Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants

Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives

(2016) Charles O. Ogindo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots

(2016) Rongjun Fang et al.   BMC PLANT BIOLOGY

Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase

(2016) Samantha Mostert et al.   Chemical Biology & Drug Design

S-Glutathionylation of Keap1: a new role for glutathioneS-transferase pi in neuronal protection

(2016) Andreia Neves Carvalho et al.   FEBS LETTERS

Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans

(2016) Sweatha V. Nair et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Identification and localization of bioactive naphthoquinones in the roots and rhizosphere of Paterson’s curse (Echium plantagineum), a noxious invader

(2016) Xiaocheng Zhu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Transgenic analysis reveals LeACS-1 as a positive regulator of ethylene-induced shikonin biosynthesis in Lithospermum erythrorhizon hairy roots

(2016) Rongjun Fang et al.   PLANT MOLECULAR BIOLOGY

Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells

(2016) Anna Kawiak et al.   PLoS One

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

(2016) A. Rialdi et al.   SCIENCE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Microbiome and Biocatalytic Bacteria in Monkey Cup (Nepenthes Pitcher) Digestive Fluid

(2016) Xin-Yue Chan et al.   Scientific Reports

Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants

(2016) Kanade Tatsumi et al.   Frontiers in Plant Science

Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants

(2016) Julien Le Roy et al.   Frontiers in Plant Science

Pollinator-prey conflicts in carnivorous plants: When flower and trap properties mean life or death

(2016) Ashraf M. El-Sayed et al.   Scientific Reports

Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach

(2016) Ang Chen et al.   Scientific Reports

5- O -Acyl plumbagins inhibit DNA polymerase activity and suppress the inflammatory response

(2015) Takefumi Onodera et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats

(2015) Xiaohui Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of LeMYB1 enhances shikonin formation by up-regulating key shikonin biosynthesis-related genes in Lithospermum erythrorhizon

(2015) H. Zhao et al.   BIOLOGIA PLANTARUM

Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro

(2015) Takashi Hashimoto et al.   CHINESE MEDICAL JOURNAL

Juglone induces cell death of Acanthamoeba through increased production of reactive oxygen species

(2015) Bijay Kumar Jha et al.   EXPERIMENTAL PARASITOLOGY

Lawsonia inermis L. – A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review

(2015) Dhananjay Kumar Singh et al.   INDUSTRIAL CROPS AND PRODUCTS

A Familiar Ring to It: Biosynthesis of Plant Benzoic Acids

(2015) Joshua R. Widhalm et al.   Molecular Plant

Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines

(2015) Shao-Hung Wang et al.   MOLECULES

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells

(2015) Aik Kia Khaw et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products

(2015) Darcy J. Atkinson et al.   NATURAL PRODUCT REPORTS

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

(2015) Mark D. White et al.   NATURE

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition

(2015) Karl A. P. Payne et al.   NATURE

Proteomics Analyses ofBacillus subtilisafter Treatment with Plumbagin, a Plant-Derived Naphthoquinone

(2015) Panga Jaipal Reddy et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1in Synechocystisand Arabidopsis

(2015) Abdelhak Fatihi et al.   PLANT CELL

In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes

(2015) Wiriyaporn Sumsakul et al.   Asian Pacific Journal of Tropical Medicine

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

(2015) Ravi Thakur et al.   Scientific Reports

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Review of the Chemistry and Pharmacology of 7-Methyljugulone

(2014) Armelle T Mbaveng et al.   African Health Sciences

1,4-Naphthoquinone, a pro-oxidant, suppresses immune responses via KEAP-1 glutathionylation

(2014) Lokesh Gambhir et al.   BIOCHEMICAL PHARMACOLOGY

Biosynthesis and physiology of coenzyme Q in bacteria

(2014) Laurent Aussel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines

(2014) Navneet Kishore et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Shikonin Derivatives Targeting Tubulin as Anticancer Agents

(2014) Jing Guo et al.   Chemical Biology & Drug Design

Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells

(2014) Xiaoyu Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathways

(2014) Ying Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway

(2014) Yuanyuan Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibitory Potential of Naphthoquinones Leached from Leaves and Exuded from Roots of the Invasive Plant Impatiens glandulifera

(2014) Regina Ruckli et al.   JOURNAL OF CHEMICAL ECOLOGY

Lawsonia inermis L. (henna): Ethnobotanical, phytochemical and pharmacological aspects

(2014) Ruchi Badoni Semwal et al.   JOURNAL OF ETHNOPHARMACOLOGY

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

(2014) Lars-Oliver Klotz et al.   MOLECULES

The Origin and Biosynthesis of the Benzenoid Moiety of Ubiquinone (Coenzyme Q) in Arabidopsis

(2014) A. Block et al.   PLANT CELL

Phytotoxic action of naphthoquinone juglone demonstrated on lettuce seedling roots

(2014) Petr Babula et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Arbuscular mycorrhizal fungal hyphae enhance transport of the allelochemical juglone in the field

(2014) Michaela Achatz et al.   SOIL BIOLOGY & BIOCHEMISTRY

Priming crops against biotic and abiotic stresses: MSB as a tool for studying mechanisms

(2014) Andrés A. Borges et al.   Frontiers in Plant Science

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism

(2014) Scott C. Farrow et al.   Frontiers in Plant Science

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Antimicrobial Activity of the Carnivorous Plant Dionaea muscipula Against Food-Related Pathogenic and Putrefactive Bacteria

(2013) HIROKAZU OGIHARA et al.   BIOCONTROL SCIENCE

Beyond Topoisomerase Inhibition: Antitumor 1,4-Naphthoquinones as Potential Inhibitors of Human Monoamine Oxidase

(2013) Eduardo Coelho-Cerqueira et al.   Chemical Biology & Drug Design

Interaction of Keap1 Modified by 2-tert-Butyl-1,4-benzoquinone with GSH: Evidence for S-Transarylation

(2013) Yumi Abiko et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phytochemistry of the Carnivorous Sundew GenusDrosera(Droseraceae) - Future Perspectives and Ethnopharmacological Relevance

(2013) Paul A. Egan et al.   CHEMISTRY & BIODIVERSITY

Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells

(2013) I. Andújar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Homogeneous purification and characterization of LePGT1 - a membrane-bound aromatic substrate prenyltransferase involved in secondary metabolism ofLithospermum erythrorhizon

(2013) Kazuaki Ohara et al.   FEBS Journal

Soil hypha-mediated movement of allelochemicals: arbuscular mycorrhizae extend the bioactive zone of juglone

(2013) Michaela Achatz et al.   FUNCTIONAL ECOLOGY

Plumbagin, a Vitamin K3 Analogue, abrogates Lipopolysaccharide-Induced Oxidative Stress, Inflammation and Endotoxic Shock via NF-κB Suppression

(2013) Rahul Checker et al.   INFLAMMATION

Identification of a Hotdog Fold Thioesterase Involved in the Biosynthesis of Menaquinone in Escherichia coli

(2013) M. Chen et al.   JOURNAL OF BACTERIOLOGY

Shikonin Inhibits Thyroid Cancer Cell Growth and Invasiveness Through Targeting Major Signaling Pathways

(2013) Qi Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interventional Effects of Plumbagin on Experimental Ulcerative Colitis in Mice

(2013) Justin E. Pile et al.   JOURNAL OF NATURAL PRODUCTS

Separation and Identification of 1,2,4-Trihydroxynaphthalene-1-O-glucoside in Impatiens glandulifera Royle

(2013) Jan Tříska et al.   MOLECULES

Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability

(2013) Lina Wang et al.   NEUROCHEMICAL RESEARCH

Metabolic profiling in Echium plantagineum: presence of bioactive pyrrolizidine alkaloids and napthoquinones from accessions across southeastern Australia

(2013) Paul A. Weston et al.   PHYTOCHEMISTRY REVIEWS

Cellular responses to naphthoquinones: juglone as a case study

(2013) M. Rudnicka et al.   PLANT GROWTH REGULATION

Pharmacological Properties of Shikonin – A Review of Literature since 2002

(2013) Isabel Andújar et al.   PLANTA MEDICA

Analysis of naphthoquinone derivatives as topoisomerase I inhibitors using fragment based QSAR

(2013) Bastikar Virupaksha et al.   Journal of Cheminformatics

A Wolbachia wMel Transinfection in Aedes albopictus Is Not Detrimental to Host Fitness and Inhibits Chikungunya Virus

(2013) Marcus S. C. Blagrove et al.   PLoS Neglected Tropical Diseases

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

(2013) François Gaascht et al.   Frontiers in Oncology

Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway

(2012) Jing Li et al.   ACTA PHARMACOLOGICA SINICA

Secreted pitfall-trap fluid of carnivorous Nepenthes plants is unsuitable for microbial growth

(2012) Franziska Buch et al.   ANNALS OF BOTANY

Novel Multiple Apoptotic Mechanism of Shikonin in Human Glioma Cells

(2012) Ching-Hsein Chen et al.   ANNALS OF SURGICAL ONCOLOGY

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

(2012) Hiroshi Maeda et al.   Annual Review of Plant Biology

Biosynthesis of Fusarubins Accounts for Pigmentation of Fusarium fujikuroi Perithecia

(2012) Lena Studt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory Effect of Shikonin on Candida albicans Growth

(2012) Hao Miao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antifungal Activity of Maytenin and Pristimerin

(2012) Fernanda P. Gullo et al.   Evidence-based Complementary and Alternative Medicine

Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response

(2012) Kanwal Ahmed et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Potent and Specific Bactericidal Effect of Juglone (5-Hydroxy-1,4-naphthoquinone) on the Fire Blight Pathogen Erwinia amylovora

(2012) Thilo Christopher Fischer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action

(2012) Shantanu Karkare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for cellular transport and release of allelochemicals from plant roots into the rhizosphere

(2012) L. A. Weston et al.   JOURNAL OF EXPERIMENTAL BOTANY

Structure activity relationship of plumbagin in BRCA1 related cancer cells

(2012) Thasni K.A. et al.   MOLECULAR CARCINOGENESIS

Architectures, mechanisms and molecular evolution of natural product methyltransferases

(2012) David K. Liscombe et al.   NATURAL PRODUCT REPORTS

Vitamin Deficiencies in Humans: Can Plant Science Help?

(2012) T. B. Fitzpatrick et al.   PLANT CELL

Phylloquinone (vitamin K1) biosynthesis in plants: two peroxisomal thioesterases of lactobacillales origin hydrolyze 1,4-dihydroxy-2-naphthoyl-coa

(2012) Joshua R. Widhalm et al.   PLANT JOURNAL

Mechanism of Inhibition of the ATPase Domain of Human Topoisomerase IIα by 1,4-Benzoquinone, 1,2-Naphthoquinone, 1,4-Naphthoquinone, and 9,10-Phenanthroquinone

(2012) Deepak Gurbani et al.   TOXICOLOGICAL SCIENCES

The Chemical Biology of Naphthoquinones and Its Environmental Implications

(2011) Yoshito Kumagai et al.   Annual Review of Pharmacology and Toxicology

Topoisomerase I inactivation by a novel thiol reactive naphthoquinone

(2011) Steven Kennedy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ability of the Oriental Fruit Moth Grapholita molesta (Lepidoptera: Tortricidae) to Detoxify Juglone, the Main Secondary Metabolite of the Non-host Plant Walnut

(2011) Rafal Piskorski et al.   JOURNAL OF CHEMICAL ECOLOGY

Distribution of naphthoquinones, plumbagin, droserone, and 5-O-methyl droserone in chitin-induced and uninduced Nepenthes khasiana: molecular events in prey capture

(2011) G. Raj et al.   JOURNAL OF EXPERIMENTAL BOTANY

How the oligophage codling moth Cydia pomonella survives on walnut despite its secondary metabolite juglone

(2011) Rafal Piskorski et al.   JOURNAL OF INSECT PHYSIOLOGY

Synthesis and insect antifeedant activity of plumbagin derivatives

(2011) K. Rajendra Prasad et al.   MEDICINAL CHEMISTRY RESEARCH

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Biosynthetic origin of 2-geranyl-1,4-naphthoquinone and its related anthraquinone in a Sesamum indicum hairy root culture

(2011) Toshio Furumoto et al.   PHYTOCHEMISTRY

Identification of transcriptome profiles and signaling pathways for the allelochemical juglone in rice roots

(2011) Wen-Chang Chi et al.   PLANT MOLECULAR BIOLOGY

Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways

(2011) Yan Jia et al.   PLoS One

Global transcriptional profiles of Mycobacterium tuberculosis treated with plumbagin

(2011) Haiqing Ye et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Diversification of P450 Genes During Land Plant Evolution

(2010) Masaharu Mizutani et al.   Annual Review of Plant Biology

1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes

(2010) Viola Klaus et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

5-Hydroxy-1,4-naphthoquinone (juglone) and 2-hydroxy-1,4-naphthoquinone (lawsone) influence on jack bean urease activity: Elucidation of the difference in inhibition activity

(2010) Mirosława Kot et al.   BIOORGANIC CHEMISTRY

Increased production of naphthoquinones in Impatiens balsamina root cultures by elicitation with methyl jasmonate

(2010) Athip Sakunphueak et al.   BIORESOURCE TECHNOLOGY

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils

(2010) T. Boussetta et al.   BLOOD

Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]

(2010) Ravi S Singh et al.   BMC MOLECULAR BIOLOGY

Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus

(2010) I Andújar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures ofArnebia euchroma(Royle) Johnston, a medicinally important plant species

(2010) Sonia Malik et al.   CELL BIOLOGY INTERNATIONAL

A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis ofEscherichia coli

(2010) Ming Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Isochorismate-derived 2,3-Dihydroxybenzoic 3-O-β-d-Xyloside inArabidopsisResistance to Pathogens and Ageing of Leaves

(2010) Michael Bartsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteome map of spinach leaf peroxisomes indicates partial compartmentalization of phylloquinone (vitamin K1) biosynthesis in plant peroxisomes

(2010) Lavanya Babujee et al.   JOURNAL OF EXPERIMENTAL BOTANY

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor- B Activation

(2010) P. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Perspectives on medicinal properties of plumbagin and its analogs

(2010) Subhash Padhye et al.   MEDICINAL RESEARCH REVIEWS

LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon

(2010) W. Zhang et al.   PLANT BIOLOGY

Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation ofp-hydroxybenzoic acid

(2009) Kazuaki Ohara et al.   BIOCHEMICAL JOURNAL

Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor- B Family

(2009) G. Fan et al.   CANCER RESEARCH

Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells

(2009) B. Kiran Aithal et al.   CELL BIOLOGY INTERNATIONAL

Noteworthy Secondary Metabolites Naphthoquinones – their Occurrence, Pharmacological Properties and Analysis

(2009) Petr Babula et al.   Current Pharmaceutical Analysis

Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes

(2009) Rahul Checker et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana

(2009) H. Eilenberg et al.   JOURNAL OF EXPERIMENTAL BOTANY

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

(2009) Tae Gen Son et al.   JOURNAL OF NEUROCHEMISTRY

The Trypanocidal Activity of Naphthoquinones: A Review

(2009) Antônio Ventura Pinto et al.   MOLECULES

Towards a molecular-level understanding of the reactivity differences for radical anions of juglone and plumbagin: an electrochemical and spectroelectrochemical approach

(2009) Lindsay S. Hernández-Muñoz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biosynthesis of salicylic acid in fungus elicited Catharanthus roseus cells

(2009) Natali R. Mustafa et al.   PHYTOCHEMISTRY

In-Depth Proteome Analysis of Arabidopsis Leaf Peroxisomes Combined with in Vivo Subcellular Targeting Verification Indicates Novel Metabolic and Regulatory Functions of Peroxisomes

(2009) S. Reumann et al.   PLANT PHYSIOLOGY

A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1

(2009) J. R. Widhalm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of hydroxy substituent on the prooxidant action of naphthoquinone compounds

(2009) Keiko Murakami et al.   TOXICOLOGY IN VITRO

Identification and Characterization of (1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate Synthase in the Menaquinone Biosynthesis of Escherichia coli†

(2008) Ming Jiang et al.   BIOCHEMISTRY

The Natural Naphthoquinone Plumbagin Exhibits Antiproliferative Activity and Disrupts the Microtubule Network through Tubulin Binding†

(2008) Bipul R. Acharya et al.   BIOCHEMISTRY

Photosystem I complexes associated with fucoxanthin-chlorophyll-binding proteins from a marine centric diatom, Chaetoceros gracilis

(2008) Yohei Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Polyketides in insects: ecological role of these widespread chemicals and evolutionary aspects of their biogenesis

(2008) Florian Pankewitz et al.   BIOLOGICAL REVIEWS

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold

(2008) M. Kyle Hadden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism of inhibition of tumor angiogenesis by β-hydroxyisovalerylshikonin

(2008) Yusuke Komi et al.   CANCER SCIENCE

Alkannins and Shikonins: A New Class of Wound Healing Agents

(2008) V. Papageorgiou et al.   CURRENT MEDICINAL CHEMISTRY

Naphthoquinones as allelochemical triggers of programmed cell death

(2008) Petr Babula et al.   ENVIRONMENTAL AND EXPERIMENTAL BOTANY

Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis

(2008) Claudia Fila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Red Lapacho (Tabebuia impetiginosa)—A global ethnopharmacological commodity?

(2008) J. Rubén Gómez Castellanos et al.   JOURNAL OF ETHNOPHARMACOLOGY

Plumbagin-induced Apoptosis in Human Prostate Cancer Cells is Associated with Modulation of Cellular Redox Status and Generation of Reactive Oxygen Species

(2008) Anna A. Powolny et al.   PHARMACEUTICAL RESEARCH

Pyrone polyketides synthesized by a type III polyketide synthase from Drosophyllum lusitanicum

(2008) Aphacha Jindaprasert et al.   PHYTOCHEMISTRY

Nitric Oxide Regulates Shikonin Formation in Suspension-Cultured Onosma paniculatum Cells

(2008) S.-J. Wu et al.   PLANT AND CELL PHYSIOLOGY

The AAE14 gene encodes the Arabidopsis o-succinylbenzoyl-CoA ligase that is essential for phylloquinone synthesis and photosystem-I function

(2008) Hyun Uk Kim et al.   PLANT JOURNAL

Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis

(2008) C. Garcion et al.   PLANT PHYSIOLOGY

Plant Polyketide Synthases: A fascinating group of enzymes

(2008) Isvett J. Flores-Sanchez et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms

(2008) T. Hiratsuka et al.   SCIENCE