Synaptotagmins interact with APP and promote Aβ generation

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

BACE1 activity regulates cell surface contactin-2 levels

(2014) Vivek Gautam et al.   Molecular Neurodegeneration

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

(2014) Virginie Buggia-Prévot et al.   Cell Reports

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Amyloid Precursor Proteins Interact with the Heterotrimeric G Protein Go in the Control of Neuronal Migration

(2013) J. M. Ramaker et al.   JOURNAL OF NEUROSCIENCE

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D

(2013) Vivek Gautam et al.   NEUROPHARMACOLOGY

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen

(2012) Camin Dean et al.   MOLECULAR BIOLOGY OF THE CELL

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

(2011) Xiangdong Zhou et al.   FASEB JOURNAL

Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles

(2011) Jun Yao et al.   NATURE NEUROSCIENCE

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

Identification of NEEP21 as a  -Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro

(2010) E. M. Norstrom et al.   JOURNAL OF NEUROSCIENCE

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease

(2010) Victoria M. Perreau et al.   PROTEOMICS

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system

(2008) M. Osterfield et al.   DEVELOPMENT

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain

(2008) Tobias Mittelsteadt et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

(2008) Quan-Hong Ma et al.   NATURE CELL BIOLOGY

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Overexpression of APP stimulates basal and constitutive exocytosis in PC12 cells

(2008) Hye-Won Lee et al.   NEUROSCIENCE LETTERS