Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

Statistical Mechanics of the Denatured State of a Protein Using Replica-Averaged Metadynamics

(2014) Carlo Camilloni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Re-examining how complexin inhibits neurotransmitter release

(2014) Thorsten Trimbuch et al.   eLife

Analysis of SNARE Complex/Synaptotagmin-1 Interactions by One-Dimensional NMR Spectroscopy

(2013) Amy Zhou et al.   BIOCHEMISTRY

How reliable are pseudocontact shifts induced in proteins and ligands by mobile paramagnetic metal tags? A modelling study

(2013) Dmitry Shishmarev et al.   JOURNAL OF BIOMOLECULAR NMR

Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex

(2013) Junjie Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic Analysis of Synaptotagmin C2 Domain Specificity in Regulating Spontaneous and Evoked Neurotransmitter Release

(2013) J. Lee et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release

(2013) Taulant Bacaj et al.   NEURON

Prevalent mechanism of membrane bridging by synaptotagmin-1

(2013) Alpay B. Seven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release

(2012) Jörg Malsam et al.   EMBO JOURNAL

Characterization of the Conformational Equilibrium between the Two Major Substates of RNase A Using NMR Chemical Shifts

(2012) Carlo Camilloni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

DOTA-Amide Lanthanide Tag for Reliable Generation of Pseudocontact Shifts in Protein NMR Spectra

(2011) Bim Graham et al.   BIOCONJUGATE CHEMISTRY

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

(2011) Manu Sharma et al.   EMBO JOURNAL

Protein–protein HADDocking using exclusively pseudocontact shifts

(2011) Christophe Schmitz et al.   JOURNAL OF BIOMOLECULAR NMR

Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings

(2011) Alfonso De Simone et al.   Journal of Chemical Theory and Computation

Binding of Low Molecular Weight Inhibitors Promotes Large Conformational Changes in the Dengue Virus NS2B-NS3 Protease: Fold Analysis by Pseudocontact Shifts

(2011) Laura de la Cruz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein NMR Using Paramagnetic Ions

(2010) Gottfried Otting   Annual Review of Biophysics

Synaptotagmin 1 and SNAREs Form a Complex That Is Structurally Heterogeneous

(2010) Alex L. Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Calmodulin Controls Synaptic Strength via Presynaptic Activation of Calmodulin Kinase II

(2010) Z. P. Pang et al.   JOURNAL OF NEUROSCIENCE

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-Molecule Studies of the Neuronal SNARE Fusion Machinery

(2009) Axel T. Brunger et al.   Annual Review of Biochemistry

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl groups as probes of supra-molecular structure, dynamics and function

(2009) Amy M. Ruschak et al.   JOURNAL OF BIOMOLECULAR NMR

Avoiding Nonspecific Interactions in Studies of the Plasma Proteome: Practical Solutions to Prevention of Nonspecific Interactions for Label-Free Detection of Low-Abundance Plasma Proteins

(2009) Joanna L. Richens et al.   JOURNAL OF PROTEOME RESEARCH

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

(2009) Jun Xu et al.   NATURE NEUROSCIENCE

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

(2009) O.-H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

Observing biological dynamics at atomic resolution using NMR

(2009) Anthony K. Mittermaier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Numbat: an interactive software tool for fitting Δχ-tensors to molecular coordinates using pseudocontact shifts

(2008) Christophe Schmitz et al.   JOURNAL OF BIOMOLECULAR NMR

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

(2008) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY