Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

(2016) Akira Kuzuya et al.   BMC BIOLOGY

Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

(2016) Akio Fukumori et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

(2016) Matthew G. Bursavich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

(2016) Chantell S. Evans et al.   MOLECULAR BIOLOGY OF THE CELL

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

(2016) Arun Kumar Somavarapu et al.   NEUROBIOLOGY OF DISEASE

Network synchronization in hippocampal neurons

(2016) Yaron Penn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal binning of time-correlated single photon counting data improves exponential decay fits and imaging speed

(2016) Alex J. Walsh et al.   Biomedical Optics Express

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

(2016) Sophia Schedin-Weiss et al.   Acta Neuropathologica Communications

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

(2015) Maria Szaruga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synaptotagmins interact with APP and promote Aβ generation

(2015) Vivek Gautam et al.   Molecular Neurodegeneration

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons

(2015) Masafumi Shimojo et al.   Cell Reports

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

(2015) Tomas Fanutza et al.   eLife

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction: PfRH5: A Novel Reticulocyte-Binding Family Homolog of Plasmodium falciparum that Binds to the Erythrocyte, and an Investigation of Its Receptor

(2014) Marilis Rodriguez et al.   PLoS One

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Activity-dependent secretion of progranulin from synapses

(2013) E. Petoukhov et al.   JOURNAL OF CELL SCIENCE

Decreased rabphilin 3A immunoreactivity in Alzheimer’s disease is associated with Aβ burden

(2013) Michelle G.K. Tan et al.   NEUROCHEMISTRY INTERNATIONAL

Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo

(2013) Victoria Heimer-McGinn et al.   NEUROSCIENCE LETTERS

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

(2013) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

(2013) Masayasu Okochi et al.   Cell Reports

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease

(2012) Lara Wahlster et al.   ACTA NEUROPATHOLOGICA

Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer’s disease

(2012) Antonio M.G. de Diego et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

(2012) Xuejing Li et al.   NEUROBIOLOGY OF DISEASE

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

(2011) Yu Ohki et al.   EMBO JOURNAL

A Novel Role for  -Secretase: Selective Regulation of Spontaneous Neurotransmitter Release from Hippocampal Neurons

(2011) K. G. Pratt et al.   JOURNAL OF NEUROSCIENCE

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

(2011) Kengo Uemura et al.   Molecular Neurodegeneration

Fluorescence Lifetime Measurements and Biological Imaging

(2010) Mikhail Y. Berezin et al.   CHEMICAL REVIEWS

Optical reporters of synaptic activity in neural circuits

(2010) Elena Dreosti et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Thin, Stubby or Mushroom: Spine Pathology in Alzheimers Disease

(2009) C. Tackenberg et al.   Current Alzheimer Research

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

(2008) Damien J. Keating et al.   HUMAN MOLECULAR GENETICS

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

(2007) Volodymyr Rybalchenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY