Myeloid cells — targets of medication in multiple sclerosis

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation

(2016) Fernanda V. Duraes et al.   JOURNAL OF AUTOIMMUNITY

Pivotal Role for CD16+Monocytes in Immune Surveillance of the Central Nervous System

(2016) Anne Waschbisch et al.   JOURNAL OF IMMUNOLOGY

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

(2015) Agata A. Mossakowski et al.   ACTA NEUROPATHOLOGICA

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis

(2015) Felix Luessi et al.   Multiple Sclerosis Journal

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

(2015) Iftach Shaked et al.   NATURE IMMUNOLOGY

Central nervous system myeloid cells as drug targets: current status and translational challenges

(2015) Knut Biber et al.   NATURE REVIEWS DRUG DISCOVERY

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation

(2015) Rebecca A. Sosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

(2015) Rui Li et al.   Science Translational Medicine

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis

(2015) Felix Luessi et al.   Multiple Sclerosis Journal

Interferon Beta and Vitamin D Synergize to Induce Immunoregulatory Receptors on Peripheral Blood Monocytes of Multiple Sclerosis Patients

(2015) Anne Waschbisch et al.   PLoS One

Microglia: unique and common features with other tissue macrophages

(2014) Marco Prinz et al.   ACTA NEUROPATHOLOGICA

Mode of action and clinical studies with alemtuzumab

(2014) Joanne L. Jones et al.   EXPERIMENTAL NEUROLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis

(2014) De-Hyung Lee et al.   JOURNAL OF NEUROIMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Laquinimod reduces neuroaxonal injury through inhibiting microglial activation

(2014) Manoj Kumar Mishra et al.   Annals of Clinical and Translational Neurology

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis

(2013) Smriti M. Agrawal et al.   BRAIN

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis

(2013) Valérie Jolivel et al.   BRAIN

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis

(2013) Khalil S. Rawji et al.   Clinical & Developmental Immunology

Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis

(2013) Chris L. Ayers et al.   CLINICAL IMMUNOLOGY

Drugs in Development for Relapsing Multiple Sclerosis

(2013) Rehiana Ali et al.   DRUGS

Circulating Monocytes Are Reduced by Sphingosine-1-Phosphate Receptor Modulators Independently of S1P3

(2013) N. D. Lewis et al.   JOURNAL OF IMMUNOLOGY

Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod

(2013) Brett T. Lund et al.   JOURNAL OF NEUROIMMUNOLOGY

The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro

(2013) Li Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

(2013) Scott Sloka et al.   Journal of Neuroinflammation

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Vitamin D3, Calcipotriol and FTY720 on the Expression of Surface Molecules and Cytolytic Activities of Human Natural Killer Cells and Dendritic Cells

(2013) Zaidoon Al-Jaderi et al.   Toxins

Teriflunomide Attenuates Immunopathological Changes in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis

(2013) Garth E. Ringheim et al.   Frontiers in Neurology

Kinetics of Proinflammatory Monocytes in a Model of Multiple Sclerosis and Its Perturbation by Laquinimod

(2012) Manoj K. Mishra et al.   AMERICAN JOURNAL OF PATHOLOGY

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic cell, monocyte and T cell activation and response to glatiramer acetate in multiple sclerosis

(2012) F. Sellebjerg et al.   Multiple Sclerosis Journal

Increased PK11195 PET binding in the cortex of patients with MS correlates with disability

(2012) M. Politis et al.   NEUROLOGY

Heterogeneity of cortical lesions in multiple sclerosis: Clinical and pathologic implications

(2012) E.-J. Kooi et al.   NEUROLOGY

Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity

(2012) Ulf Schulze-Topphoff et al.   PLoS One

Glatiramer Acetate Increases Phagocytic Activity of Human Monocytes In Vitro and in Multiple Sclerosis Patients

(2012) Refik Pul et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease

(2012) Laura Codarri et al.   TRENDS IN IMMUNOLOGY

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor

(2011) Jan Thöne et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Preactive Multiple Sclerosis Lesions Offer Novel Clues for Neuroprotective Therapeutic Strategies

(2011) Johannes M. van Noort et al.   CNS & Neurological Disorders-Drug Targets

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis

(2011) Raquel Planas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

(2011) Nils Schweingruber et al.   JOURNAL OF IMMUNOLOGY

Dimethyl Fumarate, an Immune Modulator and Inducer of the Antioxidant Response, Suppresses HIV Replication and Macrophage-Mediated Neurotoxicity: A Novel Candidate for HIV Neuroprotection

(2011) Stephanie A. Cross et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Glucocorticoids in the Control of Neuroinflammation

(2011) N. Schweingruber et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fingolimod modulates microglial activation to augment markers of remyelination

(2011) Samuel J Jackson et al.   Journal of Neuroinflammation

Decreased microglial activation in MS patients treated with glatiramer acetate

(2011) John N. Ratchford et al.   JOURNAL OF NEUROLOGY

EMMPRIN: A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2011) S. M. Agrawal et al.   JOURNAL OF NEUROSCIENCE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Radical changes in multiple sclerosis pathogenesis

(2010) Jack van Horssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

The Potential Role of B Cell-Targeted Therapies in Multiple Sclerosis

(2010) Aaron Boster et al.   DRUGS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

IFN-  Inhibits Dendritic Cell Migration through STAT-1-Mediated Transcriptional Suppression of CCR7 and Matrix Metalloproteinase 9

(2010) J.-H. Yen et al.   JOURNAL OF IMMUNOLOGY

Glatiramer Acetate Modulates TNF-α and IL-10 Secretion in Microglia and Promotes Their Phagocytic Activity

(2010) Refik Pul et al.   Journal of Neuroimmune Pharmacology

Differential responses of human microglia and blood-derived myeloid cells to FTY720

(2010) Bryce A. Durafourt et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis

(2010) Owain W. Howell et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

Inflammation in Neurological Disorders: A Help or a Hindrance?

(2010) V. Wee Yong   NEUROSCIENTIST

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Interferon   induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation

(2009) J.-H. Yen et al.   BLOOD

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

A type I interferon signature in monocytes is associated with poor response to interferon-β in multiple sclerosis

(2009) M. Comabella et al.   BRAIN

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Pharmacological Treatment of Early Multiple Sclerosis

(2009) Olaf Stüve et al.   DRUGS

Ocrelizumab: a step forward in the evolution of B-cell therapy

(2009) Fariha Kausar et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy

(2009) Mitosek-Szewczyk Krystyna et al.   JOURNAL OF NEUROIMMUNOLOGY

Interferon-  mechanisms of action in multiple sclerosis

(2009) S. Dhib-Jalbut et al.   NEUROLOGY

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE

Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone®)

(2008) C Iarlori et al.   Multiple Sclerosis Journal