Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

Synaptotagmins interact with APP and promote Aβ generation

(2015) Vivek Gautam et al.   Molecular Neurodegeneration

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

(2015) Utpal Das et al.   NATURE NEUROSCIENCE

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

(2013) Iftach Dolev et al.   NATURE NEUROSCIENCE

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease

(2012) Lara Wahlster et al.   ACTA NEUROPATHOLOGICA

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

(2012) Xuejing Li et al.   NEUROBIOLOGY OF DISEASE

Effects of Brain Amyloid Deposition and Reduced Glucose Metabolism on the Default Mode of Brain Function in Normal Aging

(2011) M. Kikuchi et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Control of Neurotransmitter Release

(2011) T. C. Sudhof   Cold Spring Harbor Perspectives in Biology

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of  -Secretase-Mediated Intramembrane Proteolysis

(2010) A. Fukumori et al.   JOURNAL OF NEUROSCIENCE

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

(2009) Jun Xu et al.   NATURE NEUROSCIENCE

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Amyloid flirting with synaptic failure: Towards a comprehensive view of Alzheimer's disease pathogenesis

(2008) Elena Marcello et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON