Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi
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Title
Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi
Authors
Keywords
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Journal
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Volume 55, Issue 4, Pages 309-321
Publisher
Wiley
Online
2013-12-18
DOI
10.1002/em.21839
References
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- Functional Characterization of 8-Oxoguanine DNA Glycosylase of Trypanosoma cruzi
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- Chagas disease
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- DNA Repair in Mammalian Cells
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- Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage
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- Homologous recombination in DNA repair and DNA damage tolerance
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- Biochemical studies with DNA polymerase β and DNA polymerase β-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
- (2008) Débora de Oliveira Lopes et al. DNA REPAIR
- DNA polymerase kappa fromTrypanosoma cruzilocalizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediate
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- A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
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