Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

(2017) Di Zhao et al.   NATURE

Cdc20: At the Crossroads between Chromosome Segregation and Mitotic Exit

(2017) Maria Kapanidou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment

(2016) Lubing Gu et al.   CANCER CELL

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

(2016) Zachary Steinhart et al.   NATURE MEDICINE

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

(2016) J Tong et al.   ONCOGENE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Radiosensitization of Human Colorectal Cancer Cells by MLN4924

(2016) Juefeng Wan et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

RNF4-Dependent Oncogene Activation by Protein Stabilization

(2016) Jane J. Thomas et al.   Cell Reports

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

(2016) Ohad Tarcic et al.   Cell Reports

Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

(2016) Genevieve L. Coe et al.   Scientific Reports

Role of the focal adhesion protein TRIM15 in colon cancer development

(2015) Ok-Hee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

(2015) Young Joo Jeon et al.   CANCER CELL

c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4

(2015) Román González-Prieto et al.   CELL CYCLE

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

RING finger protein 31 promotes p53 degradation in breast cancer cells

(2015) J Zhu et al.   ONCOGENE

Porcupine inhibitor suppresses paracrine Wnt-driven growth ofRnf43;Znrf3-mutant neoplasia

(2015) Bon-Kyoung Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development

(2015) Mei-Yu Piao et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Genetics of the Serrated Pathway to Colorectal Cancer

(2015) Dmitriy Kedrin et al.   Clinical and Translational Gastroenterology

KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation

(2015) Shirish Shukla et al.   NEOPLASIA

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

(2014) Amy V Paschall et al.   BMC CANCER

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study

(2014) Xing Wei Wang et al.   Gut and Liver

Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma

(2014) HAIJIN CHEN et al.   Molecular Medicine Reports

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

(2014) Katharine L. Sackton et al.   NATURE

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impact of the Mdm2 SNP309-G allele on a murine model of colorectal cancer

(2014) X Zhang et al.   ONCOGENE

Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

(2014) Alexander Ring et al.   Stem Cell Reviews and Reports

XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

(2014) M Ehrenschwender et al.   Cell Death & Disease

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers

(2013) A I Phipps et al.   BRITISH JOURNAL OF CANCER

TRAF6 Upregulates Expression of HIF-1  and Promotes Tumor Angiogenesis

(2013) H. Sun et al.   CANCER RESEARCH

Expression of Survivin and Cortactin in Colorectal Adenocarcinoma: Association with Clinicopathological Parameters

(2013) Ying-Yu Lee et al.   DISEASE MARKERS

A RING finger to wed TCF and β-catenin

(2013) Claudio Cantù et al.   EMBO REPORTS

Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival

(2013) Beibei Wu et al.   EMBO REPORTS

Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

(2013) Hayley Davis et al.   GUT

CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer

(2013) Wen-jing Wu et al.   Journal of Translational Medicine

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Biology: A New RING to Wnt Signaling

(2012) Eric R. Fearon et al.   CURRENT BIOLOGY

Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20

(2012) Michel V Hadjihannas et al.   EMBO REPORTS

1039 A High Throughput Screening Platform for the Identification of Small Molecule Inhibitors of the E3 Ligase E6AP

(2012) I. Street et al.   EUROPEAN JOURNAL OF CANCER

Tumor suppressor functions of FBW7 in cancer development and progression

(2012) Zhiwei Wang et al.   FEBS LETTERS

Poly-Small Ubiquitin-like Modifier (PolySUMO)-binding Proteins Identified through a String Search

(2012) Huaiyu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

(2012) J. E. Grim et al.   MOLECULAR AND CELLULAR BIOLOGY

XIAP Monoubiquitylates Groucho/TLE to Promote Canonical Wnt Signaling

(2012) Alison J. Hanson et al.   MOLECULAR CELL

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

(2012) Rachael Baker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

Expression of the Antiapoptotic Protein Survivin in Colon Cancer

(2011) Jonathan M. Hernandez et al.   Clinical Colorectal Cancer

Cytokines, Inflammation and Colon Cancer

(2011) L. Klampfer   CURRENT CANCER DRUG TARGETS

Epigenetics and colorectal cancer

(2011) Victoria Valinluck Lao et al.   Nature Reviews Gastroenterology & Hepatology

The spatial and temporal organization of ubiquitin networks

(2011) Caroline Grabbe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

(2011) A. T. Sasaki et al.   Science Signaling

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model

(2010) Wen-Bin Tsai et al.   PLoS One

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination

(2009) Kexin Xu et al.   CANCER CELL

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Somatic Mutations of the CDC4 (FBXW7) Gene in Hereditary Colorectal Tumors

(2009) Michiko Miyaki et al.   ONCOLOGY

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis

(2008) Takeo Fujita et al.   AMERICAN JOURNAL OF PATHOLOGY

Bortezomib (Velcade) Induces p27Kip1 Expression through S-Phase Kinase Protein 2 Degradation in Colorectal Cancer

(2008) S. Uddin et al.   CANCER RESEARCH

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

Bortezomib With or Without Irinotecan in Relapsed or Refractory Colorectal Cancer: Results From a Randomized Phase II Study

(2008) Peter S. Kozuch et al.   JOURNAL OF CLINICAL ONCOLOGY

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY