Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Reduced Efficacy of Anti-A  Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity

(2016) E. M. Weekman et al.   JOURNAL OF NEUROSCIENCE

Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy

(2016) A. Manousopoulou et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Prenatal high-fat diet alters the cerebrovasculature and clearance ofβ-amyloid in adult offspring

(2015) Cheryl A Hawkes et al.   JOURNAL OF PATHOLOGY

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(2012) Karolien Bettens et al.   Molecular Neurodegeneration

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition

(2011) Carlo Condello et al.   Scientific Reports

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

Replication of CLU, CR1, and PICALM Associations With Alzheimer Disease

(2010) Minerva M. Carrasquillo et al.   ARCHIVES OF NEUROLOGY

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

(2010) Jason J. Corneveaux et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Expression of clusterin in normal and preeclamptic placentas

(2008) Jeong-Kyu Shin et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications

(2008) Joseph El Khoury et al.   TRENDS IN PHARMACOLOGICAL SCIENCES