Medicine is not health care, food is health care: plant metabolic engineering, diet and human health

Cardiovascular Protective Effects and Clinical Applications of Resveratrol

(2017) Sanghyun Cho et al.   JOURNAL OF MEDICINAL FOOD

Improving nutrition through biofortification: A review of evidence from HarvestPlus, 2003 through 2016

(2017) Howarth E. Bouis et al.   Global Food Security-Agriculture Policy Economics and Environment

Provitamin A Carotenoid–Biofortified Maize Consumption Increases Pupillary Responsiveness among Zambian Children in a Randomized Controlled Trial

(2016) Amanda C Palmer et al.   JOURNAL OF NUTRITION

Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

(2016) Federica Rizzi et al.   Journal of Translational Medicine

Genetic enhancement of oil content in potato tuber (Solanum tuberosumL.) through an integrated metabolic engineering strategy

(2016) Qing Liu et al.   PLANT BIOTECHNOLOGY JOURNAL

Identification of Homogentisate Dioxygenase as a Target for Vitamin E Biofortification in Oilseeds

(2016) Minviluz G. Stacey et al.   PLANT PHYSIOLOGY

Elevated vitamin E content improves all-transβ-carotene accumulation and stability in biofortified sorghum

(2016) Ping Che et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

(2016) Joshua R Widhalm et al.   Horticulture Research

Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial

(2015) Elise F Talsma et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

(2015) Dieter Blancquaert et al.   NATURE BIOTECHNOLOGY

An Upstream Open Reading Frame Is Essential for Feedback Regulation of Ascorbate Biosynthesis in Arabidopsis

(2015) William A. Laing et al.   PLANT CELL

Ectopic expression of snapdragon transcription factors facilitates the identification of genes encoding enzymes of anthocyanin decoration in tomato

(2015) Takayuki Tohge et al.   PLANT JOURNAL

Manipulation of the Rice L-Galactose Pathway: Evaluation of the Effects of Transgene Overexpression on Ascorbate Accumulation and Abiotic Stress Tolerance

(2015) Gui-Yun Zhang et al.   PLoS One

Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato

(2015) Yang Zhang et al.   Nature Communications

Promoting consumption of fruit and vegetables for better health. Have campaigns delivered on the goals?

(2014) Reetica Rekhy et al.   APPETITE

Achieving optimal n–3 fatty acid status: the vegetarian’s challenge... or not

(2014) William S Harris   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

(2014) Kathryn E Bradbury et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial

(2014) Bryan Gannon et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Transcriptional regulation of fatty acid production in higher plants: Molecular bases and biotechnological outcomes

(2014) Chloé Marchive et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Evaluation of the Effects ofVaccinium arctostaphylosL. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2014) Rasool Soltani et al.   Evidence-based Complementary and Alternative Medicine

Freeze-Dried Strawberries Lower Serum Cholesterol and Lipid Peroxidation in Adults with Abdominal Adiposity and Elevated Serum Lipids

(2014) Arpita Basu et al.   JOURNAL OF NUTRITION

Tocopherol and tocotrienol contents of different varieties of rice in Malaysia

(2014) Balakrishnan Shammugasamy et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Development and study of a maize cultivar rich in anthocyanins: coloured polenta, a new functional food

(2014) Chiara Lago et al.   PLANT BREEDING

Anthocyanins in corn: a wealth of genes for human health

(2014) Katia Petroni et al.   PLANTA

Metabolic Engineering Camelina sativa with Fish Oil-Like Levels of DHA

(2014) James R. Petrie et al.   PLoS One

Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies

(2014) X. Wang et al.   BMJ-British Medical Journal

Plants, Diet, and Health

(2013) Cathie Martin et al.   Annual Review of Plant Biology

Carotenoids are more bioavailable from papaya than from tomato and carrot in humans: a randomised cross-over study

(2013) Ralf M. Schweiggert et al.   BRITISH JOURNAL OF NUTRITION

High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

(2013) Aedín Cassidy et al.   CIRCULATION

The Case for Anthocyanin Consumption to Promote Human Health: A Review

(2013) Elisa Pojer et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Synergistic effect of WRI1 and DGAT1 coexpression on triacylglycerol biosynthesis in plants

(2013) Thomas Vanhercke et al.   FEBS LETTERS

Dietary Bioactive Compounds and Their Health Implications

(2013) Rui Hai Liu   JOURNAL OF FOOD SCIENCE

Dietary Flavonoids from Modified Apple Reduce Inflammation Markers and Modulate Gut Microbiota in Mice

(2013) Richard V. Espley et al.   JOURNAL OF NUTRITION

Intakes of Anthocyanins and Flavones Are Associated with Biomarkers of Insulin Resistance and Inflammation in Women

(2013) Amy Jennings et al.   JOURNAL OF NUTRITION

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans

(2013) José M. Alvarez-Suarez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: Iterative metabolic engineering for the synthesis of n−3 LC-PUFAs in transgenic plants

(2013) Noemi Ruiz-Lopez et al.   METABOLIC ENGINEERING

Metabolic engineering of biomass for high energy density: oilseed-like triacylglycerol yields from plant leaves

(2013) Thomas Vanhercke et al.   PLANT BIOTECHNOLOGY JOURNAL

Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop

(2013) Noemi Ruiz-Lopez et al.   PLANT JOURNAL

Construction of transplastomic lettuce (Lactuca sativa) dominantly producing astaxanthin fatty acid esters and detailed chemical analysis of generated carotenoids

(2013) Hisashi Harada et al.   TRANSGENIC RESEARCH

Health-Promoting Components of Fruits and Vegetables in the Diet

(2013) Rui Hai Liu   Advances in Nutrition

β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children

(2012) Guangwen Tang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids

(2012) Michel de Lorgeril et al.   BMC Medicine

Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota

(2012) Audrey M. Neyrinck et al.   BRITISH JOURNAL OF NUTRITION

The interface between plant metabolic engineering and human health

(2012) Cathie Martin   CURRENT OPINION IN BIOTECHNOLOGY

Introduction of β-Carotene–Rich Orange Sweet Potato in Rural Uganda Resulted in Increased Vitamin A Intakes among Children and Women and Improved Vitamin A Status among Children

(2012) Christine Hotz et al.   JOURNAL OF NUTRITION

Study and characterization of a novel functional food: purple popcorn

(2012) Chiara Lago et al.   MOLECULAR BREEDING

The modification of plant oil composition via metabolic engineering-better nutrition by design

(2012) Richard P. Haslam et al.   PLANT BIOTECHNOLOGY JOURNAL

Suppression of theSUGAR-DEPENDENT1triacylglycerol lipase family during seed development enhances oil yield in oilseed rape (Brassica napusL.)

(2012) Amélie A. Kelly et al.   PLANT BIOTECHNOLOGY JOURNAL

WRINKLED Transcription Factors Orchestrate Tissue-Specific Regulation of Fatty Acid Biosynthesis in Arabidopsis

(2012) A. To et al.   PLANT CELL

Ectopic overexpression of peach GDP-d-mannose pyrophosphorylase and GDP-d-mannose-3′,5′-epimerase in transgenic tobacco

(2012) Tsuyoshi Imai et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Genetic and biochemical basis for alternative routes of tocotrienol biosynthesis for enhanced vitamin E antioxidant production

(2012) Chunyu Zhang et al.   PLANT JOURNAL

Metabolic Engineering Plant Seeds with Fish Oil-Like Levels of DHA

(2012) James R. Petrie et al.   PLoS One

The Significance of Different Diacylgycerol Synthesis Pathways on Plant Oil Composition and Bioengineering

(2012) Philip D. Bates et al.   Frontiers in Plant Science

The BioCassava Plus Program: Biofortification of Cassava for Sub-Saharan Africa

(2011) Richard Sayre et al.   Annual Review of Plant Biology

16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010

(2011) D M Parkin et al.   BRITISH JOURNAL OF CANCER

A large-scale intervention to introduce orange sweet potato in rural Mozambique increases vitamin A intakes among children and women

(2011) Christine Hotz et al.   BRITISH JOURNAL OF NUTRITION

Translocation and the alternative D-galacturonate pathway contribute to increasing the ascorbate level in ripening tomato fruits together with the D-mannose/L-galactose pathway

(2011) Adebanjo Ayobamidele Badejo et al.   JOURNAL OF EXPERIMENTAL BOTANY

Oxidation of Crude Corn Oil with and without Elevated Tocotrienols

(2011) David Dolde et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

The Or Gene Enhances Carotenoid Accumulation and Stability During Post-Harvest Storage of Potato Tubers

(2011) Li Li et al.   Molecular Plant

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

(2011) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of Δ6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants

(2011) Olga Sayanova et al.   PLANT BIOTECHNOLOGY JOURNAL

Enhancing ascorbate in fruits and tubers through over-expression of the l-galactose pathway gene GDP-l-galactose phosphorylase

(2011) Sean Bulley et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant Science and Human Nutrition: Challenges in Assessing Health-Promoting Properties of Phytochemicals

(2011) M. H. Traka et al.   PLANT CELL

How Can Research on Plants Contribute to Promoting Human Health?

(2011) Cathie Martin et al.   PLANT CELL

Enhanced levels of vitamin B6 increase aerial organ size and positively affect stress tolerance in Arabidopsis

(2011) Maja Raschke et al.   PLANT JOURNAL

Combined transcriptome, genetic diversity and metabolite profiling in tomato fruit reveals that the ethylene response factor SlERF6 plays an important role in ripening and carotenoid accumulation

(2011) Je Min Lee et al.   PLANT JOURNAL

Duplicate Maize Wrinkled1 Transcription Factors Activate Target Genes Involved in Seed Oil Biosynthesis

(2011) B. Pouvreau et al.   PLANT PHYSIOLOGY

Over-expression of a grape stilbene synthase gene in tomato induces parthenocarpy and causes abnormal pollen development

(2011) Ilaria Ingrosso et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Transgenic oilseed crops as an alternative to fish oils

(2011) Olga Sayanova et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary intake of stearidonic acid–enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety

(2010) Shawna L Lemke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The regulation of carotenoid pigmentation in flowers

(2010) Changfu Zhu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of Vascular Endothelial Function by Procyanidin-Rich Foods and Beverages†

(2010) Paul W. Caton et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Flavonoids Increase Plasma Very Long-Chain (n-3) Fatty Acids in Rats

(2010) Marie-Claire Toufektsian et al.   JOURNAL OF NUTRITION

Effects of resveratrol and other wine polyphenols on vascular function: an update

(2010) Paolo Gresele et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fruits, Vegetables, and Cancer Prevention: Turmoil in the Produce Section

(2010) Walter C. Willett   JNCI-Journal of the National Cancer Institute

Rare genetic variation at Zea mays crtRB1 increases β-carotene in maize grain

(2010) Jianbing Yan et al.   NATURE GENETICS

Chromoplast Differentiation: Current Status and Perspectives

(2010) I. Egea et al.   PLANT AND CELL PHYSIOLOGY

Provitamin A Accumulation in Cassava (Manihot esculenta) Roots Driven by a Single Nucleotide Polymorphism in a Phytoene Synthase Gene

(2010) Ralf Welsch et al.   PLANT CELL

PII is induced by WRINKLED1 and fine-tunes fatty acid composition in seeds of Arabidopsis thaliana

(2010) Sébastien Baud et al.   PLANT JOURNAL

Expression of ZmLEC1 and ZmWRI1 Increases Seed Oil Production in Maize

(2010) B. Shen et al.   PLANT PHYSIOLOGY

A horizontal gene transfer at the origin of phenylpropanoid metabolism: a key adaptation of plants to land

(2009) Giovanni Emiliani et al.   Biology Direct

Blood orange juice inhibits fat accumulation in mice

(2009) L Titta et al.   INTERNATIONAL JOURNAL OF OBESITY

Food Addiction

(2009) Ashley N. Gearhardt et al.   Journal of Addiction Medicine

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of ‘heart-healthy’ omega-3 fatty acids

(2009) Noemí Ruiz-López et al.   PLANT BIOTECHNOLOGY JOURNAL

An AP2-type transcription factor, WRINKLED1, ofArabidopsis thalianabinds to the AW-box sequence conserved among proximal upstream regions of genes involved in fatty acid synthesis

(2009) Kenichiro Maeo et al.   PLANT JOURNAL

Towards the production of high levels of eicosapentaenoic acid in transgenic plants: the effects of different host species, genes and promoters

(2009) Bifang Cheng et al.   TRANSGENIC RESEARCH

PII in higher plants: a modern role for an ancient protein

(2009) R. Glen Uhrig et al.   TRENDS IN PLANT SCIENCE

Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches

(2008) Paul D. Fraser et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanisms of combined action of different chemopreventive dietary compounds

(2008) Theo M. de Kok et al.   EUROPEAN JOURNAL OF NUTRITION

Accumulation of Isoflavone Genistin in Transgenic Tomato Plants Overexpressing a Soybean Isoflavone Synthase Gene

(2008) Chun-Hat Shih et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Whole Berries versus Berry Anthocyanins: Interactions with Dietary Fat Levels in the C57BL/6J Mouse Model of Obesity

(2008) Ronald L. Prior et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Scurvy Is Still Present in Developed Countries

(2008) Bertha Velandia et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Stearidonic Acid-Enriched Soybean Oil Increased the Omega-3 Index, an Emerging Cardiovascular Risk Marker

(2008) William S. Harris et al.   LIPIDS

Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans

(2008) Giuseppe Maiani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors

(2008) Eugenio Butelli et al.   NATURE BIOTECHNOLOGY

Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering

(2008) Tomohisa Hasunuma et al.   PLANT JOURNAL

AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: expression in fruit results in very high levels of both types of polyphenol

(2008) Jie Luo et al.   PLANT JOURNAL

Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification

(2008) C. E. Harjes et al.   SCIENCE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL