标题
Practical considerations for choosing a mouse model of Alzheimer’s disease
作者
关键词
Transgenic mouse, Knockout, Knock-in, Amyloid precursor protein, APP, Aβ, Tau, MAPT, TREM2, Apolipoprotein E, ApoE
出版物
Molecular Neurodegeneration
Volume 12, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-12-22
DOI
10.1186/s13024-017-0231-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Reduction in open field activity in the absence of memory deficits in the App NL−G−F knock-in mouse model of Alzheimer’s disease
- (2018) Lauren S. Whyte et al. BEHAVIOURAL BRAIN RESEARCH
- Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease
- (2017) Alexandra J. Mably et al. HIPPOCAMPUS
- Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
- (2017) Silvia S Kang et al. HUMAN MOLECULAR GENETICS
- Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy
- (2017) Lucia Buccarello et al. JOURNAL OF ALZHEIMERS DISEASE
- Challenges and opportunities in limiting abdominal aortic aneurysm growth
- (2017) Jonathan Golledge et al. JOURNAL OF VASCULAR SURGERY
- Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
- (2017) Anastasia G. Efthymiou et al. Molecular Neurodegeneration
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
- (2017) Na Zhao et al. NEURON
- Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways
- (2017) Aleksandra M. Wojtas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel
- (2017) Yunyao Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease
- (2017) Robert J. Andrew et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential Incorporation of Tau Isoforms in Alzheimer's Disease
- (2017) Marisol Espinoza et al. JOURNAL OF ALZHEIMERS DISEASE
- Apparent Behavioral Benefits of Tau Overexpression in P301L Tau Transgenic Mice
- (2017) Dave Morgan et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer’s disease: experimental models and reality
- (2016) Eleanor Drummond et al. ACTA NEUROPATHOLOGICA
- Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex
- (2016) Fani Koukouli et al. Aging-US
- Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice
- (2016) Sumihiro Maeda et al. EMBO REPORTS
- A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve
- (2016) Matthew W. Granger et al. JOURNAL OF ALZHEIMERS DISEASE
- Soluble Conformers of A and Tau Alter Selective Proteins Governing Axonal Transport
- (2016) M. A. Sherman et al. JOURNAL OF NEUROSCIENCE
- Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
- (2016) T. Saito et al. JOURNAL OF NEUROSCIENCE
- Gamma frequency entrainment attenuates amyloid load and modifies microglia
- (2016) Hannah F. Iaccarino et al. NATURE
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Cognitive deficits in single App knock-in mouse models
- (2016) Akira Masuda et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
- (2016) Sarah K. Kaufman et al. NEURON
- Impaired burrowing is the most prominent behavioral deficit of aging htau mice
- (2016) Philippine Camilla Geiszler et al. NEUROSCIENCE
- Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease
- (2016) T.L. Platt et al. NEUROSCIENCE
- IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
- (2016) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction
- (2016) Michael J. Yetman et al. PLoS One
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
- (2015) Adam K. Walker et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
- (2015) Nicole Maphis et al. BRAIN
- Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
- (2015) Rik van der Kant et al. DEVELOPMENTAL CELL
- Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
- (2015) Sujeong Yang et al. EXPERIMENTAL NEUROLOGY
- Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model
- (2015) Casey Cook et al. HUMAN MOLECULAR GENETICS
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2015) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
- (2015) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
- (2015) Sang-Won Min et al. NATURE MEDICINE
- Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance
- (2015) Linda Madisen et al. NEURON
- Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model
- (2015) Shu-Sheng Jiao et al. NEUROTOXICITY RESEARCH
- Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile
- (2015) Peng Liu et al. PLoS One
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
- (2015) Guilian Xu et al. Acta Neuropathologica Communications
- DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease
- (2015) Harriet M. Jackson et al. PLoS One
- Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains
- (2014) Susana Boluda et al. ACTA NEUROPATHOLOGICA
- Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
- (2014) V. A. Polito et al. EMBO Molecular Medicine
- Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
- (2014) Edgar Dawkins et al. JOURNAL OF NEUROCHEMISTRY
- Genetic Modulation of Soluble A Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease
- (2014) S. W. Fowler et al. JOURNAL OF NEUROSCIENCE
- Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
- (2014) H. A. Born et al. JOURNAL OF NEUROSCIENCE
- Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
- (2014) Hongmei Li et al. Molecular Neurodegeneration
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain
- (2014) Mustafa Aras et al. PEDIATRIC NEUROSURGERY
- Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid- accumulation modifier
- (2014) T. Morihara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteopathic tau seeding predicts tauopathy in vivo
- (2014) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
- (2014) Scott J. Webster et al. Frontiers in Genetics
- Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model
