Screening a Natural Product-Based Library against Kinetoplastid Parasites

Neglected tropical diseases: progress towards addressing the chronic pandemic

(2017) David H Molyneux et al.   LANCET

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity

(2017) Julia B. Althaus et al.   MOLECULES

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Current drug therapy and pharmaceutical challenges for Chagas disease

(2016) José Bermudez et al.   ACTA TROPICA

Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

(2016) Keisuke Suganuma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

(2016) Emma C. Barnes et al.   NATURAL PRODUCT REPORTS

Leishmania infection: painful or painless?

(2016) Sergio M. Borghi et al.   PARASITOLOGY RESEARCH

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

(2016) Annelies Mondelaers et al.   PLoS One

Human African trypanosomiasis prevention, treatment and control costs: A systematic review

(2015) Joseph Keating et al.   ACTA TROPICA

Autoimmune Pathogenesis of Chagas Heart Disease

(2015) Kevin M. Bonney et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis

(2015) Amy J. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminothiazoles: Hit to lead development to identify antileishmanial agents

(2015) Debnath Bhuniya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Future treatment options for human African trypanosomiasis

(2015) Amy J Jones et al.   Expert Review of Anti-Infective Therapy

Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity

(2015) Charles E. Mowbray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

(2015) Brett Schwartz et al.   Marine Drugs

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

(2015) Brett D. Schwartz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

(2015) Vanida Choomuenwai et al.   PHYTOCHEMISTRY

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

(2015) Melissa L. Sykes et al.   International Journal for Parasitology-Drugs and Drug Resistance

An update on pharmacotherapy for leishmaniasis

(2014) Shyam Sundar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert

(2014) Mônica C.O. Campos et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Determinants of disease phenotype in trypanosomatid parasites

(2014) Laura-Isobel McCall et al.   TRENDS IN PARASITOLOGY

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

(2014) Joseph D. Planer et al.   PLoS Neglected Tropical Diseases

Inhibition ofLeishmania infantumTrypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography

(2013) Paola Baiocco et al.   ChemMedChem

Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi

(2013) Matheus Andrade Rajão et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Thiaplakortones A–D: Antimalarial Thiazine Alkaloids from the Australian Marine Sponge Plakortis lita

(2013) Rohan A. Davis et al.   JOURNAL OF ORGANIC CHEMISTRY

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate

(2013) Holly Matthews et al.   MALARIA JOURNAL

Trypanocidal Activity of Marine Natural Products

(2013) Amy Jones et al.   Marine Drugs

Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase

(2013) TOMOAKI BESSHO et al.   PARASITOLOGY

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB

(2013) Jörg Schröder et al.   PLoS One

The discovery, synthesis and antimalarial evaluation of natural product-based polyamine alkaloids

(2013) Vanida Choomuenwai et al.   TETRAHEDRON LETTERS

Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

(2012) Vanida Choomuenwai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.

(2012) Yunjiang Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors

(2012) Paola Corona et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cloning, characterization and validation of inosine 5′-monophosphate dehydrogenase of Babesia gibsoni as molecular drug target

(2012) Shinuo Cao et al.   PARASITOLOGY INTERNATIONAL

Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis

(2012) Claire Levrier et al.   PHYTOCHEMISTRY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

(2012) Lucio H. Freitas-Junior et al.   International Journal for Parasitology-Drugs and Drug Resistance

Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness

(2011) Marcel Kaiser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa

(2011) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

A review of antimalarial plants used in traditional medicine in communities in Portuguese-Speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola

(2011) Jefferson Rocha de A Silva et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Pseudoceramines A–D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

(2011) Sheng Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A New Quinoline Epoxide from the Australian PlantDrummondita calida

(2011) Xinzhou Yang et al.   PLANTA MEDICA

Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens

(2011) Solomon Nwaka et al.   PLoS Neglected Tropical Diseases

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

(2010) Mariana Boiani et al.   BIOCHEMICAL PHARMACOLOGY

Michael Acceptor Based Antiplasmodial and Antitrypanosomal Cysteine Protease Inhibitors with Unusual Amino Acids

(2010) Alexander Breuning et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial Bromotyrosine Derivatives from the Australian Marine SpongeHyattellasp.

(2010) Xinzhou Yang et al.   JOURNAL OF NATURAL PRODUCTS

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

Development of an Alamar Blue™ Viability Assay in 384-Well Format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei Bloodstream Form Strain 427

(2009) Melissa L. Sykes et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase

(2009) Andrea Cavalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

(2009) Chidochangu P. Mpamhanga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides

(2009) Emma C. Barnes et al.   TETRAHEDRON

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)

(2008) Vera Rosenkranz et al.   MOLECULES