Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

(2013) Garry G Sedgwick et al.   EMBO JOURNAL

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

(2012) Nevena V. Dimova et al.   NATURE CELL BIOLOGY

An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

(2012) Xing Zeng et al.   Nature Chemical Biology

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

(2012) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit

(2010) Wouter van Zon et al.   JOURNAL OF CELL BIOLOGY

How cyclin A destruction escapes the spindle assembly checkpoint

(2010) Barbara Di Fiore et al.   JOURNAL OF CELL BIOLOGY

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

(2010) Paula C. A. da Fonseca et al.   NATURE

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

(2010) Bettina A Buschhorn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Analysis of Activator-Binding Sites on the APC/C Supports a Cooperative Substrate-Binding Mechanism

(2009) Mary E. Matyskiela et al.   MOLECULAR CELL

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL