The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid

(2015) Rohitesh Kumar et al.   JOURNAL OF NATURAL PRODUCTS

Analysis of Physicochemical Properties for Drugs of Natural Origin

(2015) David Camp et al.   JOURNAL OF NATURAL PRODUCTS

Design and synthesis of analogues of natural products

(2015) Martin E. Maier   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a Natural-Product-Derived Chemical Toolbox for Modulation of Protein Function

(2014) Stefano Rizzo et al.   CHEMICAL REVIEWS

Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone, a sesquiterpene from Inula britannica

(2014) Shuai Dong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemo- and site-selective derivatizations of natural products enabling biological studies

(2014) Omar Robles et al.   NATURAL PRODUCT REPORTS

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Solid-Phase Library Synthesis of Bi-Functional Derivatives of Oleanolic and Maslinic Acids and Their Cytotoxicity on Three Cancer Cell Lines

(2014) Andres Parra et al.   ACS Combinatorial Science

Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion

(2013) Ahmed I. Foudah et al.   ChemMedChem

Natural products as lead structures: chemical transformations to create lead-like libraries

(2013) Mauro Pascolutti et al.   DRUG DISCOVERY TODAY

Synthesis of novel guttiferone A derivatives: In-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani

(2013) Yann Fromentin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors

(2013) Ahmed I. Foudah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enhancing Macrocyclic Diterpenes as Multidrug-Resistance Reversers: Structure–Activity Studies on Jolkinol D Derivatives

(2013) Mariana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural products as starting points for the synthesis of complex and diverse compounds

(2013) Karen C. Morrison et al.   NATURAL PRODUCT REPORTS

Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

(2012) Vanida Choomuenwai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Guiding principles for natural product drug discovery

(2012) David Camp et al.   Future Medicinal Chemistry

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Design and synthesis of screening libraries based on the muurolane natural product scaffold

(2012) Emma C. Barnes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors

(2011) Hossam M. Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure−Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections

(2009) Jiangnan Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts

(2009) Chad A. Lewis et al.   JOURNAL OF NATURAL PRODUCTS

Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379

(2008) Masaki Tomishima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin

(2008) Masaki Tomishima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Activities of Thio-avarol Derivatives#

(2008) Boris Pejin et al.   JOURNAL OF NATURAL PRODUCTS

Scaffold diversity of natural products: inspiration for combinatorial library design

(2008) Kristina Grabowski et al.   NATURAL PRODUCT REPORTS