009) Kim A. Connelly et al.   Circulation-Heart Failure

Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice

(2009) Jan M. Nielsen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Hyperglycemia Regulates RUNX2 Activation and Cellular Wound Healing through the Aldose Reductase Polyol Pathway

(2009) David R. D'Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase signaling and cardiac myocyte function

(2009) Ashwin Akki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults

(2009) Richard D. Semba et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells

(2009) Santosh Kumar et al.   LIFE SCIENCES

Therapeutic targets to reduce cardiovascular disease in type 2 diabetes

(2009) Cyrus DeSouza et al.   NATURE REVIEWS DRUG DISCOVERY

Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Is Associated With Increased Aortic Pulse Wave Velocity in Adults

(2008) R. D. Semba et al.   AMERICAN JOURNAL OF HYPERTENSION

Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options

(2008) Ashish Aneja et al.   AMERICAN JOURNAL OF MEDICINE

Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice

(2008) Anna J. Bowes et al.   AMERICAN JOURNAL OF PATHOLOGY

Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore

(2008) Radha Ananthakrishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis

(2008) Christian A. Gleissner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis

(2008) Conrad P. Hodgkinson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones

(2008) Oya Bozdağ-Dündar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective PKC Beta Inhibition with Ruboxistaurin and Endothelial Function in Type-2 Diabetes Mellitus

(2008) Nehal N. Mehta et al.   CARDIOVASCULAR DRUGS AND THERAPY

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

(2008) L. G. Bucciarelli et al.   DIABETES

The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammation

(2008) A. C. Calkin et al.   DIABETOLOGIA

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox

(2008) Houssam Raad et al.   FASEB JOURNAL

Mice deficient in PKCβ and apolipoprotein E display decreased atherosclerosis

(2008) Evis Harja et al.   FASEB JOURNAL

Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action

(2008) Carolina D. Garciarena et al.   JOURNAL OF APPLIED PHYSIOLOGY

AGEs-RAGE System Mediates Atrial Structural Remodeling in the Diabetic Rat

(2008) TAKESHI KATO et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy

(2008) Heng Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR

The discovery of nitric oxide and its role in vascular biology

(2006) S Moncada et al.   BRITISH JOURNAL OF PHARMACOLOGY