- (2013) Marcio Lazzarini et al. GLIA
- A Rapid Gene Delivery-Based Mouse Model for Early-Stage Alzheimer Disease-Type Tauopathy
- (2013) Robert Siman et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Repetitive Mild Traumatic Brain Injury Augments Tau Pathology and Glial Activation in Aged hTau Mice
- (2013) Joseph-Olubunmi Ojo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis
- (2013) T. Melnikova et al. JOURNAL OF NEUROSCIENCE
- Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
- (2013) M. Iba et al. JOURNAL OF NEUROSCIENCE
- Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
- (2013) William A Eimer et al. Molecular Neurodegeneration
- Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain
- (2013) Raphaëlle Caillierez et al. MOLECULAR THERAPY
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau
- (2013) Qinxi Guo et al. PLoS One
- Effective combination of human bone marrow mesenchymal stem cells and minocycline in experimental autoimmune encephalomyelitis mice
- (2013) Yun Hou et al. Stem Cell Research & Therapy
- Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
- (2013) Scott J Webster et al. Alzheimers Research & Therapy
- Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
- (2013) E.-M. Mandelkow et al. Cold Spring Harbor Perspectives in Medicine
- Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model
- (2013) Jingheng Cheng et al. eLife
- Strain Background Influences Neurotoxicity and Behavioral Abnormalities in Mice Expressing the Tetracycline Transactivator
- (2012) H. J. Han et al. JOURNAL OF NEUROSCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
- (2012) Shaefali P Rodgers et al. Molecular Neurodegeneration
- Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased A� Accumulation and Microglial Activation
- (2012) J.J. Gallagher et al. Neurodegenerative Diseases
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- PGC-1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
- (2012) T. Tsunemi et al. Science Translational Medicine
- Cognitive phenotyping of amyloid precursor protein transgenic J20 mice
- (2011) Tim Karl et al. BEHAVIOURAL BRAIN RESEARCH
- A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
- (2011) Prem K. Premsrirut et al. CELL
- ApoE is required for maintenance of the dentate gyrus neural progenitor pool
- (2011) C.-P. Yang et al. DEVELOPMENT
- Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
- (2011) Hung-Kai Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Biology and pathophysiology of the amyloid precursor protein
- (2011) Hui Zheng et al. Molecular Neurodegeneration
- Neuronal activity regulates the regional vulnerability to amyloid-β deposition
- (2011) Adam W Bero et al. NATURE NEUROSCIENCE
- Combination therapy prevents amyloid-dependent and -independent structural changes
- (2011) Gauri Malthankar-Phatak et al. NEUROBIOLOGY OF AGING
- Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction
- (2011) Melissa J. Alldred et al. NEUROBIOLOGY OF DISEASE
- Multiple Forms of Activity-Dependent Competition Refine Hippocampal Circuits In Vivo
- (2011) Masahiro Yasuda et al. NEURON
- P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating
- (2011) Hiroki Takeuchi et al. PLoS One
- Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau
- (2010) Dara L. Dickstein et al. Brain Structure & Function
- Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity
- (2010) Izumi Maezawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
- (2010) K. R. Brunden et al. JOURNAL OF NEUROSCIENCE
- Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
- (2010) Sadim Jawhar et al. NEUROBIOLOGY OF AGING
- Regulation of Tau Pathology by the Microglial Fractalkine Receptor
- (2010) Kiran Bhaskar et al. NEURON
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Visualizing the Distribution of Synapses from Individual Neurons in the Mouse Brain
- (2010) Ling Li et al. PLoS One
- Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
- (2010) Latha Devi et al. Molecular Brain
- Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
- (2010) Claire J. Garwood et al. Frontiers in Psychiatry
- Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin
- (2009) Kiren Ubhi et al. ACTA NEUROPATHOLOGICA
- Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology
- (2009) M. Polydoro et al. JOURNAL OF NEUROSCIENCE
- The role of tau in neurodegeneration
- (2009) Tania F Gendron et al. Molecular Neurodegeneration
- Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy
- (2009) Mei Yue et al. NEUROBIOLOGY OF AGING
- Doxycycline is Neuroprotective Against Nigral Dopaminergic Degeneration by a Dual Mechanism Involving MMP-3
- (2009) Yuri Cho et al. NEUROTOXICITY RESEARCH
- AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
- (2009) Tomasz Jaworski et al. PLoS One
- Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
- (2008) Chiho Hirata-Fukae et al. BRAIN RESEARCH
- rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse
- (2008) Mitsuru Morimoto et al. DEVELOPMENTAL BIOLOGY
- Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP
- (2008) Rita Joao Guerreiro et al. NEUROBIOLOGY OF AGING
- Gender-Specific Neuroimmunoendocrine Aging in a Triple-Transgenic 3×Tg-AD Mouse Model for Alzheimer’s Disease and Its Relation with Longevity
- (2008) Lydia Giménez-Llort et al. NEUROIMMUNOMODULATION
- Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation
- (2008) M. Osinde et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease
- (2007) Davis Ryman et al. NEUROBIOLOGY OF AGING
- Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology
- (2007) Lijun Wang et al. NEUROBIOLOGY OF DISEASE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search