Trypanocidal Activity of Marine Natural Products

In VitroandIn VivoStudies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

(2013) Maria de Nazaré Correia Soeiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Whole-organism high-throughput screening againstTrypanosoma brucei brucei

(2013) Amy J Jones et al.   Expert Opinion on Drug Discovery

Approaches to Protozoan Drug Discovery: Phenotypic Screening

(2013) Melissa L. Sykes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

(2013) Laura M. Sanchez et al.   JOURNAL OF NATURAL PRODUCTS

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.

(2012) Yunjiang Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

Brentuximab Vedotin

(2012) C. Deng et al.   CLINICAL CANCER RESEARCH

Safety of benznidazole use in the treatment of chronic Chagas' disease

(2012) A. M. Hasslocher-Moreno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products

(2012) Claudia Strobel et al.   Lipids in Health and Disease

Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus

(2012) Sergio Martínez-Luis et al.   MOLECULES

Marine natural products

(2012) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin

(2012) Giuseppina Chianese et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign

(2012) Melissa L. Sykes et al.   PLoS Neglected Tropical Diseases

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

(2012) Shamila S. Gunatilleke et al.   PLoS Neglected Tropical Diseases

Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness

(2011) Marcel Kaiser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa

(2011) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

(2011) Lisvane Silva Paes et al.   CURRENT PHARMACEUTICAL DESIGN

State of the Art in African Trypanosome Drug Discovery

(2011) Robert T. Jacobs et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antimalarial β-Carbolines from the New Zealand AscidianPseudodistoma opacum

(2011) Susanna T. S. Chan et al.   JOURNAL OF NATURAL PRODUCTS

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities

(2011) Sheila M. Pimentel-Elardo et al.   Marine Drugs

Cytarabine Dose for Acute Myeloid Leukemia

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of Marine-Derived 3-Alkylpyridinium Alkaloids with Potent Antiprotozoal Activity

(2011) Boris Rodenko et al.   ACS Medicinal Chemistry Letters

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

(2011) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi

(2010) Katharine R. Watts et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tolerance and Safety of Nifurtimox in Patients with Chronic Chagas Disease

(2010) Yves Jackson et al.   CLINICAL INFECTIOUS DISEASES

Recent Insights into the Biosynthesis and Biological Activities of Natural Xanthones

(2010) H. El-Seedi et al.   CURRENT MEDICINAL CHEMISTRY

Chronic Chagas’ heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine

(2010) Silvia Gilka Muñoz-Saravia et al.   HEART FAILURE REVIEWS

Effects of the calpain inhibitor MDL28170 on the clinically relevant forms of Trypanosoma cruzi in vitro

(2010) V. Ennes-Vidal et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Manadoperoxides A−D from the Indonesian SpongePlakortiscfr.simplex. Further Insights on the Structure−Activity Relationships of Simple 1,2-Dioxane Antimalarials

(2010) Caterina Fattorusso et al.   JOURNAL OF NATURAL PRODUCTS

Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine SpongePlakortissp.

(2010) Yunjiang Feng et al.   JOURNAL OF NATURAL PRODUCTS

Antiprotozoal Steroidal Saponins from the Marine SpongePandaros acanthifolium

(2010) Erik L. Regalado et al.   JOURNAL OF NATURAL PRODUCTS

Chagas disease

(2010) Anis Rassi et al.   LANCET

Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites

(2010) Fernando Scala et al.   Marine Drugs

Inhibitory Activity of Marine Sponge-Derived Natural Products against Parasitic Protozoa

(2010) Ilkay Orhan et al.   Marine Drugs

In vitro and in vivo experimental models for drug screening and development for Chagas disease

(2010) Alvaro José Romanha et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

The promise of T. cruzi genomics

(2010) Julie Clayton   NATURE

Chagas disease: pushing through the pipeline

(2010) Julie Clayton   NATURE

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

(2010) Julie A. Frearson et al.   NATURE

Acanthifoliosides, minor steroidal saponins from the Caribbean sponge Pandaros acanthifolium

(2010) Erik L. Regalado et al.   TETRAHEDRON

Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum

(2010) Yunjiang Feng et al.   TETRAHEDRON LETTERS

Current and developing therapeutic agents in the treatment of Chagas disease

(2010) Werner Apt   Drug Design Development and Therapy

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

(2010) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives

(2009) C. Dardonville et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

(2009) R. H. Barker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trypanocidal Activity of 8-Methyl-5'- Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

(2009) C. J. Bacchi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

(2009) Naveen Kumar Chennamaneni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy

(2009) Álvaro Moncayo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase inTrypanosoma bruceiusing chemical and genetic methods

(2009) Susan Wyllie et al.   MOLECULAR MICROBIOLOGY

Screening of Agelasine D and Analogs for Inhibitory Activity against Pathogenic Protozoa; Identification of Hits for Visceral Leishmaniasis and Chagas Disease

(2009) Anders Vik et al.   MOLECULES

Trypanosoma cruzitargets for new chemotherapeutic approaches

(2008) Maria Nazaré C Soeiro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides fromMicrocystis aeruginosaPCC 7806 and Their Antiparasite Evaluation

(2008) Cyril Portmann et al.   JOURNAL OF NATURAL PRODUCTS

Antiprotozoal Activities of Heterocyclic-Substituted Xanthones from the Marine-Derived FungusChaetomiumsp.

(2008) Alexander Pontius et al.   JOURNAL OF NATURAL PRODUCTS

Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine SpongePlakortis angulospiculatusCollected in Brazil#

(2008) Miriam H. Kossuga et al.   JOURNAL OF NATURAL PRODUCTS