Achievements and obstacles of remyelinating therapies in multiple sclerosis

Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination

(2017) Veronique E. Miron   JOURNAL OF LEUKOCYTE BIOLOGY

11 C-PBR28 and 18 F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis

(2017) Gourab Datta et al.   JOURNAL OF NUCLEAR MEDICINE

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

g-Ratio weighted imaging of the human spinal cord in vivo

(2017) T. Duval et al.   NEUROIMAGE

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

(2016) Benedetta Bodini et al.   ANNALS OF NEUROLOGY

Evolution of the CNS myelin gene regulatory program

(2016) Huiliang Li et al.   BRAIN RESEARCH

Intracellular signaling pathway regulation of myelination and remyelination in the CNS

(2016) Jenna M. Gaesser et al.   EXPERIMENTAL NEUROLOGY

Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin Imaging

(2016) Anand Dev Tiwari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study

(2016) Caryl J. Schwartzbach et al.   JOURNAL OF NEUROLOGY

Application ofq-Space Diffusion MRI for the Visualization of White Matter

(2016) Kanehiro Fujiyoshi et al.   JOURNAL OF NEUROSCIENCE

Myeloid cells — targets of medication in multiple sclerosis

(2016) Manoj K. Mishra et al.   Nature Reviews Neurology

Characterization of Axonal Disease in Patients with Multiple Sclerosis Using High-Gradient-Diffusion MR Imaging

(2016) Susie Y. Huang et al.   RADIOLOGY

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Pushing Forward: Remyelination as the New Frontier in CNS Diseases

(2016) David Kremer et al.   TRENDS IN NEUROSCIENCES

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

(2015) Yasir A. Syed et al.   ACTA NEUROPATHOLOGICA

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

(2015) Maren Lindner et al.   BRAIN

Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system

(2015) Laura Salinas Tejedor et al.   BRAIN BEHAVIOR AND IMMUNITY

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis

(2015) Paul M Matthews et al.   Expert Opinion on Drug Discovery

Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

(2015) Juan Xiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantification of [11C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

(2015) Mattia Veronese et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

(2015) Jayshree Samanta et al.   NATURE

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

(2015) Sigrid Mensch et al.   NATURE NEUROSCIENCE

Neuronal activity biases axon selection for myelination in vivo

(2015) Jacob H Hines et al.   NATURE NEUROSCIENCE

Control of autoimmune CNS inflammation by astrocytes

(2015) Veit Rothhammer et al.   Seminars in Immunopathology

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing

(2015) Marc C. Ford et al.   Nature Communications

Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

(2015) Hiroaki Wake et al.   Nature Communications

Measuring longitudinal myelin water fraction in new multiple sclerosis lesions

(2015) Wendy S. Vargas et al.   NeuroImage-Clinical

The Role of Astrocytes in Multiple Sclerosis Progression

(2015) Jorge Correale et al.   Frontiers in Neurology

Early netrin-1 expression impairs central nervous system remyelination

(2014) Vanja Tepavčević et al.   ANNALS OF NEUROLOGY

The formation of inflammatory demyelinated lesions in cerebral white matter

(2014) Pietro Maggi et al.   ANNALS OF NEUROLOGY

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Pivotal role of choline metabolites in remyelination

(2014) Thomas Skripuletz et al.   BRAIN

A unified cell biological perspective on axon–myelin injury

(2014) Mikael Simons et al.   JOURNAL OF CELL BIOLOGY

Imaging outcomes for trials of remyelination in multiple sclerosis

(2014) Shahrukh Mallik et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

MRI-based myelin water imaging: A technical review

(2014) Eva Alonso-Ortiz et al.   MAGNETIC RESONANCE IN MEDICINE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema

(2014) Chia-Wen Chiang et al.   NEUROIMAGE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

(2014) Iben Lundgaard et al.   PLOS BIOLOGY

Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis

(2014) Robert A. Brown et al.   NeuroImage-Clinical

Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients

(2014) Robert A. Brown et al.   NeuroImage-Clinical

Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

(2014) Hema Mohan et al.   Acta Neuropathologica Communications

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination

(2013) Tracy J. Yuen et al.   BRAIN

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

(2013) Josephine M. J. Stoffels et al.   BRAIN

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers

(2013) Seonok Lee et al.   Nature Protocols

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin

(2013) B. E. Powers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sample sizes for lesion magnetisation transfer ratio outcomes in remyelination trials for multiple sclerosis

(2013) D.R. Altmann et al.   Multiple Sclerosis and Related Disorders

A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis

(2012) Kurt-Wolfram Sühs et al.   ANNALS OF NEUROLOGY

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Low-contrast acuity measures visual improvement in phase 3 trial of natalizumab in relapsing MS

(2012) Laura J. Balcer et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

(2012) Seonok Lee et al.   NATURE METHODS

Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models

(2012) Lianhua Bai et al.   NATURE NEUROSCIENCE

Segmentation of magnetization transfer ratio lesions for longitudinal analysis of demyelination and remyelination in multiple sclerosis

(2012) Robert A. Brown et al.   NEUROIMAGE

Neural Stem Cell Engraftment and Myelination in the Human Brain

(2012) N. Gupta et al.   Science Translational Medicine

A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values

(2011) R.J. Fox et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

(2011) Gabrièle Piaton et al.   BRAIN

FGF-2 and Anosmin-1 Are Selectively Expressed in Different Types of Multiple Sclerosis Lesions

(2011) D. Clemente et al.   JOURNAL OF NEUROSCIENCE

Fibroblast Growth Factor Signaling Is Required for the Generation of Oligodendrocyte Progenitors from the Embryonic Forebrain

(2011) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis

(2011) Fiona E. Costello et al.   OPHTHALMIC SURGERY LASERS & IMAGING

Quantitative magnetization transfer and myelin water imaging of the evolution of acute multiple sclerosis lesions

(2010) Ives R. Levesque et al.   MAGNETIC RESONANCE IN MEDICINE

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

(2009) Sha Mi et al.   ANNALS OF NEUROLOGY

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

(2009) Alexandra S. Baer et al.   BRAIN

High test–retest reliability of checkerboard reversal visual evoked potentials (VEP) over 8 months

(2009) Johannes Sarnthein et al.   CLINICAL NEUROPHYSIOLOGY

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Direct visualization of remyelination in multiple sclerosis using T2-weighted high-field MRI

(2009) K. Schmierer et al.   NEUROLOGY

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

(2009) Yueting Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions

(2008) Jacqueline T. Chen et al.   ANNALS OF NEUROLOGY

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Longitudinal changes in myelin water fraction in two MS patients with active disease

(2008) I.M. Vavasour et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE