The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 GeneHighlights

(2016) Alejandra Rodríguez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Non-alcoholic fatty liver disease and risk of type 2 diabetes

(2016) S. Lallukka et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

(2016) Geoffrey A. Walford et al.   DIABETES

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

(2016) Aldons J. Lusis et al.   JOURNAL OF LIPID RESEARCH

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

(2016) Robert A. Scott et al.   Science Translational Medicine

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

(2016) Yingchang Lu et al.   Nature Communications

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

(2015) Tamara S. Roman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men

(2015) Maria Fizelova et al.   ATHEROSCLEROSIS

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant atCCND2Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

(2015) Hanieh Yaghootkar et al.   DIABETES

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

(2015) Maria A. Lankinen et al.   DIABETOLOGIA

Recent advances in understanding the genetic architecture of type 2 diabetes

(2015) Karen L. Mohlke et al.   HUMAN MOLECULAR GENETICS

Directional dominance on stature and cognition in diverse human populations

(2015) Peter K. Joshi et al.   NATURE

Deep phenotyping: The details of disease

(2015) Cathryn M. Delude   NATURE

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

(2015) Jennifer Wessel et al.   Nature Communications

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

(2015) Anubha Mahajan et al.   PLoS Genetics

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men

(2015) Jagadish Vangipurapu et al.   PLoS One

A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

(2014) Jennifer R. Kulzer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Insulin resistance and hyperglycaemia in cardiovascular disease development

(2014) Markku Laakso et al.   Nature Reviews Endocrinology

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

(2014) Elaine T. Lim et al.   PLoS Genetics

A Central Role for GRB10 in Regulation of Islet Function in Man

(2014) Inga Prokopenko et al.   PLoS Genetics

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes

(2013) Yuvaraj Mahendran et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men

(2013) Y. Mahendran et al.   DIABETES

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

(2013) H. Yaghootkar et al.   DIABETES

Glycerol and Fatty Acids in Serum Predict the Development of Hyperglycemia and Type 2 Diabetes in Finnish Men

(2013) Y. Mahendran et al.   DIABETES CARE

Desmosterol in human nonalcoholic steatohepatitis

(2013) Marko Simonen et al.   HEPATOLOGY

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

(2013) Mete Civelek et al.   HUMAN MOLECULAR GENETICS

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish Men

(2013) Henna Cederberg et al.   PLoS One

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

(2013) Ying Wu et al.   PLoS Genetics

Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

(2012) Kati Kristiansson et al.   Circulation-Cardiovascular Genetics

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

(2012) Robert A. Scott et al.   DIABETES

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

(2012) A. Stancakova et al.   DIABETES

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

(2012) Jeroen R Huyghe et al.   NATURE GENETICS

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

(2012) Aparna Pal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

(2012) Zari Dastani et al.   PLoS Genetics

Evidence of How rs7575840 Influences Apolipoprotein B–Containing Lipid Particles

(2011) Blake E. Haas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

(2011) Thomas Koeck et al.   Cell Metabolism

Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men

(2011) A. Stancakova et al.   DIABETES

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

(2011) Ervin R. Fox et al.   HUMAN MOLECULAR GENETICS

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

(2011) Jussi Pihlajamäki et al.   JOURNAL OF HEPATOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

(2011) Tuomas O Kilpeläinen et al.   NATURE GENETICS

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Mass spectrometry–based proteomics in cell biology

(2010) Tobias C. Walther et al.   JOURNAL OF CELL BIOLOGY

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface

(2009) Sami Heikkinen et al.   Cell Metabolism

Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose

(2009) Xia Li et al.   DIABETES

Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

(2009) A. Stancakova et al.   DIABETES

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

(2009) A. Stancakova et al.   DIABETES

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS