Control of autoimmune CNS inflammation by astrocytes

The role of IL-17 in CNS diseases

(2015) Ari Waisman et al.   ACTA NEUROPATHOLOGICA

Maternal immune activation in late gestation increases neuroinflammation and aggravates experimental autoimmune encephalomyelitis in the offspring

(2015) Adriano Zager et al.   BRAIN BEHAVIOR AND IMMUNITY

Direct immunomodulatory influence of IFN-βon human astrocytoma cells

(2015) Monireh Mohsenzadegan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model

(2015) Tim Clarner et al.   JOURNAL OF IMMUNOLOGY

Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression

(2014) Tomohiro Fukaya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptor signaling directly increases functional IL-17RA expression in neuroglial cells

(2014) Guoping Liu et al.   CLINICAL IMMUNOLOGY

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

Regulatory T cells in autoimmune neuroinflammation

(2014) Markus Kleinewietfeld et al.   IMMUNOLOGICAL REVIEWS

Efficacy of Canakinumab vs. triamcinolone acetonide according to multiple gouty arthritis-related health outcomes measures

(2014) J. D. Hirsch et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling

(2014) Yichuan Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation

(2014) Craig S. Moore et al.   JOURNAL OF IMMUNOLOGY

IL-17A Induces MIP-1α Expression in Primary Astrocytes via Src/MAPK/PI3K/NF-kB Pathways: Implications for Multiple Sclerosis

(2014) Hongwei Yi et al.   Journal of Neuroimmune Pharmacology

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

(2014) Debayon Paul et al.   Journal of Neuroinflammation

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

(2014) Emily Mills Ko et al.   Journal of Neuroinflammation

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Theiler’s virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors

(2014) Nazario Rubio et al.   JOURNAL OF NEUROVIROLOGY

The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes

(2014) Min-Fang Guo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients

(2014) Masoumeh Heidary et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies

(2014) Dean M. Wingerchuk et al.   MAYO CLINIC PROCEEDINGS

The Biological Functions, Structure and Sources of CXCL10 and Its Outstanding Part in the Pathophysiology of Multiple Sclerosis

(2014) Reza Vazirinejad et al.   NEUROIMMUNOMODULATION

ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells: Possible involvement in CXCL10 expression

(2014) Tadaatsu Imaizumi et al.   NEUROSCIENCE RESEARCH

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

(2014) Christina Heinemann et al.   Nature Communications

Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination

(2014) Hema Mohan et al.   Acta Neuropathologica Communications

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

(2013) Xu Wang et al.   ACTA NEUROPATHOLOGICA

Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation

(2013) Zichen Li et al.   BMC IMMUNOLOGY

CXCL12-γ expression is inhibited in neuroinflammation

(2013) Gordana Timotijević et al.   BRAIN RESEARCH

Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6

(2013) Mercedes Giralt et al.   GLIA

High interleukin-10 expression within the central nervous system may be important for initiation of recovery of Dark Agouti rats from experimental autoimmune encephalomyelitis

(2013) Jana Blaževski et al.   IMMUNOBIOLOGY

Nitric oxide inhibits CXCL12 expression in neuroinflammation

(2013) Filip Petković et al.   IMMUNOLOGY AND CELL BIOLOGY

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

(2013) Celina Wu et al.   Journal of Neuroinflammation

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER  Signaling on Astrocytes But Not through ER  Signaling on Astrocytes or Neurons

(2013) R. D. Spence et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis

(2013) T. W. Phares et al.   JOURNAL OF VIROLOGY

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

MDA5 and ISG56 mediate CXCL10 expression induced by Toll-like receptor 4 activation in U373MG human astrocytoma cells

(2013) Tadaatsu Imaizumi et al.   NEUROSCIENCE RESEARCH

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

(2012) Randall D. Wight et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Mitoxantrone repression of astrocyte activation: Relevance to multiple sclerosis

(2012) Samuel A. Burns et al.   BRAIN RESEARCH

Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis (EAE) in mice

(2012) J. F. Yang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model

(2012) Ana Karolina de Santana Nunes et al.   CYTOKINE

Regulation of CCL20 expression in astrocytes by IL-6 and IL-17

(2012) Gordon P. Meares et al.   GLIA

CXCL12 in control of neuroinflammation

(2012) Miljana Momcilović et al.   IMMUNOLOGIC RESEARCH

The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis

(2012) Shujun Ge et al.   Journal of Neuroinflammation

CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

(2012) Yaping Yan et al.   MOLECULAR THERAPY

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability

(2012) Claudia Hindinger et al.   PLoS One

The dual role of CXCL8 in human CNS stem cell function: Multipotent neural stem cell death and oligodendrocyte progenitor cell chemotaxis

(2011) Eve E. Kelland et al.   GLIA

Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

(2011) F. Haroon et al.   JOURNAL OF IMMUNOLOGY

IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by Astrocytes

(2011) Yan Zhou et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

(2011) Sarah Al-Izki et al.   Multiple Sclerosis Journal

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats

(2010) Xiao-Li Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: Implications for HIV-1-induced neurodegeneration

(2010) Tao Jing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

(2010) Sadayuki Hashioka et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Regulatory T cells and inhibitory cytokines in autoimmunity

(2009) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis

(2009) A. Quintana et al.   JOURNAL OF IMMUNOLOGY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis

(2009) Eve A. Subileau et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in aicardi-Goutières syndrome

(2008) Jane T. Van Heteren et al.   GLIA

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

(2008) Moran Meiron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1β and TNF-α: Involvement of mitogen-activated protein kinases and protein kinase R

(2008) Jialin C. Zheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling

(2007) Xiaoxia Li   CYTOKINE

Role of astrocytes and chemokine systems in acute TNFα induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-κB and Akt

(2007) Marlon P. Quinones et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

(2007) M LI et al.   PROGRESS IN NEUROBIOLOGY