Mendelian randomization: genetic anchors for causal inference in epidemiological studies

Methodological Challenges in Mendelian Randomization

(2014) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

(2014) Rebecca C. Richmond et al.   PLOS MEDICINE

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

(2013) David R. Blair et al.   CELL

Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study

(2013) Stefan Stender et al.   HEPATOLOGY

What Are the Key Arguments Against Uric Acid as a True Risk Factor for Hypertension?

(2013) Richard J. Johnson et al.   HYPERTENSION

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Prenatal alcohol exposure and offspring cognition and school performance. A ‘Mendelian randomization’ natural experiment

(2013) Luisa Zuccolo et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Use of allele scores as instrumental variables for Mendelian randomization

(2013) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Misclassification of the mediator matters when estimating indirect effects

(2013) Tony Blakely et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

From promises to practical strategies in epigenetic epidemiology

(2013) Jonathan Mill et al.   NATURE REVIEWS GENETICS

Causal inference of gene regulation with subnetwork assembly from genetical genomics data

(2013) Chien-Hua Peng et al.   NUCLEIC ACIDS RESEARCH

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

(2013) T. M. Palmer et al.   BMJ-British Medical Journal

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

(2013) David M. Evans et al.   PLoS Genetics

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

(2013) Irene Pichler et al.   PLOS MEDICINE

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

Negative Control Exposures in Epidemiologic Studies

(2012) Marc Lipsitch et al.   EPIDEMIOLOGY

Quantification of Bias in Direct Effects Estimates Due to Different Types of Measurement Error in the Mediator

(2012) Saskia le Cessie et al.   EPIDEMIOLOGY

The Role of Measurement Error and Misclassification in Mediation Analysis

(2012) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Commentary: The seven plagues of epigenetic epidemiology

(2012) Bastiaan T Heijmans et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

(2012)   LANCET

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

(2012) Tanica Lyngdoh et al.   PLoS One

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

(2012) J. H. Bjørngaard et al.   PSYCHOLOGICAL MEDICINE

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

(2012) Børge G. Nordestgaard et al.   PLOS MEDICINE

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Mendelian Randomization: Application to Cardiovascular Disease

(2011) Nicholas J. Timpson et al.   CURRENT HYPERTENSION REPORTS

Random Allocation in Observational Data

(2011) George Davey Smith   EPIDEMIOLOGY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

(2011) J. A. Hubacek et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Smoking Is Associated with, but Does Not Cause, Depressed Mood in Pregnancy – A Mendelian Randomization Study

(2011) Sarah J. Lewis et al.   PLoS One

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes

(2010) Elias Chaibub Neto et al.   Annals of Applied Statistics

Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

(2010) George Davey Smith   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

(2010) George Davey Smith   Genes and Nutrition

One Hundred Years of Pleiotropy: A Retrospective

(2010) F. W. Stearns   GENETICS

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

Mendelian randomization analysis of case-control data using structural mean models

(2010) Jack Bowden et al.   STATISTICS IN MEDICINE

Usefulness of Mendelian Randomization in Observational Epidemiology

(2010) Murielle Bochud et al.   International Journal of Environmental Research and Public Health

Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?

(2009) Nicholas J. Timpson et al.   HYPERTENSION

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

(2008) R. M. Freathy et al.   DIABETES

How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach

(2008) Nicholas J Timpson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pleiotropic scaling of gene effects and the ‘cost of complexity’

(2008) Günter P. Wagner et al.   NATURE

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

(2008) Debbie A Lawlor et al.   PLOS MEDICINE

Mendelian Randomisation and Causal Inference in Observational Epidemiology

(2008) Nuala A Sheehan et al.   PLOS MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE