A New Quinoline Epoxide from the Australian Plant Drummondita calida

A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the purification of a new quinoline alkaloid, (2'R)-2',3'-epoxy-N-methylatanine (1), along with eight known natural products, skimmianin (2), gamma-fagarine (3), maculosidine (4), evolitrine (5), dictamnine (6), pteleine (7), N-methylatanine (8), and werneria chromene (9). Compound 1 displayed 74% inhibition at 80 mu M against a chloroquine-resistant Plasmodium falciparum strain (Dd2).