Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

(2012) Simon J Leedham et al.   GUT

CDC4/FBXW7 and the ‘just enough’ model of tumourigenesis

(2012) Hayley Davis et al.   JOURNAL OF PATHOLOGY

Role of the ubiquitin ligase Fbw7 in cancer progression

(2011) Yabin Cheng et al.   CANCER AND METASTASIS REVIEWS

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

(2011) Hayley Davis et al.   JOURNAL OF PATHOLOGY

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

(2010) Annabelle Lewis et al.   GUT

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

(2010) Mandayam O Nandan et al.   Molecular Cancer

Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation

(2010) M T Bengoechea-Alonso et al.   ONCOGENE

Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine

(2009) B. B. McConnell et al.   CANCER RESEARCH

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

(2009) Patrick Pollard et al.   GASTROENTEROLOGY

Somatic Mutations of the CDC4 (FBXW7) Gene in Hereditary Colorectal Tumors

(2009) Michiko Miyaki et al.   ONCOLOGY

The Fbxw7/hCdc4 tumor suppressor in human cancer

(2008) YingMeei Tan et al.   CANCER LETTERS

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE