The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

(2011) Paul G. Wyatt et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visceral leishmaniasis: elimination with existing interventions

(2011) Greg Matlashewski et al.   LANCET INFECTIOUS DISEASES

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

(2010) A. Y. Sokolova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice

(2010) Tamara Olenyik et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Control of Visceral Leishmaniasis in Latin America—A Systematic Review

(2010) Gustavo A. S. Romero et al.   PLoS Neglected Tropical Diseases

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects

(2009) A. M. Ginsberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitsunobu and Related Reactions: Advances and Applications

(2009) K. C. Kumara Swamy et al.   CHEMICAL REVIEWS

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

(2009) Upasna Gaur et al.   EXPERIMENTAL PARASITOLOGY

Developments in the treatment of visceral leishmaniasis

(2009) Margriet Leontine den Boer et al.   EXPERT OPINION ON EMERGING DRUGS

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

(2008) E. Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL