Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

Calcium Binding Promotes Conformational Flexibility of the Neuronal Ca 2+ Sensor Synaptotagmin

(2015) Maria Bykhovskaia   BIOPHYSICAL JOURNAL

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering

(2015) Xiaochu Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening

(2015) Ying Lai et al.   Scientific Reports

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

(2014) Huisheng Liu et al.   NATURE NEUROSCIENCE

Prevalent mechanism of membrane bridging by synaptotagmin-1

(2013) Alpay B. Seven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for Calcium Ion Sensing by the C2A Domain of Synaptotagmin I

(2012) Jacob W. Gauer et al.   BIOPHYSICAL JOURNAL

Negative Coupling as a Mechanism for Signal Propagation between C2 Domains of Synaptotagmin I

(2012) Michael E. Fealey et al.   PLoS One

Mechanism and function of synaptotagmin-mediated membrane apposition

(2011) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane Repair

(2011) Angela Lek et al.   TRAFFIC

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

(2010) Colin P. Johnson et al.   JOURNAL OF CELL BIOLOGY

Regulation of Exocytosis and Fusion Pores by Synaptotagmin-Effector Interactions

(2010) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion

(2010) Marija Vrljic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Synaptotagmin C2B Domain Regulates Ca2+-triggered Fusionin Vitro

(2008) Jon D. Gaffaney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY